John S. Schieffelin
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View article: A study protocol for the assessment of antibiotic use and bacterial antimicrobial resistance among children under five years of age: Implications for a resource-limited setting
A study protocol for the assessment of antibiotic use and bacterial antimicrobial resistance among children under five years of age: Implications for a resource-limited setting Open
Background The irrational use of antibiotics to treat infections in children is a crucial contributing factor to bacterial antimicrobial resistance (AMR), which can have economic and health consequences, such as morbidity and mortality. Th…
View article: Altered SARS-CoV-2 Vaccine Responses in People Living with HIV: Roles of ART, HIV-Specific T-Cells, and CD4 Deficiency 9309
Altered SARS-CoV-2 Vaccine Responses in People Living with HIV: Roles of ART, HIV-Specific T-Cells, and CD4 Deficiency 9309 Open
Description This study investigated how human immunodeficiency virus (HIV) and associated immunosuppression influenced development of post-vaccination immunity to SARS-CoV-2. among. Twenty-two people living with HIV (PLWH) and 30 healthy d…
View article: Evaluation of antigen and antibody assays for surveillance of Lassa virus in peri-domestic rodents in southeastern Sierra Leone: a cross-sectional study
Evaluation of antigen and antibody assays for surveillance of Lassa virus in peri-domestic rodents in southeastern Sierra Leone: a cross-sectional study Open
Summary: Background: Lassa fever, caused by Lassa mammarenavirus (LASV), is a rodent-borne disease endemic to west Africa. Zoonotic surveillance of LASV provides epidemiological insights into its potential presence. We aimed to assess LASV…
View article: Respiratory Syncytial Virus Epidemiology and Clinical Characteristics among Young Children Hospitalized in Sierra Leone
Respiratory Syncytial Virus Epidemiology and Clinical Characteristics among Young Children Hospitalized in Sierra Leone Open
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections in children under 5 years of age, resulting in significant morbidity and mortality worldwide. The aim of the current study is to investigate t…
View article: A study protocol for the assessment of antibiotic use and bacterial antimicrobial resistance among children under five years of age: implications for a resource-limited setting
A study protocol for the assessment of antibiotic use and bacterial antimicrobial resistance among children under five years of age: implications for a resource-limited setting Open
Background The irrational use of antibiotics to treat infections in children is a crucial contributing factor to bacterial antimicrobial resistance (AMR), which can have economic and health consequences, such as morbidity and mortality. Th…
View article: Hyperendemicity of Rift Valley Fever in Southwestern Uganda Associated With the Rapidly Evolving Lineage C Viruses
Hyperendemicity of Rift Valley Fever in Southwestern Uganda Associated With the Rapidly Evolving Lineage C Viruses Open
Background Recent Rift Valley fever (RVF) epidemiology in the eastern Africa region is characterized by widening geographic range and increasing frequency of small disease clusters. Here we conducted studies in the southwestern (SW) Uganda…
View article: Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine
Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine Open
The development of a Zika virus (ZIKV) vaccine is complicated by the high homology between ZIKV and dengue virus (DENV) envelope (E) proteins, resulting in immunological cross-reactivity that can exacerbate disease through antibody-depende…
View article: Long-term clinical sequelae among Sudan ebolavirus disease survivors 2 years post-infection: a matched cohort study
Long-term clinical sequelae among Sudan ebolavirus disease survivors 2 years post-infection: a matched cohort study Open
Background The long-term health effects of ebolavirus disease (EVD) caused by the Sudan ebolavirus (SUDV) strain remain poorly characterized. Here, we assessed the nature, frequency, and persistence of post-EVD clinical symptoms among SUDV…
View article: Continuous vital sign monitoring of acute Lassa fever using wearable biosensor devices in West Africa
Continuous vital sign monitoring of acute Lassa fever using wearable biosensor devices in West Africa Open
