John Stradling
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View article: The effect of supplemental oxygen and continuous positive airway pressure withdrawal on endocan levels
The effect of supplemental oxygen and continuous positive airway pressure withdrawal on endocan levels Open
View article: Mild obstructive sleep apnoea in females:<i>post hoc</i>analysis of the MERGE randomised controlled trial
Mild obstructive sleep apnoea in females:<i>post hoc</i>analysis of the MERGE randomised controlled trial Open
Background A post hoc analysis of the MERGE trial was conducted, to investigate whether sex differences are evident at the mildest end of the disease spectrum, for symptoms associated with obstructive sleep apnoea (OSA) and the response to…
View article: Right ventricular responses to CPAP therapy in obstructive sleep apnea: CMR analysis of the MOSAIC randomized trial
Right ventricular responses to CPAP therapy in obstructive sleep apnea: CMR analysis of the MOSAIC randomized trial Open
Effects of continuous positive airway pressure (CPAP) on right ventricular (RV) function in patients with untreated mild‐to‐moderate obstructive sleep apnea (OSA) are unclear. In this exploratory analysis of cardiac magnetic resonance (CMR…
View article: Effect of CPAP therapy on blood pressure in patients with OSA: a worldwide individual patient data meta-analysis
Effect of CPAP therapy on blood pressure in patients with OSA: a worldwide individual patient data meta-analysis Open
Background Obstructive sleep apnoea (OSA) is a well-known cardiovascular risk factor and is frequently associated with hypertension. The treatment of OSA with continuous positive airway pressure (CPAP) can resolve apnoeas, hypoxia, and sym…
View article: Association between Patient- and Partner-Reported Sleepiness Using the Epworth Sleepiness Scale in Patients with Obstructive Sleep Apnoea
Association between Patient- and Partner-Reported Sleepiness Using the Epworth Sleepiness Scale in Patients with Obstructive Sleep Apnoea Open
Excessive daytime sleepiness in obstructive sleep apnoea (OSA) is often measured differently by patients and their partners. This study investigated the association between patient- and partner-completed Epworth Sleepiness Scale (ESS) scor…
View article: 0788 The effect of CPAP on quality of life in females with mild OSA: Post hoc analysis from the MERGE Randomised Trial
0788 The effect of CPAP on quality of life in females with mild OSA: Post hoc analysis from the MERGE Randomised Trial Open
Introduction The MERGE trial was a multi-centre, randomised, parallel study that showed the beneficial effect of continuous positive airway pressure (CPAP) on quality-of-life in patients with mild obstructive sleep apnea (OSA) (Wimms et al…
View article: Effect of obstructive sleep apnoea on retinal microvascular function: a randomised controlled trial
Effect of obstructive sleep apnoea on retinal microvascular function: a randomised controlled trial Open
View article: Nasal Symptoms in Patients with Obstructive Sleep Apnoea and Their Association with Continuous Positive Airway Pressure Usage
Nasal Symptoms in Patients with Obstructive Sleep Apnoea and Their Association with Continuous Positive Airway Pressure Usage Open
The role of nasal symptoms in continuous positive airway pressure (CPAP) tolerance is not completely clear. This study aimed to investigate the association between CPAP usage and nasal symptoms, either prior to, or developing during, CPAP …
View article: BAY 2253651 for the treatment of obstructive sleep apnoea: a multicentre, double-blind, randomised controlled trial (SANDMAN)
BAY 2253651 for the treatment of obstructive sleep apnoea: a multicentre, double-blind, randomised controlled trial (SANDMAN) Open
BAY 2253651 is a nasally applied genioglossus muscle activator via pharyngeal mucosal receptor stimulation (potassium channel blocker) aimed to treat obstructive sleep apnoea. Although well-tolerated and safe, there was no significant ther…
View article: Period-to-Period Variability of Moderate/Severe Obstructive Sleep Apnoea
Period-to-Period Variability of Moderate/Severe Obstructive Sleep Apnoea Open
View article: Assessing the impact on pharmacists’ time by introducing a technician screening process for clinical trial prescriptions
Assessing the impact on pharmacists’ time by introducing a technician screening process for clinical trial prescriptions Open
Introduction Various national guidance from the Lord Carter 2016 report to the NHS Long term plan have emphasised the need to transform traditional hospital pharmacy and make work streams more efficient.[1] A clinical trials pharmacist has…
View article: Markers of adipose tissue hypoxia are elevated in subcutaneous adipose tissue of severely obese patients with obesity hypoventilation syndrome but not in the moderately obese
Markers of adipose tissue hypoxia are elevated in subcutaneous adipose tissue of severely obese patients with obesity hypoventilation syndrome but not in the moderately obese Open
View article: Obstructive sleep apnoea and the progression of thoracic aortic aneurysm: a prospective cohort study
Obstructive sleep apnoea and the progression of thoracic aortic aneurysm: a prospective cohort study Open
Background Obstructive sleep apnoea (OSA) is associated with an increased prevalence of aortic aneurysms and it has also been suggested that severe OSA furthers aneurysm expansion in the abdomen. We evaluated whether OSA is a risk factor f…
View article: Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial
Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial Open
The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Car…
View article: Effects of suboptimal adherence of CPAP therapy on symptoms of obstructive sleep apnoea: a randomised, double-blind, controlled trial
Effects of suboptimal adherence of CPAP therapy on symptoms of obstructive sleep apnoea: a randomised, double-blind, controlled trial Open
Introduction Continuous positive airway pressure (CPAP) is currently the treatment of choice for sleepiness in patients with obstructive sleep apnoea (OSA); however, adherence is often thought to be suboptimal. We investigated the effects …
