John Pepper
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View article: Five-year results from a prospective, single-arm European trial on decellularized allografts for aortic valve replacement—the ARISE Study and ARISE Registry Data
Five-year results from a prospective, single-arm European trial on decellularized allografts for aortic valve replacement—the ARISE Study and ARISE Registry Data Open
OBJECTIVES Decellularized aortic homografts (DAH) were introduced as a new option for aortic valve replacement for young patients. METHODS A prospective, EU-funded, single-arm, multicentre study in 8 centres evaluating non-cryopreserved DA…
View article: Consensus statement—graft treatment in cardiovascular bypass graft surgery
Consensus statement—graft treatment in cardiovascular bypass graft surgery Open
Coronary artery bypass grafting (CABG) is and continues to be the preferred revascularization strategy in patients with multivessel disease. Graft selection has been shown to influence the outcomes following CABG. During the last almost 60…
View article: Durable Continuous-Flow Mechanical Circulatory Support
Durable Continuous-Flow Mechanical Circulatory Support Open
The prevalence of heart failure in the UK is 1 in 35 people aged from 65 to 74 and 1 in 15 people aged from 75 to 84 [...]
View article: Formal consensus study on surgery to replace the aortic valve in adults aged 18–60 years
Formal consensus study on surgery to replace the aortic valve in adults aged 18–60 years Open
Objective There is uncertainty about surgical procedures for adult patients aged 18–60 years undergoing aortic valve replacement (AVR). Options include conventional AVR (mechanical, mAVR; tissue, tAVR), the pulmonary autograft (Ross) and a…
View article: Matched comparison between external aortic root support and valve-sparing root replacement
Matched comparison between external aortic root support and valve-sparing root replacement Open
Objectives Differences in indication and technique make a randomised comparison between valve-sparing root replacement (VSRR) and personalised external aortic root support (PEARS) challenging. We performed a propensity score (PS)-matched c…
View article: Fluid-Structure Interaction Simulations of Repaired Type A Aortic Dissection: a Comprehensive Comparison With Rigid Wall Models
Fluid-Structure Interaction Simulations of Repaired Type A Aortic Dissection: a Comprehensive Comparison With Rigid Wall Models Open
This study aimed to evaluate the effect of aortic wall compliance on intraluminal hemodynamics within surgically repaired type A aortic dissection (TAAD). Fully coupled two-way fluid-structure interaction (FSI) simulations were performed o…
View article: The impact of COVID-19 pandemic on aortic valve surgical service: a single centre experience
The impact of COVID-19 pandemic on aortic valve surgical service: a single centre experience Open
Background The coronavirus-disease 2019 (COVID-19) pandemic imposed an unprecedented burden on the provision of cardiac surgical services. The reallocation of workforce and resources necessitated the postponement of elective operations in …
View article: Personalised external aortic root support for elective treatment of aortic root dilation in 200 patients
Personalised external aortic root support for elective treatment of aortic root dilation in 200 patients Open
Background and objectives In personalised external aortic root support (PEARS), a custom-made, macroporous mesh is used to stabilise a dilated aortic root and prevent dissection, primarily in patients with genetically driven aortopathies. …
View article: Molecular characterization of the highest risk adult patients with acute myeloid leukemia (AML) through multi-omics clustering
Molecular characterization of the highest risk adult patients with acute myeloid leukemia (AML) through multi-omics clustering Open
Background: Acute myeloid leukemia (AML) is a clinically heterogeneous group of diseases with poor outcomes that are partly due to its complex and poorly understood heterogeneity. Methods: Here, we use a multi-omics approach to identify a …
View article: The impact of COVID-19 pandemic on aortic valve surgical service: a single centre experience.