Background Lassa fever is a fulminant viral illness associated with high in-hospital mortality. This disease constitutes a serious public health concern in West Africa, in particular Nigeria and the Mano River Union region (Guinea, Liberia…
View article: A systematic review of the immuno-inflammatory dysfunction secondary to viral hemorrhagic fevers; Ebola and Lassa fever
A systematic review of the immuno-inflammatory dysfunction secondary to viral hemorrhagic fevers; Ebola and Lassa fever Open
The viral hemorrhagic fevers Ebola and Lassa fever are endemic to Sub-Saharan Africa. Both viruses are characterized by high case fatality risk and lifelong debilitating sequelae including blindness and deafness. However, despite these fin…
View article: Importance of outbreak response research in bridging knowledge gaps on emerging infectious diseases
Importance of outbreak response research in bridging knowledge gaps on emerging infectious diseases Open
An important outcome of the devastating 2014 West African Ebola virus disease outbreak and the 2020 COVID-19 pandemic has been the growing promotion of conducting research during outbreaks of emerging infectious diseases (EIDs) as a valuab…
View article: Understanding the pathogenesis of uveitis in Ebola virus disease survivors: a study protocol for clinical, molecular virologic, and immunologic characterization
Understanding the pathogenesis of uveitis in Ebola virus disease survivors: a study protocol for clinical, molecular virologic, and immunologic characterization Open
The 2013-2016 Western African outbreak of the Ebola virus disease (EVD), the largest recorded outbreak since the discovery of Ebola virus (EBOV) in 1976, destabilized local health systems and left thousands of survivors at risk for post-ac…
View article: Severe long-term clinical sequelae among Sudan ebolavirus disease survivors 2 years post-infection
Severe long-term clinical sequelae among Sudan ebolavirus disease survivors 2 years post-infection Open
View article: 307 Post-Ebola Syndrome Presents with Distinct Clinical Phenotypes in Pediatric Ebolavirus Disease Survivors: What Are the Drivers?
307 Post-Ebola Syndrome Presents with Distinct Clinical Phenotypes in Pediatric Ebolavirus Disease Survivors: What Are the Drivers? Open
Objectives/Goals: Despite the acknowledgment of post-Ebola syndrome (PES), young EVD survivors have received little attention. The mechanistic drivers and long-term consequences of PES and EVD early in life are unknown. We aim to define PE…
View article: Characterizing Musculoskeletal Sequelae in Ebola Virus Survivors During the 7 Years Since Hospital Discharge in Eastern Sierra Leone
Characterizing Musculoskeletal Sequelae in Ebola Virus Survivors During the 7 Years Since Hospital Discharge in Eastern Sierra Leone Open
Ebola virus disease survivors demonstrated musculoskeletal sequelae during the 7 years since hospital discharge. Reported joint pain and joint tenderness to palpation were the most common sequelae. Sequelae generally decreased over time, b…
View article: Stressors and coping strategies among people affected by Ebola Virus Disease (EVD) in West Africa: A qualitative study across multiple levels of the social ecology
Stressors and coping strategies among people affected by Ebola Virus Disease (EVD) in West Africa: A qualitative study across multiple levels of the social ecology Open
The 2014-16 Ebola Virus Disease (EVD) epidemic in West Africa is the most fatal on record and resulted in significant psychosocial and economic implications for those affected. Coping strategies and social supports can abate the effects of…
View article: Atypical hyperendemicity of Rift Valley fever in Southwestern Uganda associated with the rapidly evolving lineage C viruses
Atypical hyperendemicity of Rift Valley fever in Southwestern Uganda associated with the rapidly evolving lineage C viruses Open
Introduction Recent Rift Valley fever (RVF) epidemiology in eastern Africa region is characterized by widening geographic range and increasing frequency of small disease clusters. Here we conducted studies in southwestern (SW) Uganda regio…
View article: Correction: A prospective, multi-site, cohort study to estimate incidence of infection and disease due to Lassa fever virus in West African countries (the Enable Lassa research programme)–Study protocol
Correction: A prospective, multi-site, cohort study to estimate incidence of infection and disease due to Lassa fever virus in West African countries (the Enable Lassa research programme)–Study protocol Open
[This corrects the article DOI: 10.1371/journal.pone.0283643.].
