John Poh
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View article: Infants of hepatitis B surface antigen-positive women of Black ethnicity in the UK may be at risk of acquiring human T-cell lymphotropic virus type 1
Infants of hepatitis B surface antigen-positive women of Black ethnicity in the UK may be at risk of acquiring human T-cell lymphotropic virus type 1 Open
Avoidable HTLV-1 vertical transmissions are likely occurring in this population, calling for strengthened public health interventions.
View article: Comprehensive CMR to differentiate between fitness levels amongst veteran endurance athletes
Comprehensive CMR to differentiate between fitness levels amongst veteran endurance athletes Open
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): British Heart Foundation. Background Myocardial fibrosis has been demonstrated to be highly prevalent amongst endurance athletes. However, it …
View article: CHANGES IN SARS-COV-2 ANTIBODY PREVALENCE IN PRIMARY AND SECONDARY SCHOOLS STUDENTS DURING THE EMERGENCE OF THE OMICRON VARIANT: THE UK SCHOOLS INFECTION SURVEYS
CHANGES IN SARS-COV-2 ANTIBODY PREVALENCE IN PRIMARY AND SECONDARY SCHOOLS STUDENTS DURING THE EMERGENCE OF THE OMICRON VARIANT: THE UK SCHOOLS INFECTION SURVEYS Open
INTRO: Children and Young people were the last group in England be offered COVID-19 vaccination (from September 2021), thus were the largest susceptible group when SARS-CoV-2 Omicron variants emerged. We monitored vaccine and naturally-der…
View article: Antibody Persistence After Primary SARS-CoV-2 Infection and Protection Against Future Variants Including Omicron in Adolescents: National, Prospective Cohort Study
Antibody Persistence After Primary SARS-CoV-2 Infection and Protection Against Future Variants Including Omicron in Adolescents: National, Prospective Cohort Study Open
Background: Antibodies are a measure of immunity after primary infection, which may help protect against further SARS-CoV-2 infections. They may also provide some cross-protection against SARS-CoV-2 variants. There are limited data on anti…
View article: Risk factors for SARS-CoV-2 infection in primary and secondary school students and staff in England in the 2020/2021 school year: a longitudinal study
Risk factors for SARS-CoV-2 infection in primary and secondary school students and staff in England in the 2020/2021 school year: a longitudinal study Open
Deprivation, community, and household factors were more strongly associated with infection than contacts patterns at school; this suggests that the additional school-based mitigation measures in England in 2020/2021 likely helped reduce tr…
View article: National and regional prevalence of SARS-CoV-2 antibodies in primary and secondary school children in England: the School Infection Survey, a national open cohort study, November 2021
National and regional prevalence of SARS-CoV-2 antibodies in primary and secondary school children in England: the School Infection Survey, a national open cohort study, November 2021 Open
Background Risk factors for infection and, therefore, antibody positivity rates will be different in children compared to adults. We aim to estimate national and regional prevalence of SARS-CoV-2 antibodies in primary (4-11-year-olds) and …
View article: mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273
mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273 Open
Children and adolescents generally experience mild COVID-19. However, those with underlying physical health conditions are at a significantly increased risk of severe disease. Here, we present a comprehensive analysis of antibody and cellu…
View article: The COVID-19 Schools Infection Survey in England: Protocol and Participation Profile for a Prospective Observational Cohort Study
The COVID-19 Schools Infection Survey in England: Protocol and Participation Profile for a Prospective Observational Cohort Study Open
Background One of the most debated questions in the COVID-19 pandemic has been the role of schools in SARS-CoV-2 transmission. The COVID-19 Schools Infection Survey (SIS) aims to provide much-needed evidence addressing this issue. Objectiv…
View article: Secondary attack rates in primary and secondary school bubbles following a confirmed case: Active, prospective national surveillance, November to December 2020, England
Secondary attack rates in primary and secondary school bubbles following a confirmed case: Active, prospective national surveillance, November to December 2020, England Open
Background Following the full re-opening of schools in England and emergence of the SARS-CoV-2 Alpha variant, we investigated the risk of SARS-CoV-2 infection in students and staff who were contacts of a confirmed case in a school bubble (…
View article: SARS Antibody Testing in Children: Development of Oral Fluid Assays for IgG Measurements
SARS Antibody Testing in Children: Development of Oral Fluid Assays for IgG Measurements Open
We report on the first large-scale assessment of the suitability of oral fluids for detection of SARS-CoV-2 antibody obtained from healthy children attending school. The sample type (gingiva-crevicular fluid, which is a transudate of blood…
View article: Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection Open
SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome is unclear. Here we compare antibody and cellular immunity in children (aged 3–11 years) and adults. Antibody responses against spik…
View article: Emergence of the Delta Variant and risk of SARS-CoV-2 infection in secondary school students and staff: prospective surveillance in 18 schools, England
Emergence of the Delta Variant and risk of SARS-CoV-2 infection in secondary school students and staff: prospective surveillance in 18 schools, England Open
Background The role of educational settings on SARS-CoV-2 infection and transmission remains controversial. We investigated SARS-CoV-2 infection, seroprevalence and seroconversions rates in secondary schools during the 2020/21 academic yea…
View article: The COVID-19 Schools Infection Survey in England: Protocol and participation profile for a prospective, observational cohort study (Preprint)
The COVID-19 Schools Infection Survey in England: Protocol and participation profile for a prospective, observational cohort study (Preprint) Open
BACKGROUND One of the most debated questions in the COVID-19 pandemic has been the role of schools in SARS-CoV-2 transmission. The COVID-19 Schools Infection Survey (SIS) aims to provide much-needed evidence addressing this. OBJECTIVE T…
View article: Emergence of SARS-CoV-2 Alpha (B.1.1.7) variant, infection rates, antibody seroconversion and seroprevalence rates in secondary school students and staff: active prospective surveillance, December 2020 to March 2021, England
Emergence of SARS-CoV-2 Alpha (B.1.1.7) variant, infection rates, antibody seroconversion and seroprevalence rates in secondary school students and staff: active prospective surveillance, December 2020 to March 2021, England Open
Background In England, the rapid spread of the SARS-Cov-2 Alpha (B.1.1.7) variant from November 2020 led to national lockdown, including school closures in January 2021. We assessed SARS-CoV-2 infection, seroprevalence and seroconversion i…
View article: Antibody persistence and neutralising activity in primary school students and staff: prospective active surveillance, June to December 2020, England
Antibody persistence and neutralising activity in primary school students and staff: prospective active surveillance, June to December 2020, England Open
Introduction SARS-CoV-2 serological studies have so far focused mainly on adults. Public Health England initiated prospective, longitudinal SARS-CoV-2 sero-surveillance in schools across England after the first national lockdown, which all…
View article: SARS-CoV-2 IgG detection in human oral fluids
SARS-CoV-2 IgG detection in human oral fluids Open
Seroepidemiological studies to monitor antibody kinetics are important for assessing the extent and spread of SARS-CoV-2 in a population. Non-invasive sampling methods are advantageous to reduce the need for venepuncture, which may be a ba…
View article: Children develop robust and sustained cross-reactive spike-specific immune responses following SARS-CoV-2 infection
Children develop robust and sustained cross-reactive spike-specific immune responses following SARS-CoV-2 infection Open
SARS-CoV-2 infection is generally mild or asymptomatic in children but the biological basis for this is unclear. We studied the profile of antibody and cellular immunity in children aged 3-11 years in comparison with adults. Antibody respo…