Explanipedia

Transient vision and intraocular pressure changes following anti-vascular endothelial growth factor injection Open

Khaldon Abbas, Amy Basilious, Julie Duncan, Tom Sheidow, Philip L. Hooper , et al. · 2025

Use of serum long non-coding RNA expression panel as a marker for diabetic retinopathy Open

Eric Wang, Shali Chen, Arshad Ali, Biao Feng, Selina L. Liu , et al. · 2025

Introduction Diabetic retinopathy (DR) is the most common chronic complication of diabetes, the leading cause of vision impairments in working-aged adults, and a significant cause of reduced quality of life for diabetic patients. Diabetic …

Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial Open

Arshad M. Khanani, Sunil Patel, Giovanni Staurenghi, Ramin Tadayoni, Carl J. Danzig , et al. · 2023

Effectiveness of non-mydriatic ultra-widefield retinal imaging to screen for diabetic eye disease: a randomized controlled trial (Clearsight) Open

Selina L. Liu, John R. Gonder, Ehsan Owrangi, Neil Klar, Irene Hramiak , et al. · 2022

Objective Suboptimal diabetic eye disease screening is a major cause of preventable vision loss. Screening barriers include mydriasis and need for dedicated screening appointments. The Clearsight trial assessed whether non-mydriatic ultr…

Effectiveness of non-mydriatic ultra-widefield retinal imaging to screen for diabetic eye disease: a randomized controlled trial (Clearsight) Open

Selina L. Liu, John R. Gonder, Ehsan Owrangi, Neil Klar, Irene Hramiak , et al. · 2022

Objective Suboptimal diabetic eye disease screening is a major cause of preventable vision loss. Screening barriers include mydriasis and need for dedicated screening appointments. The Clearsight trial assessed whether non-mydriatic ultr…

Expressions of Serum lncRNAs in Diabetic Retinopathy – A Potential Diagnostic Tool Open

Saumik Biswas, Ali Coyle, Shali Chen, Mišo Gostimir, John R. Gonder , et al. · 2022

With increasing incidence of diabetes worldwide, there is an ever-expanding number of patients with chronic diabetic complications such as diabetic retinopathy (DR), one of the leading causes of blindness in the working age population. Ear…

The Long Non-Coding RNA <i>HOTAIR</i> Is a Critical Epigenetic Mediator of Angiogenesis in Diabetic Retinopathy Open

Saumik Biswas, Biao Feng, Shali Chen, Jieting Liu, Erfan Aref‐Eshghi , et al. · 2021

Our findings suggest that HOTAIR is a critical lncRNA in the pathogenesis of DR and may potentially be important for diagnostic and therapeutic targeting.

Novel Long non-coding RNA mediated EndMT pathway in the retina in diabetes Open

Subrata Chakrabarti, Anu Thomas, Saumik Biswas, Biao Feng, Shali Chen , et al. · 2019

Two-year analysis of changes in the optic nerve and retina following anti-VEGF treatments in diabetic macular edema patients Open

Richard Filek, Philip L. Hooper, Sheidow TG, John R. Gonder, Subrata Chakrabarti , et al. · 2019

Richard Filek,1 Phil Hooper2,3 Tom G Sheidow2,3 John Gonder2,3 Subrata Chakrabarti,1 Cindy ML Hutnik1–31Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada; 2Department of Ophthalmology, Western Universi…

Two-year analysis of changes in the optic nerve and retina following anti-VEGF treatments in diabetic macular edema patients Open

Richard Filek, Phil Hooper, Tom Sheidow, John R. Gonder, Subrata Chakrabarti , et al. · 2019

Purpose: To evaluate long-term structural and functional changes that happen to the optic nerve and retina following ranibizumab (Lucentis) injections in diabetic macular edema (DME) patients. Methods: Patients with clinicall…

Vision-Related Quality of Life in Patients with Diabetic Macular Edema Treated with Intravitreal Aflibercept Open

Justus G. Garweg, Jana Štefaničková, Carel C B Hoyng, Thomas Schmelter, Tobias Niesen , et al. · 2019

lncRNA H19 prevents endothelial–mesenchymal transition in diabetic retinopathy Open

Anu Thomas, Saumik Biswas, Biao Feng, Shali Chen, John R. Gonder , et al. · 2019

MALAT1: An Epigenetic Regulator of Inflammation in Diabetic Retinopathy Open

Saumik Biswas, Anu Thomas, Shali Chen, Erfan Aref‐Eshghi, Biao Feng , et al. · 2018

Despite possessing limited protein-coding potential, long non-coding RNAs (lncRNAs) have been implicated in a myriad of pathologic conditions. Most well documented in cancer, one prominent intergenic lncRNA known as MALAT1 is notorious for…

A randomised trial of non-mydriatic ultra-wide field retinal imaging versus usual care to screen for diabetic eye disease: rationale and protocol for the Clearsight trial Open

Selina L. Liu, Lewis W Mahon, Neil Klar, David C. Schulz, John R. Gonder , et al. · 2017

Introduction Suboptimal screening for diabetic eye disease is a major cause of preventable vision loss. Screening barriers include mydriasis and the extra time patients need to attend dedicated eye screening appointments. In the Clearsight…

A Clinico-Pathological Study of the Structural and Functional Changes to the Retina and Optic Nerve following anti-VEGF Treatments for Diabetic Macular Edema Open

Richard Filek, Phil Hooper, Tom Sheidow, John R. Gonder, Subrata Chakrabarti , et al. · 2017

Structural and functional changes to the retina and optic nerve following panretinal photocoagulation over a 2-year time period Open

Richard Filek, Philip L. Hooper, Tom Sheidow, John R. Gonder, Dixit Varma , et al. · 2017

Investigating the Structural and Functional Changes to the Retina Following Pan-Retinal Photocoagulation in Diabetic Retinopathy Patients Open

Richard Filek, Phil Hooper, Tom Sheidow, John R. Gonder, Subrata Chakrabarti , et al. · 2016

A case of unilateral and spontaneously resolving posterior uveitis with overlapping features of Vogt–Koyanagi–Harada disease and Acute Posterior Multifocal Placoid Pigment Epitheliopathy Open

Bo Li, Ricarda J. Bentham, John R. Gonder · 2016

The imaging and clinical findings of both VKH disease and APMPPE raise the notion that VKH disease and APMPPE could be an overlapping spectrum of inflammatory processes, rather than distinct disease entities.

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