John R. Halliwill
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View article: Histamine‐receptor blockade does not influence the heavy‐severe domain boundary and time to task failure in the severe domain during cycling exercise in adults
Histamine‐receptor blockade does not influence the heavy‐severe domain boundary and time to task failure in the severe domain during cycling exercise in adults Open
The influence of histamine in skeletal muscle during exercise is poorly characterized. This investigation tested the hypothesis that histamine‐receptor blockade lowers the power associated with the heavy‐severe domain boundary and reduces …
View article: Systemic cardiovascular and carotid baroreflex support of arterial pressure during recovery from passive heat stress in young and older adults
Systemic cardiovascular and carotid baroreflex support of arterial pressure during recovery from passive heat stress in young and older adults Open
We evaluated the systemic cardiovascular and carotid baroreflex support of arterial pressure during recovery from whole‐body, passive heating in young and older adults. Supine mean arterial pressure (MAP), cardiac output (Q; acetylene wash…
View article: Exogenous estradiol increases cardiovagal baroreflex sensitivity during a hypertensive stimulus in premenopausal young women
Exogenous estradiol increases cardiovagal baroreflex sensitivity during a hypertensive stimulus in premenopausal young women Open
Attenuated cardiovagal baroreflex sensitivity is associated with cardiovascular disease. Female sex hormones have a significant impact on the development of cardiovascular disease across the lifespan. Using an experimental model of hormone…
View article: No effect of either heat therapy or aerobic exercise training on blood pressure in adults with untreated hypertension: a randomized clinical trial
No effect of either heat therapy or aerobic exercise training on blood pressure in adults with untreated hypertension: a randomized clinical trial Open
Exercise training represents a crucial lifestyle intervention for improving blood pressure, yet many adults do not meet recommendations for physical activity. Heat therapy was tested against aerobic exercise training as a potential alterna…
View article: Histamine is a molecular transducer of adaptation to endurance exercise training in humans
Histamine is a molecular transducer of adaptation to endurance exercise training in humans Open
Histamine appears to be intimately involved with skeletal muscle responses during and following exercise. Blocking histamine’s actions during endurance exercise training by taking common over-the-counter antihistamines resulted in diminish…
View article: Comparison of thermoregulatory, cardiovascular, and immune responses to different passive heat therapy modalities
Comparison of thermoregulatory, cardiovascular, and immune responses to different passive heat therapy modalities Open
Our goal was to compare three widely utilized modalities of passive heating in the manner that they are most commonly used for heat therapy. We have demonstrated that hot water immersion leads to the greatest thermoregulatory, cardiovascul…
View article: Muscle temperature increases during a single far infrared sauna session without changes in intestinal temperature
Muscle temperature increases during a single far infrared sauna session without changes in intestinal temperature Open
To our knowledge, this is the first investigation on far infrared sauna bathing with a commercially available sauna and muscle temperature. Muscle temperature increased in the absence of changes in core temperature. The increases in muscle…
View article: Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk
Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk Open
View article: Gut feelings on short-chain fatty acids to regulate respiratory health
Gut feelings on short-chain fatty acids to regulate respiratory health Open
Respiratory infections and diseases pose significant challenges to society and healthcare systems, underscoring the need for preventative and therapeutic strategies. Recent research in rodent models indicates that short-chain fatty acids (…
View article: Acute exposure to carbon monoxide inhalation and/or hot water immersion transiently increases erythropoietin in females but not in males
Acute exposure to carbon monoxide inhalation and/or hot water immersion transiently increases erythropoietin in females but not in males Open
The use of acute carbon monoxide inhalation (COi) and hot water immersion (HWI) are of growing interest as interventions to stimulate erythropoietin (EPO) production. However, whether EPO production is further augmented when combining thes…
View article: Measuring renal hemodynamics during exercise using doppler ultrasound
Measuring renal hemodynamics during exercise using doppler ultrasound Open
Dynamic exercise causes a sympathetically mediated reduction in renal blood flow (Rocha et al., 2023). Blood is redistributed away from the renal vascular beds to support the increased metabolic demand of the working skeletal muscle and th…
View article: Effect of histamine‐receptor antagonism on the circulating inflammatory cell and cytokine response to exercise: A pilot study
Effect of histamine‐receptor antagonism on the circulating inflammatory cell and cytokine response to exercise: A pilot study Open
The purpose of this study was to gain insight into histamine's role in the exercise inflammatory response and recovery from exercise. To explore this, young healthy participants ( n = 12) performed 300 eccentric leg extensions under contro…
View article: Hypohydration attenuates increases in creatinine clearance to oral protein loading and the renal hemodynamic response to exercise pressor reflex
Hypohydration attenuates increases in creatinine clearance to oral protein loading and the renal hemodynamic response to exercise pressor reflex Open
Insufficient hydration is prevalent among free living adults. This study found that hypohydration induced by 24-h fluid deprivation engaged renal functional reserve and that oral protein loading did not further increase creatinine clearanc…
View article: Cardiovascular and mood responses to an acute bout of cold water immersion
Cardiovascular and mood responses to an acute bout of cold water immersion Open
View article: Data set for cardiovascular and mood responses to an acute bout of cold water immersion
Data set for cardiovascular and mood responses to an acute bout of cold water immersion Open
Data set for manuscript.