View article: Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial
Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial Open
View article: Transcriptomics Identify a Unique Intermittent Hypoxia-mediated Profile in Obstructive Sleep Apnea
Transcriptomics Identify a Unique Intermittent Hypoxia-mediated Profile in Obstructive Sleep Apnea Open
View article: Return of sleep apnoea and sleep fragmentation following CPAP withdrawal in patients with obstructive sleep apnoea
Return of sleep apnoea and sleep fragmentation following CPAP withdrawal in patients with obstructive sleep apnoea Open
We previously published data in the European Respiratory Journal describing the return of obstructive sleep apnoea (OSA) following the withdrawal of continuous positive airway pressure (CPAP) [1]. In this study, about one third of patients…
View article: Effects of Suboptimal Adherence of CPAP-Therapy on Symptoms of Obstructive Sleep Apnea: A Randomized, Double-Blind, Controlled Trial
Effects of Suboptimal Adherence of CPAP-Therapy on Symptoms of Obstructive Sleep Apnea: A Randomized, Double-Blind, Controlled Trial Open
View article: Effects of short-term continuous positive airway pressure withdrawal on cerebral vascular reactivity measured by blood oxygen level-dependent magnetic resonance imaging in obstructive sleep apnoea: a randomised controlled trial
Effects of short-term continuous positive airway pressure withdrawal on cerebral vascular reactivity measured by blood oxygen level-dependent magnetic resonance imaging in obstructive sleep apnoea: a randomised controlled trial Open
Impaired cerebral vascular reactivity (CVR) increases long-term stroke risk. Obstructive sleep apnoea (OSA) is associated with peripheral vascular dysfunction and vascular events. The aim of this trial was to evaluate the effect of continu…
View article: Continuous positive airway pressure effect on visual acuity in patients with type 2 diabetes and obstructive sleep apnoea: a multicentre randomised controlled trial
Continuous positive airway pressure effect on visual acuity in patients with type 2 diabetes and obstructive sleep apnoea: a multicentre randomised controlled trial Open
We sought to establish whether continuous positive airway pressure (CPAP) for obstructive sleep apnoea (OSA) in people with type 2 diabetes and diabetic macular oedema (DMO) improved visual acuity. We randomly assigned 131 eligible patient…
View article: Minimum important difference of the Epworth Sleepiness Scale in obstructive sleep apnoea: estimation from three randomised controlled trials
Minimum important difference of the Epworth Sleepiness Scale in obstructive sleep apnoea: estimation from three randomised controlled trials Open
Background The Epworth Sleepiness Scale (ESS) is a widely used tool for assessing sleepiness in patients with obstructive sleep apnoea (OSA). We aimed to estimate the minimal important difference (MID) in patients with OSA. Methods We used…
View article: Understanding effects of obstructive sleep apnoea and its treatment on the brain and autonomic regulation needs further research
Understanding effects of obstructive sleep apnoea and its treatment on the brain and autonomic regulation needs further research Open
Comment on Reperfusion injury to ischemic medullary brain nuclei after stopping continuous positive airway pressure-induced CO2-reduced vasoconstriction in sleep apnea. [J Thorac Dis. 2018]
View article: Effect of continuous positive airway pressure therapy on circadian patterns of cardiac repolarization in patients with obstructive sleep apnoea: data from a randomized trial
Effect of continuous positive airway pressure therapy on circadian patterns of cardiac repolarization in patients with obstructive sleep apnoea: data from a randomized trial Open
In this exploratory study, CPAP treatment led to an overall reduction in the QTc-interval compared with subtherapeutic CPAP. This reduction seems more pronounced during evening hours and in patients with a QTc above 430 ms.
View article: Nocturnal cerebral hypoxia in obstructive sleep apnoea: a randomised controlled trial
Nocturnal cerebral hypoxia in obstructive sleep apnoea: a randomised controlled trial Open
Cerebral hypoxia may promote cerebral damage in patients with obstructive sleep apnoea (OSA). We investigated whether OSA patients experience nocturnal cerebral hypoxia that is prevented by continuous positive airway pressure (CPAP). OSA p…
View article: Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea—an opportunity for an efficient experimental model
Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea—an opportunity for an efficient experimental model Open
Randomised controlled trials (RCTs) of continuous positive airway pressure (CPAP) in obstructive sleep apnoea (OSA) are time consuming, and their findings often inconclusive or limited due to suboptimal CPAP adherence in CPAP-naïve patient…
View article: Can postural OSA be usefully identified from its severity alone
Can postural OSA be usefully identified from its severity alone Open
Introduction When obstructive sleep apnoea (OSA) does not occur throughout sleep, there must be factors influencing its presence or absence. These are most likely to be sleep stage, posture, and pre-sleep alcohol, amongst others. We hypoth…
View article: Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients
Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients Open
In very obese individuals, our results indicate that increased volumes of upper airway structures are associated with increased severity of OSA, as previously reported in less obese individuals. Increasingly large upper airway structures t…
View article: Can postural OSA be usefully identified from its severity alone?
Can postural OSA be usefully identified from its severity alone? Open
Introduction When obstructive sleep apnoea (OSA) does not occur throughout sleep, there must be factors influencing its presence or absence. These are most likely to be sleep stage, posture and presleep alcohol, among others. We hypothesis…
View article: Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation
Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation Open
clinicaltrials.gov Identifier: NCT00990132.