John R. Best
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View article: Brain Health PRO: Evaluating a Web‐Based Multidomain Intervention to Improve Dementia Literacy and Self‐Efficacy
Brain Health PRO: Evaluating a Web‐Based Multidomain Intervention to Improve Dementia Literacy and Self‐Efficacy Open
Background Early interventions addressing lifestyle‐related risk factors present a compelling strategy for mitigating cognitive decline. In response to this need, the Canadian Consortium on Neurodegeneration in Aging has developed Brain He…
View article: Walking to Protect Against Cognitive Decline: The Role of APOE Genotype, Sex, and Race
Walking to Protect Against Cognitive Decline: The Role of APOE Genotype, Sex, and Race Open
Background The apolipoprotein E (APOE) ε4 allele is a well‐established genetic risk factor for cognitive decline and late‐onset Alzheimer's disease with stronger effects in females, while the ε2 allele may offer protective effects. Physica…
View article: A web‐based multidomain intervention improves modifiable risk factors for Alzheimer's disease
A web‐based multidomain intervention improves modifiable risk factors for Alzheimer's disease Open
Background The Canadian Therapeutics Platform for Multidomain Interventions to Prevent Dementia (CAN‐THUMBS UP (CTU)) was developed to address modifiable lifestyle risk factors through its online program Brain Health PRO (BHPro), to enable…
View article: Comparing Traditional and Digital Cognitive Assessments in an Online Dementia Risk Reduction Program: Results from the CAN‐THUMBS‐UP Brain Health Support Program
Comparing Traditional and Digital Cognitive Assessments in an Online Dementia Risk Reduction Program: Results from the CAN‐THUMBS‐UP Brain Health Support Program Open
Background The CAN‐THUMBS‐UP Brain Health Support Program (BHP; NCT05347966), a year‐long web‐based dementia risk reduction study, included two self‐administered digital cognitive assessments as exploratory outcomes. Cogniciti's Brain Heal…
View article: Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol
Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol Open
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and mi…
View article: GENETIC RISK, MODIFIABLE FACTORS, AND COGNITIVE PERFORMANCE IN MIDDLE- AND OLDER-AGED CANADIANS
GENETIC RISK, MODIFIABLE FACTORS, AND COGNITIVE PERFORMANCE IN MIDDLE- AND OLDER-AGED CANADIANS Open
Whether the apolipoprotein E (APOE) e4 allele interacts with modifiable factors to predict cognitive performance is unclear. This study examined 26,448 participants (45 to 86 years of age at baseline) in the Canadian Longitudinal Study on …
View article: Exploring the impact of pediatric OCD on family impairment: A consideration of parent, sibling, and affected-child perspectives
Exploring the impact of pediatric OCD on family impairment: A consideration of parent, sibling, and affected-child perspectives Open
By providing sibling perspectives within the same family unit, this study expands upon previous findings that accommodation predicts family impairment from parent and child perspectives. Our study highlights factors relevant to family-base…
View article: Individual socioeconomic status, neighborhood disadvantage, and cognitive aging: A longitudinal analysis of the <scp>CLSA</scp>
Individual socioeconomic status, neighborhood disadvantage, and cognitive aging: A longitudinal analysis of the <span>CLSA</span> Open
Background There are likely many contributors to variation in the rate of cognitive decline in middle and late adulthood, including individual and neighborhood socio‐economic factors. This study examines whether individual socio‐economic f…
View article: Personal value of Alzheimer's disease biomarker testing and result disclosure from the patient and care partner perspective
Personal value of Alzheimer's disease biomarker testing and result disclosure from the patient and care partner perspective Open
INTRODUCTION We described patients’ and care partners’ experiences with Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker testing and result disclosure in routine care. METHODS IMPACT‐AD BC is an observational study of clinic pa…
View article: Clinical value of Alzheimer's disease biomarker testing
Clinical value of Alzheimer's disease biomarker testing Open
INTRODUCTION In the Investigating the Impact of Alzheimer's Disease Diagnostics in British Columbia (IMPACT‐AD BC) study, we aimed to understand how Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker testing—used in medical care—…
View article: Cross-sectional and longitudinal neural predictors of physical activity and sedentary behaviour from a 6-month randomized controlled trial
Cross-sectional and longitudinal neural predictors of physical activity and sedentary behaviour from a 6-month randomized controlled trial Open
A sedentary lifestyle offers immediate gratification, but at the expense of long-term health. It is thus critical to understand how the brain evaluates immediate rewards and long-term health effects in the context of deciding whether to en…
