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View article: Molecular Logic of Cell Diversity and Circuit Connectivity in the REM Sleep Hub
Molecular Logic of Cell Diversity and Circuit Connectivity in the REM Sleep Hub Open
The complexity of the brain arises from the diversity of its circuits and the molecular heterogeneity of the cells that compose them. A mechanistic understanding therefore requires mapping cellular identity and connectivity at single-cell …
View article: GABA neurons in the sublaterodorsal tegmental (SLD) nucleus suppress wakefulness in wild-type and narcoleptic mice
GABA neurons in the sublaterodorsal tegmental (SLD) nucleus suppress wakefulness in wild-type and narcoleptic mice Open
The sleep-wake cycle is generated by competing neural circuits that control the oscillation between wakefulness, rapid eye movement (REM) sleep, and non-REM (NREM) sleep. While the sublaterodorsal tegmental nucleus (SLD) is recognized for …
View article: Identification of multiple hypoxia‐independent triggers of upper airway long‐term facilitation in a rat model of upper airway motor plasticity
Identification of multiple hypoxia‐independent triggers of upper airway long‐term facilitation in a rat model of upper airway motor plasticity Open
The respiratory control system can exhibit neuronal plasticity following exposures to repetitive respiratory challenges. For example, repeated obstructive apneas can trigger a form of respiratory plasticity that results in the enhancement …
View article: Multiple Hypoxia-Independent Triggers of Upper Airway Long-Term Facilitation
Multiple Hypoxia-Independent Triggers of Upper Airway Long-Term Facilitation Open
The respiratory control system can augment respiratory output following repetitive challenges. For example, repeated airway obstructions can trigger a form of respiratory memory that strengthens inspiratory activity of hypoglossal (XII) mo…
View article: A novel machine learning system for identifying sleep–wake states in mice
A novel machine learning system for identifying sleep–wake states in mice Open
Research into sleep–wake behaviors relies on scoring sleep states, normally done by manual inspection of electroencephalogram (EEG) and electromyogram (EMG) recordings. This is a highly time-consuming process prone to inter-rater variabili…
View article: Dopamine neurons in the ventral tegmental area modulate rapid eye movement sleep
Dopamine neurons in the ventral tegmental area modulate rapid eye movement sleep Open
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View article: Glutamate neurons in the pedunculopontine tegmental nucleus control arousal state and motor behavior in mice
Glutamate neurons in the pedunculopontine tegmental nucleus control arousal state and motor behavior in mice Open
Journal Article Glutamate neurons in the pedunculopontine tegmental nucleus control arousal state and motor behavior in mice Get access Brittany J Dugan, Brittany J Dugan Department of Cell and Systems Biology, University of Toronto Corres…
View article: 006 The effect of sodium oxybate on cataplexy in orexin knockout mice
006 The effect of sodium oxybate on cataplexy in orexin knockout mice Open
Introduction Narcolepsy is a neurological disorder that is characterized by the loss of orexin neurons in the lateral hypothalamus. Cataplexy is a symptom of narcolepsy and is identified by a sudden loss of muscle tone during wakefulness. …
View article: Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy
Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy Open
Excessive daytime sleepiness (EDS) and cataplexy are common symptoms of narcolepsy, a sleep disorder associated with the loss of hypocretin/orexin (Hcrt) neurons. Although only a few drugs have received regulatory approval for narcolepsy t…
View article: 0144 ACTIVATION OF GLUTAMATE CELLS IN THE SUBCOERLEUS NUCLEUS TRIGGERS CATAPLEXY-LIKE ATTACKS IN WILD-TYPE MICE
0144 ACTIVATION OF GLUTAMATE CELLS IN THE SUBCOERLEUS NUCLEUS TRIGGERS CATAPLEXY-LIKE ATTACKS IN WILD-TYPE MICE Open
Cataplexy is characterized by the sudden uncontrollable loss in skeletal muscle tone during wakefulness and is hypothesized to be triggered by the same brainstem circuits that generate REM sleep. Recently, we determined that glutamate neur…
View article: New neuroscience tools that are identifying the sleep-wake circuit
New neuroscience tools that are identifying the sleep-wake circuit Open
The complexity of the brain is yielding to technology. In the area of sleep neurobiology, conventional neuroscience tools such as lesions, cell recordings, c-Fos, and axon-tracing methodologies have been instrumental in identifying the com…
View article: GABA Cells in the Central Nucleus of the Amygdala Promote Cataplexy
GABA Cells in the Central Nucleus of the Amygdala Promote Cataplexy Open
Cataplexy is a hallmark of narcolepsy characterized by the sudden uncontrollable onset of muscle weakness or paralysis during wakefulness. It can occur spontaneously, but is typically triggered by positive emotions such as laughter. Althou…
View article: Monoamine Release during Unihemispheric Sleep and Unihemispheric Waking in the Fur Seal
Monoamine Release during Unihemispheric Sleep and Unihemispheric Waking in the Fur Seal Open
Study objectivesOur understanding of the role of neurotransmitters in the control of the electroencephalogram (EEG) has been entirely based on studies of animals with bilateral sleep. The study of animals with unihemispheric sleep presents…
View article: REM Sleep at its Core – Circuits, Neurotransmitters, and Pathophysiology
REM Sleep at its Core – Circuits, Neurotransmitters, and Pathophysiology Open
Rapid eye movement (REM) sleep is generated and maintained by the interaction of a variety of neurotransmitter systems in the brainstem, forebrain, and hypothalamus. Within these circuits lies a core region that is active during REM sleep,…