Samantha E. John
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View article: Network analysis of neuropsychiatric symptoms in behavioral variant frontotemporal dementia
Network analysis of neuropsychiatric symptoms in behavioral variant frontotemporal dementia Open
Background Behavioral variant frontotemporal dementia (bvFTD) is characterized by neuropsychiatric symptoms (NPS) and personality changes that lead to functional decline and caregiver distress. There are currently no FDA‐approved pharmacot…
View article: Education, Sex, and Age Shape Rey Complex Figure Performance in Cognitively Normal Adults: An Interpretable Machine Learning Study
Education, Sex, and Age Shape Rey Complex Figure Performance in Cognitively Normal Adults: An Interpretable Machine Learning Study Open
Background: Demographic factors such as education, sex, and age can significantly influence cognitive test performance, yet their impact on the Montreal Cognitive Assessment (MoCA) and Rey Complex Figure (CF) test has not been fully charac…
View article: Classification of AD and bvFTD using neuropsychological and neuropsychiatric variables: a machine learning study
Classification of AD and bvFTD using neuropsychological and neuropsychiatric variables: a machine learning study Open
INTRODUCTION Machine learning (ML) is increasingly used for clinical classification of Alzheimer's disease (AD) and related dementias. Prior studies identified useful diagnostic features for AD and behavioral variant frontotemporal dementi…
View article: Comparing clinical features of behavioral variant frontotemporal dementia and Alzheimer's disease using network analysis
Comparing clinical features of behavioral variant frontotemporal dementia and Alzheimer's disease using network analysis Open
INTRODUCTION Clinical characterization of behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) is challenging due to overlapping neuropsychiatric symptoms and cognitive profiles between the two conditions. METHOD…
View article: Neuropsychiatric symptoms predict rate of change in executive function in Alzheimer’s disease and related dementias
Neuropsychiatric symptoms predict rate of change in executive function in Alzheimer’s disease and related dementias Open
Objective: Neuropsychiatric symptoms (NPS) are considered diagnostic and prognostic indicators of dementia and are attributable to neurodegenerative processes. Little is known about the prognostic value of early NPS on executive functionin…
View article: SELF-EFFICACY PARTIALLY MEDIATES PHYSICAL FUNCTIONING AND QUALITY OF LIFE IN MIDDLE-AGED ADULTS WITH DISABILITY
SELF-EFFICACY PARTIALLY MEDIATES PHYSICAL FUNCTIONING AND QUALITY OF LIFE IN MIDDLE-AGED ADULTS WITH DISABILITY Open
Middle-age is understudied. Adults living with long-term physical disability (LTPD) face added health conditions during middle-age, heightening psychosocial stress. The role of self-efficacy in managing these conditions and their impact on…
View article: Blood‐based biomarkers for Alzheimer’s disease among ethnoracial minority samples – a scoping review
Blood‐based biomarkers for Alzheimer’s disease among ethnoracial minority samples – a scoping review Open
Background Approximately 6.7 million Americans, aged 65 and older, are living with Alzheimer’s disease (AD) dementia. Ethnoracial minority populations are at greater risk for AD. Black/African Americans (B/AA) are twice as likely than non‐…
View article: Clinical importance in Alzheimer’s disease: effects of anchor agreement and disease severity
Clinical importance in Alzheimer’s disease: effects of anchor agreement and disease severity Open
Objectives Methods of evaluating clinically meaningful decline are critical in research on Alzheimer’s disease. A common method of quantifying clinically meaningful change is to calculate an anchor-based minimal clinically important differ…
View article: Blood‐based biomarker profiles of community cohort of rural‐dwelling older adults
Blood‐based biomarker profiles of community cohort of rural‐dwelling older adults Open
Background Geography may influence Alzheimer’s disease risk, but there have been few prospective studies with biomarker characterization among rural‐dwelling individuals. We present preliminary biomarker data from the rural cohort followed…
View article: Challenges and Opportunities in a Resource Desert: Las Vegas Boot Camp Translation
Challenges and Opportunities in a Resource Desert: Las Vegas Boot Camp Translation Open
Background The state of Nevada has the 3 rd fastest growing rate of Alzheimer’s disease and related dementias (ADRD) in the country with a 30.6% projected increase between 2020 and 2025. Growth in ADRD is complemented by growth in the dive…
View article: 1 Clinically Meaningful Change in Alzheimer’s Disease Depends on Anchor Agreement and Disease Severity
1 Clinically Meaningful Change in Alzheimer’s Disease Depends on Anchor Agreement and Disease Severity Open
Objective: Measures of clinical significance are critical for meaningful interpretation of treatment outcome research on Alzheimer’s disease. A common method of quantifying clinical significance is to calculate a minimal clinically importa…
View article: 97 Exploring Urban-Rural Disparities in Alzheimer’s disease: Clinical characterization of a southern Nevada cohort
97 Exploring Urban-Rural Disparities in Alzheimer’s disease: Clinical characterization of a southern Nevada cohort Open
Objective: As the US population ages, the prevalence of Alzheimer’s disease and related dementias (AD/RD) is on the rise. This is especially true in rural America, where mortality rates due to AD/RD are rising faster than in metropolitan a…
View article: 3 Network Analysis of Neuropsychiatric Symptoms in Alzheimer’s Disease
3 Network Analysis of Neuropsychiatric Symptoms in Alzheimer’s Disease Open
Objective: Neuropsychiatric symptoms due to Alzheimer’s disease (AD) and mild cognitive impairment (MCI) can decrease quality of life for patients and increase caregiver burden. Better characterization of neuropsychiatric symptoms is neede…
View article: 3 Ethnoracial Differences in Anchor Agreement and MCID Estimation in Alzheimer’s Disease
