John R. Matyas
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View article: Collagen integrity of the annulus fibrosus in degenerative disc disease individuals quantified with collagen hybridizing peptide
Collagen integrity of the annulus fibrosus in degenerative disc disease individuals quantified with collagen hybridizing peptide Open
Introduction Degenerative disc disease (DDD) is accompanied by structural changes in the intervertebral discs (IVD). Extra‐cellular matrix degradation of the annulus fibrosus (AF) has been linked with degeneration of the IVD. Collagen is a…
View article: Skin regeneration is enabled in the absence of fibroblast inflammatory priming
Skin regeneration is enabled in the absence of fibroblast inflammatory priming Open
In adult mammals, skin wound healing has evolved to favor rapid repair through the formation of fibrotic scar. These dermal scars are dysfunctional and may lead to chronic disfigurement and disability, yet the biologic mechanisms that driv…
View article: Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer Open
View article: Issue Information
Issue Information Open
Automatic detection and voxel-wise mapping of
View article: Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity
Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity Open
Aggrecan is a critical component of the extracellular matrix of all cartilages. One of the early hallmarks of osteoarthritis (OA) is the loss of aggrecan from articular cartilage followed by degeneration of the tissue. Mesenchymal progenit…
View article: <scp>IL‐1Ra</scp> deficiency accelerates intervertebral disc degeneration in <scp>C57BL6J</scp> mice
<span>IL‐1Ra</span> deficiency accelerates intervertebral disc degeneration in <span>C57BL6J</span> mice Open
The expression of Interleukin‐1ß (IL‐1ß) and its antagonist and Interleukin‐1 receptor antagonist (IL‐1Ra) are correlated with greater human intervertebral disc (IVD) degeneration, suggesting that elevated IL‐1β activity promotes disc dege…
View article: Altered activity of pain processing brain regions in association with hip osteoarthritis
Altered activity of pain processing brain regions in association with hip osteoarthritis Open
View article: Skin regeneration is enabled in the absence of fibroblast inflammatory priming
Skin regeneration is enabled in the absence of fibroblast inflammatory priming Open
In adult mammals, skin wound healing has evolved to favor rapid repair through the formation of fibrotic scar. These dermal scars are dysfunctional and may lead to chronic disfigurement and disability, yet the biologic mechanisms that driv…
View article: Skin regeneration is enabled in the absence of fibroblast inflammatory priming
Skin regeneration is enabled in the absence of fibroblast inflammatory priming Open
In adult mammals, skin wound healing has evolved to favor rapid repair through the formation of fibrotic scar. These dermal scars are dysfunctional and may lead to chronic disfigurement and disability, yet the biologic mechanisms that driv…
View article: Skin regeneration is enabled in the absence of fibroblast inflammatory priming
Skin regeneration is enabled in the absence of fibroblast inflammatory priming Open
In adult mammals, skin wound healing has evolved to favor rapid repair through the formation of fibrotic scar. These dermal scars are dysfunctional and may lead to chronic disfigurement and disability, yet the biologic mechanisms that driv…
View article: Fibroblast polarization drives skin regeneration versus fibrosis in adult reindeer
Fibroblast polarization drives skin regeneration versus fibrosis in adult reindeer Open
In adult mammals, skin wound healing has evolved to favor rapid repair through the formation of fibrotic scar. These dermal scars are dysfunctional and may lead to chronic disfigurement and disability, yet the biologic mechanisms that driv…
View article: Long-term modulation of airway remodelling in severe asthma following bronchial thermoplasty
Long-term modulation of airway remodelling in severe asthma following bronchial thermoplasty Open
Rationale Bronchial thermoplasty is a mechanical therapeutic intervention that has been advocated as an effective treatment option for severe asthma. The mechanism is promoted as being related to the attenuation of airway smooth muscle whi…
View article: Review for "Associations between pain catastrophizing and resting‐state functional brain connectivity: Ethnic/race group differences in persons with chronic knee pain"
Review for "Associations between pain catastrophizing and resting‐state functional brain connectivity: Ethnic/race group differences in persons with chronic knee pain" Open
View article: Role of Primary Afferents in Arthritis Induced Spinal Microglial Reactivity
Role of Primary Afferents in Arthritis Induced Spinal Microglial Reactivity Open
Increased afferent input resulting from painful injury augments the activity of central nociceptive circuits via both neuron-neuron and neuron-glia interactions. Microglia, resident immune cells of the central nervous system (CNS), play a …
View article: Repetitive in vivo manual loading of the spine elicits cellular responses in porcine annuli fibrosi
Repetitive in vivo manual loading of the spine elicits cellular responses in porcine annuli fibrosi Open
Back pain and intervertebral disc degeneration are prevalent, costly, and widely treated by manual therapies, yet the underlying causes of these diseases are indeterminate as are the scientific bases for such treatments. The present studie…
View article: Fibroblast polarization drives skin regeneration versus fibrosis in adult reindeer
