John Pierce Wise
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View article: Hexavalent Chromium Oropharyngeal Aspiration Induced Behavior Effects and Essential Metal Dyshomeostasis in Young Hartley Guinea Pigs
Hexavalent Chromium Oropharyngeal Aspiration Induced Behavior Effects and Essential Metal Dyshomeostasis in Young Hartley Guinea Pigs Open
Hexavalent chromium [Cr(VI)] is the toxic form of chromium often used in industry for its hardness, bright colors, and anticorrosive properties. Cr(VI) is a known human lung carcinogen, making its inhalation an occupational hazard. Growing…
View article: Genome-Wide Demographic Analyses of Balaenid Whales Revealed Complex History of Gene Flow Associated with Past Climate Oscillation
Genome-Wide Demographic Analyses of Balaenid Whales Revealed Complex History of Gene Flow Associated with Past Climate Oscillation Open
The balaenid whale, comprising three species of right whales and the bowhead whale, represents an ancient and highly endangered lineage of marine mammals. To unravel the evolutionary history of balaenid whales with respect to gene flow, a …
View article: Change in matrilineal structure over time in an isolated population of sperm whales
Change in matrilineal structure over time in an isolated population of sperm whales Open
Sperm whales Physeter macrocephalus resident in the Gulf of Mexico are geographically isolated from other populations, making them vulnerable to the impacts of oil and gas exploration prevalent in the region. Despite long-standing research…
View article: Acute particulate hexavalent chromium exposure induces DNA double-strand breaks and activates homologous recombination repair in rat lung tissue
Acute particulate hexavalent chromium exposure induces DNA double-strand breaks and activates homologous recombination repair in rat lung tissue Open
Hexavalent chromium [Cr(VI)] is an established human lung carcinogen, but the carcinogenesis mechanism is poorly understood. Chromosome instability, a hallmark of lung cancer, is considered a major driver of Cr(VI)-induced lung cancer. Unr…
View article: A whale of a tale: whale cells evade the driving mechanism for hexavalent chromium-induced chromosome instability
A whale of a tale: whale cells evade the driving mechanism for hexavalent chromium-induced chromosome instability Open
Chromosome instability, a hallmark of lung cancer, is a driving mechanism for hexavalent chromium [Cr(VI)] carcinogenesis in humans. Cr(VI) induces structural and numerical chromosome instability in human lung cells by inducing DNA double-…
View article: Genome-wide demographic analyses of balaenid whales revealed complex history of gene flow associated with past climate oscillation
Genome-wide demographic analyses of balaenid whales revealed complex history of gene flow associated with past climate oscillation Open
The balaenid whale, comprising three species of right whales and the bowhead whale, represents an ancient and highly endangered lineage of marine mammals. To unravel the evolutionary history of balaenid whales with respect to gene flow, a …
View article: Hexavalent Chromium Targets Securin to Drive Numerical Chromosome Instability in Human Lung Cells
Hexavalent Chromium Targets Securin to Drive Numerical Chromosome Instability in Human Lung Cells Open
Hexavalent chromium [Cr(VI)] is a known human lung carcinogen with widespread exposure in environmental and occupational settings. Despite well-known cancer risks, the molecular mechanisms of Cr(VI)-induced carcinogenesis are not well unde…
View article: Among Gerontogens, Heavy Metals Are a Class of Their Own: A Review of the Evidence for Cellular Senescence
Among Gerontogens, Heavy Metals Are a Class of Their Own: A Review of the Evidence for Cellular Senescence Open
Advancements in modern medicine have improved the quality of life across the globe and increased the average lifespan of our population by multiple decades. Current estimates predict by 2030, 12% of the global population will reach a geria…
View article: Editorial: Healthspan and neural aging: Merging the exposome and one environmental health - From molecular mechanisms to epidemiology
Editorial: Healthspan and neural aging: Merging the exposome and one environmental health - From molecular mechanisms to epidemiology Open
EDITORIAL article Front. Aging Neurosci., 14 March 2023Sec. Cellular and Molecular Mechanisms of Brain-aging Volume 15 - 2023 | https://doi.org/10.3389/fnagi.2023.1172967
View article: The intersection between toxicology and aging research: A toxic aging coin perspective
The intersection between toxicology and aging research: A toxic aging coin perspective Open
We are imminently faced with the challenges of an increasingly aging population and longer lifespans due to improved health care. Concomitantly, we are faced with ubiquitous environmental pollution linked with various health effects and ag…
View article: A Case Study for Teaching Toxicology: Using Whales as an Indicator for Environmental Health
A Case Study for Teaching Toxicology: Using Whales as an Indicator for Environmental Health Open
One of the challenges of teaching scientific courses is helping students understand research methods, biological models, and data analysis, which can be especially difficult in classes without a laboratory component. Within the field of to…
View article: Current understanding of hexavalent chromium [Cr(VI)] neurotoxicity and new perspectives
Current understanding of hexavalent chromium [Cr(VI)] neurotoxicity and new perspectives Open
Hexavalent chromium [Cr(VI)] is a global environmental pollutant that increases risk for several types of cancers and is increasingly being recognized as a neurotoxicant. Traditionally, the brain has been viewed as a largely post-mitotic o…
View article: Particulate Hexavalent Chromium Inhibits E2F1 Leading to Reduced RAD51 Nuclear Foci Formation in Human Lung Cells
Particulate Hexavalent Chromium Inhibits E2F1 Leading to Reduced RAD51 Nuclear Foci Formation in Human Lung Cells Open
Lung cancer is the leading cause of cancer death; however, the mechanisms of lung carcinogens are poorly understood. Metals, including hexavalent chromium [Cr(VI)], induce chromosome instability, an early event in lung cancer. Failure of h…
View article: Microplastics in Sea Turtles, Marine Mammals and Humans: A One Environmental Health Perspective
Microplastics in Sea Turtles, Marine Mammals and Humans: A One Environmental Health Perspective Open
Microplastics are ubiquitous pollutants in the marine environment and a health concern. They are generated directly for commercial purposes or indirectly from the breakdown of larger plastics. Examining a toxicological profile for micropla…
View article: Polycyclic Aromatic Hydrocarbon-DNA Adducts in Gulf of Mexico Sperm Whale Skin Biopsies Collected in 2012
Polycyclic Aromatic Hydrocarbon-DNA Adducts in Gulf of Mexico Sperm Whale Skin Biopsies Collected in 2012 Open
The northern Gulf of Mexico has a long history of polycyclic aromatic hydrocarbon (PAH) contamination from anthropogenic activities, natural oil seepages, and the 2010 Deepwater Horizon explosion and oil spill. The continental shelf of the…
View article: Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead Open
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of c…
View article: Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands
Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands Open
Cells continually degrade and replace damaged and old proteins. However, the high energetic demand of protein turnover generates reactive oxygen species (ROS) that compromise the long-term health of the proteome. Thus, the relationship bet…