View article: Systematic Review and Meta-Analysis of Female Reproductive Health Following Ebola Virus Disease
Systematic Review and Meta-Analysis of Female Reproductive Health Following Ebola Virus Disease Open
The viral hemorrhagic fevers Lassa fever (LF) and Ebola virus disease (EVD) have been documented to cause long-term health problems in survivors. Limited studies have noted the presence of adverse reproductive health outcomes, including me…
View article: Post‐COVID immunity in patients with solid tumor or hematological malignancies treated with SARS‐CoV‐2 monoclonal antibodies
Post‐COVID immunity in patients with solid tumor or hematological malignancies treated with SARS‐CoV‐2 monoclonal antibodies Open
Purpose SARS‐CoV‐2 monoclonal antibody (mAB) therapy has effectively treated severe COVID‐19, although how this contributes to protective antiviral immunity in settings of malignancy is poorly defined. Patients and Methods We evaluated the…
View article: Long-term visual outcomes and histopathologic findings after cataract surgery in Ebola virus disease survivors in the Ebola virus RNA persistence in ocular tissues and fluids (EVICT) study
Long-term visual outcomes and histopathologic findings after cataract surgery in Ebola virus disease survivors in the Ebola virus RNA persistence in ocular tissues and fluids (EVICT) study Open
Background/Objectives Ebola virus disease (EVD) survivors develop post-acute ophthalmic sequelae, including a high prevalence of uveitis that may be complicated by vision-threatening cataract. After the non-detection of Ebola virus (EBOV) …
View article: Assessment of sociodemographic factors associated with time to self-reported COVID-19 infection among a large multi-center prospective cohort population in the southeastern United States
Assessment of sociodemographic factors associated with time to self-reported COVID-19 infection among a large multi-center prospective cohort population in the southeastern United States Open
Objective We aimed to investigate sociodemographic factors associated with self-reported COVID-19 infection. Methods The study population was a prospective multicenter cohort of adult volunteers recruited from healthcare systems located in…
View article: Continuous vital sign monitoring of individuals with acute Lassa fever using wearable biosensor devices
Continuous vital sign monitoring of individuals with acute Lassa fever using wearable biosensor devices Open
Background Lassa fever is a fulminant viral illness associated with high in-hospital mortality. This disease constitutes a serious public health concern in West Africa, in particular Nigeria and the Mano River Union region (Guinea, Liberia…
View article: Ebola Virus–Specific Neutralizing Antibody Persists at High Levels in Survivors 2 Years After Resolution of Disease in a Sierra Leonean Cohort
Ebola Virus–Specific Neutralizing Antibody Persists at High Levels in Survivors 2 Years After Resolution of Disease in a Sierra Leonean Cohort Open
Ebola virus (EBOV) infection results in Ebola virus disease (EVD), an often severe disease with a nonspecific presentation. Since its recognition, periodic outbreaks of EVD continue to occur in sub-Saharan Africa. The 2013-2016 West Africa…
View article: Ebola Virus–Specific Neutralizing Antibody Persists at High Levels in Survivors 2 Years After Resolution of Disease in a Sierra Leonean Cohort
Ebola Virus–Specific Neutralizing Antibody Persists at High Levels in Survivors 2 Years After Resolution of Disease in a Sierra Leonean Cohort Open
Ebola virus (EBOV) infection results in Ebola virus disease (EVD), an often severe disease with a nonspecific presentation. Since its recognition, periodic outbreaks of EVD continue to occur in sub-Saharan Africa. The 2013–2016 West Africa…
View article: 344 Understanding drivers of post-Ebola syndrome (PES) in pediatric survivors of Ebolavirus disease: characterization and the way forward.
344 Understanding drivers of post-Ebola syndrome (PES) in pediatric survivors of Ebolavirus disease: characterization and the way forward. Open
OBJECTIVES/GOALS: Ebolavirus disease survivors report persistent, debilitating health concerns dubbed Post-Ebola Syndrome (PES). Attention to PES in young survivors is lacking, we describe PES in pediatric EVD survivors in Eastern Sierra L…
View article: Altered COVID-19 immunity in children with asthma by atopic status
Altered COVID-19 immunity in children with asthma by atopic status Open
View article: Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever
Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever Open
View article: Cardiopulmonary dysfunction among survivors of the 2014 West African Ebola outbreak
Cardiopulmonary dysfunction among survivors of the 2014 West African Ebola outbreak Open
View article: Understanding drivers of post-Ebola syndrome (PES) in pediatric survivors of Ebolavirus disease: characterization and the way forward
Understanding drivers of post-Ebola syndrome (PES) in pediatric survivors of Ebolavirus disease: characterization and the way forward Open