Explanipedia

Effects of Mucosal Decongestion on Nasal Aerodynamics: A Pilot Study Open

Ahmad T. Hamdan, Giancarlo Bonotto Cherobin, Richard Louis Voegels, John S. Rhee, Guilherme J. M. Garcia · 2024

Objective Mucosal decongestion with nasal sprays is a common treatment for nasal airway obstruction. However, the impact of mucosal decongestion on nasal aerodynamics and the physiological mechanism of nasal airflow sensation are incomplet…

Estimation of Nasal Airway Cross‐sectional Area From Endoscopy Using Depth Maps: A Proof‐of‐Concept Study Open

Guilherme J. M. Garcia, Dominic J. Catalano, Axel Shum, Christopher E. Larkee, John S. Rhee · 2024

Objective Endoscopy is routinely used to diagnose obstructive airway diseases. Currently, endoscopy is only a visualization technique and does not allow quantification of airspace cross‐sectional areas (CSAs). This pilot study tested the h…

Anatomical determinants of upper airway collapsibility in obstructive sleep apnea: A systematic review and meta-analysis Open

Phillip J. Hartfield, Jaroslaw Janczy, Abhay Sharma, Hillary A. Newsome, Rodney Sparapani , et al. · 2022

0738 Clinical and Physiological Relevance of Computational Studies of Obstructive Sleep Apnea: A Systematic Literature Review Open

Phillip Hartfield, Rodney Sparapani, B. Tucker Woodson, John S. Rhee, Guilherme J. M. Garcia · 2022

Introduction Structural interventions for obstructive sleep apnea (OSA) have unpredictable success rates. Anatomically accurate computer simulations of airflow and soft tissue dynamics may be used in future virtual intervention planning to…

Effect of tube length on the buckling pressure of collapsible tubes Open

M. Amin F. Zarandi, Kevin D. Garman, John S. Rhee, B. Tucker Woodson, Guilherme J. M. Garcia · 2021

Objective Measures in Aesthetic and Functional Nasal Surgery: Perspectives on Nasal Form and Function Open

Sachin Pawar, Guilherme J. M. Garcia, Julia S. Kimbell, John S. Rhee · 2021

The outcomes of aesthetic and functional nasal surgery are difficult to assess objectively due to the intricate balance between nasal form and function. Despite historical emphasis on patient-reported subjective measures, objective measure…

Deviated nasal septum hinders intranasal sprays: A computer simulation study Open

Dennis O. Frank‐Ito, Julia S. Kimbell, Daniel T. Cannon, Sachin Pawar, John S. Rhee · 2020

This study investigates how deviated nasal septum affects the quantity and distribution of spray particles, and examines the effects of inspiratory airflow and head position on particle transport.

Effects of Anatomy and Particle Size on Nasal Sprays and Nebulizers Open

Dennis O. Frank‐Ito, Julia S. Kimbell, Sachin Pawar, John S. Rhee · 2020

To study the effects of nasal deformity on aerosol penetration past the nasal valve (NV) for varying particle sizes using sprays or nebulizers.

Clinical consensus statement: Diagnosis and management of nasal valve compromise Open

John S. Rhee, Edward M. Weaver, Stephen S. Park, Shan R. Baker, Peter A. Hilger , et al. · 2020

OBJECTIVE: To create a clinical consensus statement to address ambiguities and disparities in the diagnosis and management of nasal valve compromise (NVC). SUBJECTS AND METHODS: An updated systematic review of the literature was conducted.…

Modeling Nasal Physiology Changes Due to Septal Perforations Open

Daniel E. Cannon, Dennis O. Frank‐Ito, Julia S. Kimbell, David M. Poetker, John S. Rhee · 2020

To use computational fluid dynamics (CFD) technology to help providers understand 1) how septal perforations may alter nasal physiology and 2) how these alterations are influenced by perforation size and location.

Perception of Better Nasal Patency Correlates with Increased Mucosal Cooling after Surgery for Nasal Obstruction Open

Corbin D. Sullivan, Guilherme J. M. Garcia, Dennis O. Frank‐Ito, Julia S. Kimbell, John S. Rhee · 2020

1. Quantify mucosal cooling (i.e., heat loss) spatially in the nasal passages of nasal airway obstruction (NAO) patients before and after surgery using computational fluid dynamics (CFD). 2. Correlate mucosal cooling with patient-reported …

Simulating the Nasal Cycle with Computational Fluid Dynamics Open

Ruchin Patel, Guilherme J. M. Garcia, Dennis O. Frank‐Ito, Julia S. Kimbell, John S. Rhee · 2020

(1) Develop a method to account for the confounding effect of the nasal cycle when comparing pre- and post-surgery objective measures of nasal patency. (2) Illustrate this method by reporting objective measures derived from computational f…

Predicting Postsurgery Nasal Physiology with Computational Modeling: Current Challenges and Limitations Open

Dennis O. Frank‐Ito, Julia S. Kimbell, Purushottam W. Laud, Guilherme J. M. Garcia, John S. Rhee · 2020

High failure rates for surgical treatment of nasal airway obstruction (NAO) indicate that better diagnostic tools are needed to improve surgical planning. This study evaluates whether computer models based on a surgeon’s edits of pre-surge…

A Systematic Review of Patient-Reported Nasal Obstruction Scores: Defining Normative and Symptomatic Ranges in Surgical Patients Open

