John S. Duncan
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View article: Multimodal integration of magnetic resonance imaging and intracranial electroencephalographic abnormalities in temporal lobe epilepsy surgery
Multimodal integration of magnetic resonance imaging and intracranial electroencephalographic abnormalities in temporal lobe epilepsy surgery Open
Objective Precise localization of epileptogenic tissue is critical for successful surgery in drug‐resistant temporal lobe epilepsy (TLE) but is challenging in those requiring intracranial electroencephalography (iEEG). A range of modalitie…
View article: Mapping white matter tracts with <scp>SEEG</scp> electrodes
Mapping white matter tracts with <span>SEEG</span> electrodes Open
Objective Stereo‐electroencephalography (SEEG) is designed to record gray matter (GM) activity for epileptogenic zone localization. SEEG electrodes, however, traverse white matter (WM) pathways that connect regions involved in seizure netw…
View article: Hippocampal abnormality and response to vagus nerve stimulation in epilepsy
Hippocampal abnormality and response to vagus nerve stimulation in epilepsy Open
Vagus nerve stimulation (VNS) reduces seizure frequency and severity in some, but not all, individuals with epilepsy. The hippocampus has been implicated in VNS response, but is yet to be studied structurally using T1‐weighted (T1w) magnet…
View article: Multi-voxel pattern analysis of face and word encoding fMRI in people with temporal lobe epilepsy and healthy individuals
Multi-voxel pattern analysis of face and word encoding fMRI in people with temporal lobe epilepsy and healthy individuals Open
Memory functional MRI (fMRI) has been used to explore cognitive processing in people with refractory temporal lobe epilepsy (TLE) to predict memory decline after anterior temporal lobe resection (ATLR). Traditional studies employed univari…
View article: Outcomes of surgically and non-surgically managed temporal encephalocoeles in the context of drug-resistant temporal lobe epilepsy: A retrospective single-centre case series
Outcomes of surgically and non-surgically managed temporal encephalocoeles in the context of drug-resistant temporal lobe epilepsy: A retrospective single-centre case series Open
Our study demonstrates that excellent post-operative outcomes are achievable with temporal lobe resections. A standardised presurgical evaluation pathway and management protocol are essential to ensure timely identification of temporal enc…
View article: Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy
Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy Open
This study highlights that patients with TLE exhibit more pronounced and widespread gray and white matter atrophy across the lifespan. The cross-sectional nature of our study limits definitive conclusions on whether the atrophy shown is pr…
View article: Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain
Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain Open
Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic brain regions, they often neglect age and sex effe…
View article: Longitudinal Assessment of Cone Structure, Choriocapillaris, and Retinal Sensitivity in Choroideremia
Longitudinal Assessment of Cone Structure, Choriocapillaris, and Retinal Sensitivity in Choroideremia Open
Cone spacing z score increased uniformly within the residual macular area, and CCFD and retinal sensitivity changed more rapidly within 1° of the FAF border. Regions in this zone are projected to lose 7 dB of sensitivity in approximately 3…
View article: Progression of Dark-Adapted Visual Fields Over 3 Years in the Rate of Progression in <i>USH2A</i>-Related Retinal Degeneration (RUSH2A) Study
Progression of Dark-Adapted Visual Fields Over 3 Years in the Rate of Progression in <i>USH2A</i>-Related Retinal Degeneration (RUSH2A) Study Open
Average yearly change in mean DAVF measures was comparable with the annual change on full-field stimulus testing and faster than in cone-mediated measures. Two-color DAVFs identified rod-mediated function in the majority of patients with U…
View article: Associations between epilepsy-related polygenic risk and brain morphology in childhood
Associations between epilepsy-related polygenic risk and brain morphology in childhood Open
Extensive neuroimaging research in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) has identified brain atrophy as a disease phenotype. While it is also related to a complex genetic architecture, the transition from genetic risk…
View article: Brain Damage During New-Onset Refractory Status Epilepticus
Brain Damage During New-Onset Refractory Status Epilepticus Open
Status epilepticus (SE) has long been linked to neuronal damage in experimental and animal studies, yet direct human evidence remains scarce. The risk of seizure-induced brain injury is central to the definition, urgency, treatment, and pr…
View article: Terpene‐Maleate Based Resins for Stereolithography: Advancing Sustainable 3D Printing
Terpene‐Maleate Based Resins for Stereolithography: Advancing Sustainable 3D Printing Open
Additive Manufacturing (AM), particularly stereolithography (SLA), offers great flexibility for producing complex structures. However, the limited availability of photocurable and sustainable resins remains a major challenge. Therefore, th…
View article: Long‐term survival after adult epilepsy surgery: Mortality and predictors in a large cohort
Long‐term survival after adult epilepsy surgery: Mortality and predictors in a large cohort Open
Objective Long‐term survival data in adults undergoing surgery for drug‐resistant focal epilepsy remain limited. We examined mortality patterns and predictors in a large cohort followed for over 30 years. Methods Adults who underwent epile…
View article: Enablers and Barriers to Integrating Advance Care Planning in Chronic Kidney Disease Care in a Canadian Provincial Network
Enablers and Barriers to Integrating Advance Care Planning in Chronic Kidney Disease Care in a Canadian Provincial Network Open