The impact of COVID-19 pandemic on aortic valve surgical service: a single centre experience. Open
Background The coronavirus-disease 2019 (COVID-19) pandemic imposed an unprecedented burden on the provision of cardiac surgical services. The reallocation of workforce and resources necessitated the postponement of elective operations in …
View article: Personalized external aortic root support
Personalized external aortic root support Open
OBJECTIVES Implantation of a personalized external aortic root support (PEARS) can prevent dilatation of the aortic root and ascending aorta in patients with aortopathy of various aetiologies. Because PEARS is an emerging technology, all a…
View article: Personalised external aortic root support (PEARS) to stabilise an aortic root aneurysm
Personalised external aortic root support (PEARS) to stabilise an aortic root aneurysm Open
Patients with congenitally determined aortic root aneurysms are at risk of aortic valve regurgitation, aortic dissection, rupture and death. Personalised external aortic root support (PEARS) may provide an alternative to aortic root replac…
View article: Phase-contrast magnetic resonance imaging and computational fluid dynamics assessment of thoracic aorta blood flow: a literature review
Phase-contrast magnetic resonance imaging and computational fluid dynamics assessment of thoracic aorta blood flow: a literature review Open
The death rate from thoracic aortic disease is on the rise and represents a growing global health concern as patients are often asymptomatic before acute events, which have devastating effects on health-related quality of life. Biomechanic…
View article: 75 The effects of atrial fibrillation on left ventricular mechanics and genomics in mitral regurgitation
75 The effects of atrial fibrillation on left ventricular mechanics and genomics in mitral regurgitation Open
Background The development of atrial fibrillation (AF) in mitral valve regurgitation (MR) adversely affects patient's long term outcome despite successful surgical repair. The fundamental changes in LV myocardial mechanics and genomics in …
View article: Aortic Root Surgery in Marfan Disease: Outcome After Contemporary Surgery, Personalised External Aortic Root Support and Microsimulation
Aortic Root Surgery in Marfan Disease: Outcome After Contemporary Surgery, Personalised External Aortic Root Support and Microsimulation Open
Objective: Total aortic root (TRR) and valve-sparing aortic root (VSRR) replacement surgery has improved life expectancy in Marfan disease patients (MFS). Determining the difference in outcomes after surgery is challenging due to small pop…
View article: Sutureless Aortic Valve Replacement (AVR) for Prosthetic Valve Endocarditis: A Single Centre Experience
Sutureless Aortic Valve Replacement (AVR) for Prosthetic Valve Endocarditis: A Single Centre Experience Open
Objective: Prosthetic aortic valve endocarditis carries significant morbidity and mortality. The use of sutureless valves in this setting is regarded as a contra-indication and this series describes our experience and short term outcomes i…
View article: Porcine Aortic Root Replacement in Acute Aortic Dissection
Porcine Aortic Root Replacement in Acute Aortic Dissection Open
Objective: Aortic root replacement (ARR) may be necessary during repair of Type A Acute Aortic Dissection (AAD). We compared the early & midterm outcomes of patients undergoing Porcine ARR with those undergoing mechanical Bentall procedure…
View article: Assessment of Stroke Volume Index of Sutureless, Transcatheter and Stented Pericardial Valves in the Early Postoperative Period - a Propensity Matched Analysis
Assessment of Stroke Volume Index of Sutureless, Transcatheter and Stented Pericardial Valves in the Early Postoperative Period - a Propensity Matched Analysis Open
Objective: Persistent or new onset low flow (LF), described as a stroke volume index (SVi) less than 35ml/m2/beat, is a predictor of poor outcomes after aortic valve intervention (AVI) in patients (pts) with severe aortic stenosis (AS) and…
View article: Aortic Valve Function at Medium-term Follow-up after Resuspension During Repair of Acute Type A Aortic Dissection. Royal Brompton and Harefield Hospitals, Experience
Aortic Valve Function at Medium-term Follow-up after Resuspension During Repair of Acute Type A Aortic Dissection. Royal Brompton and Harefield Hospitals, Experience Open
Objective: Aortic Valve Resuspension (AVS) at the time of dissection repair is a technique with excellent early outcomes in terms of aortic valve (AV) function. However, limited data is available with regard to medium-term durability of th…
View article: Impact of a streamlined rotational system for the management of acute aortic syndrome: sharing is caring†
Impact of a streamlined rotational system for the management of acute aortic syndrome: sharing is caring† Open
A streamlined aortic dissection service allows for centralized care. This provides the referring centres with 24/7 access to an experienced aortic team and may improve patient outcomes.