Fibroblast polarization drives skin regeneration versus fibrosis in adult reindeer Open
In adult mammals, skin wound healing has evolved to favor rapid repair through the formation of fibrotic scar. These dermal scars are dysfunctional and may lead to chronic disfigurement and disability, yet the biologic mechanisms that driv…
View article: Fibroblast polarization drives skin regeneration versus fibrosis in adult reindeer
Fibroblast polarization drives skin regeneration versus fibrosis in adult reindeer Open
In adult mammals, skin wound healing has evolved to favor rapid repair through the formation of fibrotic scar. These dermal scars are dysfunctional and may lead to chronic disfigurement and disability, yet the biologic mechanisms that driv…
View article: Cage-lid hanging behavior as a translationally relevant measure of pain in mice
Cage-lid hanging behavior as a translationally relevant measure of pain in mice Open
The development of new analgesic drugs has been hampered by the inability to translate preclinical findings to humans. This failure is due in part to the weak connection between commonly used pain outcome measures in rodents and the clinic…
View article: Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction
Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction Open
The major milestones in mouse placental development are well described, but our understanding is limited to how the placenta can adapt to damage or changes in the environment. By using stereology and expression of cell cycle markers, we fo…
View article: Serum-Free Culture of Human Mesenchymal Stem Cell Aggregates in Suspension Bioreactors for Tissue Engineering Applications
Serum-Free Culture of Human Mesenchymal Stem Cell Aggregates in Suspension Bioreactors for Tissue Engineering Applications Open
Mesenchymal stem cells (MSCs) have the capacity to differentiate towards bone, fat, and cartilage lineages. The most widely used culture and differentiation protocols for MSCs are currently limited by their use of serum-containing media an…
View article: Microglial pannexin-1 channel activation is a spinal determinant of joint pain
Microglial pannexin-1 channel activation is a spinal determinant of joint pain Open
A new therapeutic option for treating arthritis pain.
View article: Correction to: LyP-1 Conjugated Nanoparticles for Magnetic Resonance Imaging of Triple Negative Breast Cancer
Correction to: LyP-1 Conjugated Nanoparticles for Magnetic Resonance Imaging of Triple Negative Breast Cancer Open
View article: Enumeration and Localization of Mesenchymal Progenitor Cells and Macrophages in Synovium from Normal Individuals and Patients with Pre-Osteoarthritis or Clinically Diagnosed Osteoarthritis
Enumeration and Localization of Mesenchymal Progenitor Cells and Macrophages in Synovium from Normal Individuals and Patients with Pre-Osteoarthritis or Clinically Diagnosed Osteoarthritis Open
Osteoarthritis (OA) is a degenerative disorder characterized by chondrocyte apoptosis and degeneration of articular cartilage resulting in loss of mobility and pain. Inflammation plays a key role in the development and progression of OA bo…
View article: Meniscus Induced Cartilaginous Damage and Non-linear Gross Anatomical Progression of Early-stage Osteoarthritis in a Canine Model
Meniscus Induced Cartilaginous Damage and Non-linear Gross Anatomical Progression of Early-stage Osteoarthritis in a Canine Model Open
Background: The predictable outcome of the anterior cruciate ligament transection (ACLT) canine model, and the similarity to naturally occurring osteoarthritis (OA) in humans, provide a translatable method for studying OA. Still, evidence …
View article: Intra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model
Intra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model Open
Controversy remains whether articular cartilage has an endogenous stem/progenitor cell population, since its poor healing capacity after injury can lead to diseases such as osteoarthritis. In the joint environment there are mesenchymal ste…
View article: Topographical variations in zonal properties of canine tibial articular cartilage due to early osteoarthritis: a study using 7-T magnetic resonance imaging at microscopic resolution
Topographical variations in zonal properties of canine tibial articular cartilage due to early osteoarthritis: a study using 7-T magnetic resonance imaging at microscopic resolution Open
View article: Effect of disulfide bonding and multimerization on proteoglycan 4’s cartilage boundary lubricating ability and adsorption
Effect of disulfide bonding and multimerization on proteoglycan 4’s cartilage boundary lubricating ability and adsorption Open
These results demonstrate that the intermolecular disulfide-bonded multimeric structure of PRG4 is important for its ability to adsorb to a cartilage surface and function as a boundary lubricant. These findings contribute to a greater unde…
View article: (321) Role of microglia and P2X7 receptors in arthritis pain
(321) Role of microglia and P2X7 receptors in arthritis pain Open
View article: The Role of Gap Junctions and Mechanical Loading on Mineral Formation in a Collagen-I Scaffold Seeded with Osteoprogenitor Cells
The Role of Gap Junctions and Mechanical Loading on Mineral Formation in a Collagen-I Scaffold Seeded with Osteoprogenitor Cells Open
Fracture nonunions represent one of many large bone defects where current treatment strategies fall short in restoring both form and function of the injured tissue. In this case, the use of a tissue-engineered scaffold for promoting bone h…