View article: Exercise training mitigates the deleterious effects of experimental bed rest on intraindividual variability of executive functioning in older adults: A randomised controlled trial
Exercise training mitigates the deleterious effects of experimental bed rest on intraindividual variability of executive functioning in older adults: A randomised controlled trial Open
Background In older adults, bed rest can occur because of chronic conditions, injury, surgery, or hospitalization. Extreme levels of physical inactivity due to bed rest initiate a downward spiral in several body systems. Exercise is a coun…
View article: Reshaping the path of vascular cognitive impairment with progressive resistance training: A 12‐Month Randomized Trial
Reshaping the path of vascular cognitive impairment with progressive resistance training: A 12‐Month Randomized Trial Open
Background Subcortical ischaemic vascular cognitive impairment (SIVCI) is the most common form of vascular cognitive impairment. Importantly, SIVCI is considered the most treatable form of cognitive impairment, due to its modifiable risk f…
View article: Physical activity attenuates the effect of poor sleep quality on cognitive function in adults with chronic stroke
Physical activity attenuates the effect of poor sleep quality on cognitive function in adults with chronic stroke Open
Background Good sleep quality is important for cognitive health. Individuals with chronic stroke are at an increased risk for dementia and about half have insomnia. Stroke survivors are a target population in need of intervention strategie…
View article: Baseline Cognitive Performance Is a Determinant of Prospective Health Resource Utilization Among Adults with Chronic Stroke: A Secondary Analysis
Baseline Cognitive Performance Is a Determinant of Prospective Health Resource Utilization Among Adults with Chronic Stroke: A Secondary Analysis Open
Background Cognitive impairment is a costly public health problem globally. Among older adults with chronic stroke, the literature is devoid of prospective data that identify factors responsible for driving health care resource utilization…
View article: Economic Evaluation of Exercise or Cognitive and Social Enrichment Activities for Improved Cognition After Stroke
Economic Evaluation of Exercise or Cognitive and Social Enrichment Activities for Improved Cognition After Stroke Open
Importance Cognitive impairment is prevalent in survivors of stroke, affecting approximately 30% of individuals. Physical exercise and cognitive and social enrichment activities can enhance cognitive function in patients with chronic strok…
View article: On prospective resilience methods and precision medicine approaches
On prospective resilience methods and precision medicine approaches Open
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View article: Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol
Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol Open
Obsessive‐compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and mi…
View article: Worsened Ability to Engage in Social and Physical Activity During the COVID-19 Pandemic and Older Adults’ Mental Health: Longitudinal Analysis From the Canadian Longitudinal Study on Aging
Worsened Ability to Engage in Social and Physical Activity During the COVID-19 Pandemic and Older Adults’ Mental Health: Longitudinal Analysis From the Canadian Longitudinal Study on Aging Open
Background and Objectives Restrictions implemented to mitigate the transmission of coronavirus disease 2019 (COVID-19) affected older adults’ ability to engage in social and physical activities. We examined mental health outcomes of older …
View article: Contributors to mental health resilience in middle-aged and older adults: an analysis of the Canadian Longitudinal Study on Aging
Contributors to mental health resilience in middle-aged and older adults: an analysis of the Canadian Longitudinal Study on Aging Open
The burden of poor mental health in aging adults may be alleviated through targeted interventions involving physical activity and social connectedness for individuals with lower socioeconomic resources.
View article: Predictors of the rate of cognitive decline in older adults using machine learning
Predictors of the rate of cognitive decline in older adults using machine learning Open
Background The longitudinal rates of cognitive decline among aging populations are heterogeneous. Few studies have investigated the possibility of implementing prognostic models to predict cognitive changes with the combination of categori…
View article: Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol
Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol Open
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and mi…
View article: Bidirectional Associations Between Adiposity and Cognitive Function and Mediation by Brain Morphology in the ABCD Study
Bidirectional Associations Between Adiposity and Cognitive Function and Mediation by Brain Morphology in the ABCD Study Open
Importance Most epidemiologic studies examine the brain as an outcome in relation to adiposity (ie, the brain-as-outcome perspective), but it is also a potential risk factor associated with adiposity accumulation over time (ie, the brain-a…