John Snedeker
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View article: Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants
Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants Open
The primary cilium is a signaling center critical for proper embryonic development. Previous studies have demonstrated that mice lacking Ttc21b have impaired retrograde trafficking within the cilium and multiple organogenesis phenotypes, i…
View article: A tissue-specific role for intraflagellar transport genes during craniofacial development
A tissue-specific role for intraflagellar transport genes during craniofacial development Open
Primary cilia are nearly ubiquitous, cellular projections that function to transduce molecular signals during development. Loss of functional primary cilia has a particularly profound effect on the developing craniofacial complex, causing …
View article: Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development
Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development Open
Primary cilia are organelles extended from virtually all cells and are required for the proper regulation of a number of canonical developmental pathways. The role in cortical development of proteins important for ciliary form and function…