John S. Rhee, Corbin D. Sullivan, Dennis O. Frank‐Ito, Julia S. Kimbell, Guilherme J. M. Garcia · 2020

A gold standard objective measure of nasal airway obstruction (NAO) does not currently exist, so patient-reported measures are commonly used, particularly the Nasal Obstruction Symptom Evaluation (NOSE) and the visual analog scale (VAS). H…

Computed intranasal spray penetration: comparisons before and after nasal surgery Open

Dennis O. Frank‐Ito, Julia S. Kimbell, Daniel T. Cannon, John S. Rhee · 2020

Quantitative methods for comparing intranasal drug delivery efficiencies pre- and postoperatively have not been fully utilized. The objective of this study is to use computational fluid dynamics techniques to evaluate aqueous nasal spray p…

Toward Personalized Nasal Surgery Using Computational Fluid Dynamics Open

John S. Rhee · 2020

To evaluate whether virtual surgery (VS) performed on 3D nasal airway models can predict post-surgical, biophysical parameters obtained by computational fluid dynamics (CFD).

Role of Virtual Surgery in Preoperative Planning: Assessing the Individual Components of Functional Nasal Airway Surgery Open

John S. Rhee · 2020

There are often multiple anatomic factors that contribute to nasal obstruction, creating difficulty in deciding which components to address for a successful outcome. The purpose of this pilot study is to demonstrate the effect of individua…

Computed nasal resistance compared with patient-reported symptoms in surgically treated nasal airway passages: A preliminary report Open

Julia S. Kimbell, Guilherme J. M. Garcia, Dennis O. Frank‐Ito, Daniel E. Cannon, Sachin S. Pawar , et al. · 2020

Background:Nasal airway obstruction (NAO) is a common health condition impacting mood, energy, recreation, sleep, and overall quality of life. Nasal surgery often addresses NAO but the results are sometimes unsatisfactory. Evaluating surgi…

Narrowed Posterior Nasal Airway Limits Efficacy of Anterior Septoplasty Open

David A. Campbell, Masoud Gh. Moghaddam, John S. Rhee, Guilherme J. M. Garcia · 2020

Background: Predicting symptomatic relief after septoplasty has been difficult. Minimal cross-sectional area (mCSA) measured by acoustic rhinometry and airflow resistance (R) measured by rhinomanometry have been used to selec…

Virtual septoplasty: a method to predict surgical outcomes for patients with nasal airway obstruction Open

Masoud Gh. Moghaddam, Guilherme J. M. Garcia, Dennis O. Frank‐Ito, Julia S. Kimbell, John S. Rhee · 2020

Introducing Facial Plastic Surgery & Aesthetic Medicine: The Best of Both Worlds Open

John S. Rhee · 2020

Normative ranges of nasal airflow variables in healthy adults Open

Azadeh A.T. Borojeni, Guilherme J. M. Garcia, Masoud Gh. Moghaddam, Dennis O. Frank‐Ito, Julia S. Kimbell , et al. · 2019

JAMA Open

Michael Berkwits, Gregory Curfman, Robert Golub, Edward H. Livingston, Jody Zylke , et al. · 2019

A hierarchical stepwise approach to evaluate nasal patency after virtual surgery for nasal airway obstruction Open

Dennis O. Frank‐Ito, Julia S. Kimbell, Azadeh A.T. Borojeni, Guilherme J. M. Garcia, John S. Rhee · 2018

Upper airway reconstruction using long‐range optical coherence tomography: Effects of airway curvature on airflow resistance Open

Julia S. Kimbell, Saikat Basu, Guilherme J. M. Garcia, Dennis O. Frank‐Ito, Frances Lazarow , et al. · 2018

Objectives Adenotonsillectomy (AT) is commonly used to treat upper airway obstruction in children, but selection of patients who will benefit most from AT is challenging. The need for diagnostic evaluation tools without sedation, radiation…

An Interactive, Patient-Specific Virtual Surgical Planning System for Upper Airway Obstruction Treatments Open

Rachel B. Clipp, Jared Vicory, Samantha Horvath, Sorin Mitran, Julia S. Kimbell , et al. · 2018

Upper airway obstructions leading todifficulty breathing are significant problems that often require surgery to improve patient quality of life. However, these surgeries often have poor outcomes with little symptom improvement. This paper …

Oxidative Stress Induces an Interactive Decline in Wnt and Nrf2 Signaling in Degenerating Retinal Pigment Epithelium Open

Katayoon B. Ebrahimi, Marisol Cano, John S. Rhee, Sayantan Datta, Lei Wang , et al. · 2017

Our data offer new insights into how combined modern oxidative stresses of cigarette smoking and HFD contribute to GA through an interactive decline in Wnt and Nrf2 signaling. Antioxid. Redox Signal. 29, 389-407.

JAMA Open

Michael Berkwits, Robert Golub, Ronna Henry, Edward H. Livingston, Jody Zylke , et al. · 2017

Death by Gun Violence—A Public Health Crisis Open

Howard Bauchner, Frederick P. Rivara, Robert O. Bonow, Neil M. Bressler, Mary L. Disis , et al. · 2017

Death by Gun Violence—A Public Health Crisis Open

Howard Bauchner, Frederick P. Rivara, Robert O. Bonow, Neil M. Bressler, Mary L. Disis , et al. · 2017

The shooting in Las Vegas, Nevada, that left 59 people dead, 10 times that number wounded, and thousands of people with the psychological distress from being present at the scene during and after the massacre has once again raised the issu…

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