View article: Data set for cardiovascular and mood responses to an acute bout of cold water immersion
Data set for cardiovascular and mood responses to an acute bout of cold water immersion Open
Data set for manuscript.
View article: Acute kidney injury biomarkers and hydration assessments following prolonged mild hypohydration in healthy young adults
Acute kidney injury biomarkers and hydration assessments following prolonged mild hypohydration in healthy young adults Open
This study found that prolonged mild hypohydration in healthy young adults increased the Food and Drug Administration approved acute kidney injury (AKI) biomarker urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of…
View article: Supplemental Table S1
Supplemental Table S1 Open
24-h pre-experimental trial dietary analysis.
View article: Supplemental Table S1
Supplemental Table S1 Open
24-h pre-experimental trial dietary analysis.
View article: Transcutaneous delivery of sodium bicarbonate increases intramuscular pH
Transcutaneous delivery of sodium bicarbonate increases intramuscular pH Open
Introduction: Oral bicarbonate loading improves the buffering of metabolic acidosis and may improve exercise performance but can also result in gastric distress. Momentous’ PR Lotion contains a novel composition intended to provide a trans…
View article: Cholinergic nerve contribution to cutaneous active vasodilation during exercise is similar to whole body passive heating
Cholinergic nerve contribution to cutaneous active vasodilation during exercise is similar to whole body passive heating Open
Our study establishes the primacy of cholinergic nerves to cutaneous active vasodilation during exercise and confirms this model during passive heating using a crossover study design. In addition, the mode of heating, whether passive or ex…
View article: Sex Differences in VO2max and the Impact on Endurance-Exercise Performance
Sex Differences in VO2max and the Impact on Endurance-Exercise Performance Open
It was not until 1984 that women were permitted to compete in the Olympic marathon. Today, more women than men participate in road racing in all distances except the marathon where participation is near equal. From the period of 1985 to 20…
View article: The effect of local passive heating on skeletal muscle histamine concentration: implications for exercise-induced histamine release
The effect of local passive heating on skeletal muscle histamine concentration: implications for exercise-induced histamine release Open
The “exercise signal” that triggers histamine release within active skeletal muscle during aerobic exercise is unknown. By mimicking the magnitude and time course of increasing skeletal muscle temperature observed during aerobic exercise, …
View article: Brachial and carotid hemodynamic response to hot water immersion in men and women
Brachial and carotid hemodynamic response to hot water immersion in men and women Open
This study sought to compare the brachial and carotid hemodynamic response to hot water immersion (HWI) between healthy young men and women. Ten women (W) and 11 men (M) (24 ± 4 yr) completed a 60-min HWI session immersed to the level of t…
View article: The impact of elevated body core temperature on critical power as determined by a 3-min all-out test
The impact of elevated body core temperature on critical power as determined by a 3-min all-out test Open
The parameters of the power-duration relationship (critical power and W′) estimated by a 3-min all-out test were not altered by elevated body core temperature as compared with a thermoneutral condition.
View article: Comparison of morning versus evening aerobic-exercise training on heart rate recovery in treated hypertensive men: a randomized controlled trial
Comparison of morning versus evening aerobic-exercise training on heart rate recovery in treated hypertensive men: a randomized controlled trial Open
Heart rate recovery (HRR) is a marker of cardiac autonomic regulation and an independent predictor of mortality. Aerobic-exercise training conducted in the evening (evening training) produces greater improvement in resting cardiac autonomi…
View article: Hemodynamics of postexercise versus post-hot water immersion recovery
Hemodynamics of postexercise versus post-hot water immersion recovery Open
Hot water immersion resulted in a postintervention hypotension similar to that observed following exercise matched for time and core temperature rise, but with greater reductions in brachial retrograde shear. Heating was associated with lo…
View article: A brief history of the Physiology Majors Interest Group (P-MIG)
A brief history of the Physiology Majors Interest Group (P-MIG) Open
View article: The case for coordinating efforts to establish program guidelines and strengthen physiology undergraduate degree programs
The case for coordinating efforts to establish program guidelines and strengthen physiology undergraduate degree programs Open
View article: Effect of histamine-receptor antagonism on leg blood flow during exercise
Effect of histamine-receptor antagonism on leg blood flow during exercise Open
Leg blood flow during exercise was increased by taking antihistamines, which block the receptors for histamine, a molecule often associated with inflammatory and immune responses. The elevated blood flow occurred over exercise intensities …