3 Ethnoracial Differences in Anchor Agreement and MCID Estimation in Alzheimer’s Disease Open
Objective: Alzheimer’s disease (AD) clinical trials lack diverse representation, limiting their generalizability. In addition, the clinical meaningfulness of observed changes during treatment may vary as a function of participant character…
View article: Cognitive aging in rural communities: preliminary memory characterization of a community cohort from Southern Nevada
Cognitive aging in rural communities: preliminary memory characterization of a community cohort from Southern Nevada Open
Introduction Rural-dwelling older adults face unique health challenges that may increase risk for Alzheimer's disease and dementia but are underrepresented in aging research. Here, we present an initial characterization of a rural communit…
Network analysis of neuropsychiatric symptoms in Alzheimer’s disease Open
Background Neuropsychiatric symptoms due to Alzheimer’s disease (AD) and mild cognitive impairment (MCI) can decrease quality of life for patients and increase caregiver burden. Better characterization of neuropsychiatric symptoms and meth…
View article: Global rural health disparities in Alzheimer's disease and related dementias: State of the science
Global rural health disparities in Alzheimer's disease and related dementias: State of the science Open
INTRODUCTION Individuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place‐based health disparities. Identifying multiple potentially modifiable …
View article: Network Analysis of Neuropsychiatric Symptoms in Alzheimer’s Disease
Network Analysis of Neuropsychiatric Symptoms in Alzheimer’s Disease Open
Background: Neuropsychiatric symptoms due to Alzheimer’s disease (AD) and mild cognitive impairment (MCI) can decrease quality of life for patients and increase caregiver burden. Better characterization of neuropsychiatric symptoms and met…
View article: A boot camp translation of Alzheimer's disease in Hispanic/Latino communities
A boot camp translation of Alzheimer's disease in Hispanic/Latino communities Open
Introduction Hispanics/Latinos (H/Ls) are significantly underrepresented in Alzheimer's disease (AD) research participant samples. This exclusion limits our interpretation of research findings and understanding of the causes of brain healt…
View article: Urbanicity and cognitive functioning in later life
Urbanicity and cognitive functioning in later life Open
Introduction Prior research has shown disparities in cognitive functioning across the rural–urban continuum. We examine individual‐ and contextual‐level factors to understand how and why urbanicity shapes cognitive functioning across older…
View article: Changes in ImPACT Cognitive Subtest Networks Following Sport-Related Concussion
Changes in ImPACT Cognitive Subtest Networks Following Sport-Related Concussion Open
Objective: High school athletes are administered ImPACT at the start of the academic year or sport season and again after suspected concussion. Concussion management involves the comparison of baseline and post-injury cognitive scores with…
View article: UTILIZING BOOT CAMP TRANSLATION TO ENCOURAGE HISPANIC/LATINX PARTICIPATION IN ALZHEIMER’S RESEARCH
UTILIZING BOOT CAMP TRANSLATION TO ENCOURAGE HISPANIC/LATINX PARTICIPATION IN ALZHEIMER’S RESEARCH Open
Hispanic/Latinx (H/L) individuals are 50% more likely to develop Alzheimer’s disease (AD), relative to non-Hispanic whites. Despite higher prevalence rates and earlier age of onset, H/L individuals are underrepresented in aging and AD rese…
View article: Frontal Metabolites and Alzheimer’s Disease Biomarkers in Healthy Older Women and Women Diagnosed with Mild Cognitive Impairment
Frontal Metabolites and Alzheimer’s Disease Biomarkers in Healthy Older Women and Women Diagnosed with Mild Cognitive Impairment Open
Background: Women account for two thirds of the prevalence and incidence of Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Evidence suggest that sex may differently influence the expression of proteins amyloid-beta (Aβ 1–42 …
View article: A Novel Way of Measuring Dual-Task Interference: The Reliability and Construct Validity of the Dual-Task Effect Battery in Neurodegenerative Disease
A Novel Way of Measuring Dual-Task Interference: The Reliability and Construct Validity of the Dual-Task Effect Battery in Neurodegenerative Disease Open
Background. Decreased automaticity is common among individuals with neurodegenerative disease and is often assessed using dual-task (DT) paradigms. However, the best methods for assessing performance changes related to DT demands remain in…
View article: The roles of executive functioning, simple attention, and medial temporal lobes in early learning, late learning, and delayed recall
The roles of executive functioning, simple attention, and medial temporal lobes in early learning, late learning, and delayed recall Open
Fractionating performance of a verbal list-learning test can provide a nuanced interpretation of the relationship between brain networks and learning and memory abilities. Within older adult samples, including those with mild cognitive imp…
View article: Nevada exploratory Alzheimer’s disease research center: Advancing dementia care in rural communities
Nevada exploratory Alzheimer’s disease research center: Advancing dementia care in rural communities Open
Background People with MCI and AD living in rural areas represent an understudied and underserved population in the broader AD landscape. Very little works have been done on rural cohorts by NIA‐designated Alzheimer’s Disease Research Cent…
View article: Examination of the reliability and feasibility of two smartphone applications to assess executive functioning in racially diverse older adults
Examination of the reliability and feasibility of two smartphone applications to assess executive functioning in racially diverse older adults Open
Inclusion of Black participants in clinical research is a national priority. Mobile applications and remote data collection may increase study access for diverse populations. This study examined the reliability and feasibility of two mobil…