Background: Individuals with advanced chronic kidney disease benefit from an integrated palliative approach to care through timely advance care planning and discussions about their goals of care. Despite literature and guidelines emphasizi…
View article: Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery
Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery Open
Objective Drug‐resistant focal epilepsy is associated with abnormalities in the brain in both gray matter (GM) and superficial white matter (SWM). However, it is unknown if both types of abnormalities are important in supporting seizures. …
View article: Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities
Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities Open
Objective Successful epilepsy surgery requires accurate localization and removal of the epileptogenic zone. Neuroimaging helps detect structural brain abnormalities to guide surgery, but current clinical practice does not use diffusion‐wei…
View article: Evaluation of Navify Mutation Profiler Tertiary Analysis Software Assessing for Hematologic Malignancies
Evaluation of Navify Mutation Profiler Tertiary Analysis Software Assessing for Hematologic Malignancies Open
Background: Navify® Mutation Profiler (Navify MP) is a cloud-based, tertiary analysis software that provides curation, annotation, and reporting of somatic genomic alterations and biomarker signatures identified by next-generation sequenci…
View article: Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers
Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers Open
Objective Children with refractory focal epilepsy differ from adults, although many centers will offer invasive electroencephalography (iEEG) to both. Outcomes in terms of likelihood of resection and subsequent seizure outcome after either…
View article: Using Foundation Models as Pseudo-Label Generators for Pre-Clinical 4D Cardiac CT Segmentation
Using Foundation Models as Pseudo-Label Generators for Pre-Clinical 4D Cardiac CT Segmentation Open
Cardiac image segmentation is an important step in many cardiac image analysis and modeling tasks such as motion tracking or simulations of cardiac mechanics. While deep learning has greatly advanced segmentation in clinical settings, ther…
View article: High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases
High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases Open
Participants adopt eccentric PRLs with hyporeflective cones and reduced sensitivity despite more sensitive and normal-appearing cones at greater eccentricities, suggesting that foveal proximity is prioritized over cone integrity in establi…
View article: Distinct gray matter and metabolic characteristics in hypothalamic hamartoma network with different semiology
Distinct gray matter and metabolic characteristics in hypothalamic hamartoma network with different semiology Open
Objective Hypothalamic hamartomas (HHs) are developmental malformations associated with focal epilepsy. We investigated the patterns of gray matter morphology and cerebral metabolism in individuals with HHs, with and without focal to bilat…
View article: Association of the Timing and Type of Acute Symptomatic Seizures With Poststroke Epilepsy and Mortality
Association of the Timing and Type of Acute Symptomatic Seizures With Poststroke Epilepsy and Mortality Open
BACKGROUND: Acute symptomatic seizures (ASyS) increase the risk of epilepsy and mortality after a stroke. The impact of the timing and type of ASyS remains unclear. METHODS: This multicenter cohort study included data from 9 centers betwee…
View article: Dual mechanism of Anti-Seizure Medications in controlling seizure activity
Dual mechanism of Anti-Seizure Medications in controlling seizure activity Open
Background: Anti-seizure medications (ASMs) can reduce seizure duration, but their precise modes of action are unclear. Specifically, it is unknown whether ASMs shorten seizures by simply compressing existing seizure activity into a shorte…
View article: Quantitative Cortex‐Based Mapping With Hybrid <sup>18</sup>F‐<scp>FDG</scp>‐<scp>PET</scp>/<scp>MR</scp> Images in <scp>MRI</scp>‐Negative Epilepsy
Quantitative Cortex‐Based Mapping With Hybrid <sup>18</sup>F‐<span>FDG</span>‐<span>PET</span>/<span>MR</span> Images in <span>MRI</span>‐Negative Epilepsy Open
Objectives Localization of the network underlying drug‐resistant focal epilepsy in individuals considering surgical treatment with unremarkable MRI is challenging. Concordance rates of 40%–69% have been reported with FDG‐PET image statisti…
View article: Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning
Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning Open
Objectives This study aims to refine computer-assisted planning (CAP) of SEEG implantations by adding spatial constraints from prior SEEG trajectories (“Priors”) to improve safety and reduce manual adjustments, without increasing planning …
View article: Automated generation of epilepsy surgery resection masks; The RAMPS pipeline
Automated generation of epilepsy surgery resection masks; The RAMPS pipeline Open
MRI-based delineation of brain tissue removed by epilepsy surgery can be challenging due to post-operative brain shift. In consequence, most studies use manual approaches which are prohibitively time-consuming for large sample sizes, requi…
View article: Fast Interpretable Greedy-Tree Sums
Fast Interpretable Greedy-Tree Sums Open
Modern machine learning has achieved impressive prediction performance, but often sacrifices interpretability, a critical consideration in high-stakes domains such as medicine. In such settings, practitioners often use highly interpretable…
View article: Associations between epilepsy-related polygenic risk and brain morphology in childhood
Associations between epilepsy-related polygenic risk and brain morphology in childhood Open
A bstract Temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) is associated with a complex genetic architecture, but the translation from genetic risk factors to brain vulnerability remains unclear. Here, we examined associations be…