John B. Sunwoo
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View article: LabOS: The AI-XR Co-Scientist That Sees and Works With Humans
LabOS: The AI-XR Co-Scientist That Sees and Works With Humans Open
Modern science advances fastest when thought meets action. LabOS represents the first AI co-scientist that unites computational reasoning with physical experimentation through multimodal perception, self-evolving agents, and XR-enabled, em…
View article: Supplemental Tables from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Tables from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
Supplemental Table 1 shows patients distribution in OC cohorts from Stanford University. Supplemental Table 2 shows primers for mutagenesis. Supplemental Table 3 shows primers for real-time PCR. Supplemental Table 4 shows gene mutations id…
View article: Supplemental Figure 6 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Figure 6 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
CB-839 overcomes RT resistance in Nrf2E79Q MOC1 cells through regulating the tumor microenvironment.
View article: Supplementary Data 4 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Supplementary Data 4 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma Open
raw cell counts from organoid staining
View article: Supplementary Data 3 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Supplementary Data 3 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma Open
Western_imageJ data
View article: Supplemental Figure 4 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Figure 4 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
NFE2L2 mutation leads to extrinsic radiation resistance.
View article: Supplementary Table 1 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Supplementary Table 1 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma Open
Antibodies used
View article: Supplemental Figure 3 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Figure 3 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
Somatic mutation of NFE2L2 leads to Nrf2 activation and promotes intrinsic radiation resistance in human head and neck squamous cell carcinoma (HNSCC).
View article: Supplementary Data 2 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Supplementary Data 2 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma Open
Western blots
View article: Supplemental Figure 5 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
Supplemental Figure 5 from <i>NFE2L2</i> Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells Open
Nrf2 mutation leads to extrinsic radiation resistance through recruitment of PMN-MDSC in tumors.
View article: 585 DENALI-1: a seamless phase 1/2 study of A2B395, a logic-gated, allogeneic, Tmod CAR T therapy, in patients with EGFR-expressing solid tumors with human leukocyte antigen-A*02 loss of heterozygosity
585 DENALI-1: a seamless phase 1/2 study of A2B395, a logic-gated, allogeneic, Tmod CAR T therapy, in patients with EGFR-expressing solid tumors with human leukocyte antigen-A*02 loss of heterozygosity Open
View article: LabOS: The AI-XR Co-Scientist That Sees and Works With Humans
LabOS: The AI-XR Co-Scientist That Sees and Works With Humans Open
Modern science advances fastest when thought meets action. LabOS represents the first AI co-scientist that unites computational reasoning with physical experimentation through multimodal perception, self-evolving agents, and XR-enabled, em…
View article: Mitochondrial Imaging Detects Early Cardiac Responses to Cancer Immunotherapy
Mitochondrial Imaging Detects Early Cardiac Responses to Cancer Immunotherapy Open
Advances in cancer therapy have improved survival but introduced substantial cardiac risk. Mitochondrial dysfunction underlies cardiotoxicity from conventional therapy, while T cell infiltration drives immunotherapy-related myocarditis. Ea…
View article: LabOS: The AI-XR Co-Scientist That Sees and Works With Humans
LabOS: The AI-XR Co-Scientist That Sees and Works With Humans Open
Modern science advances fastest when thought meets action. LabOS represents the first AI co-scientist that unites computational reasoning with physical experimentation through multimodal perception, self-evolving agents, and Extended-Reali…
View article: Correction: Validation of the Melanoma Institute of Australia’s Sentinel Lymph Node Biopsy Risk Prediction Tool for Cutaneous Melanoma
Correction: Validation of the Melanoma Institute of Australia’s Sentinel Lymph Node Biopsy Risk Prediction Tool for Cutaneous Melanoma Open
View article: Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing
Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing Open
Natural killer (NK) cell-based immunotherapies represent a promising avenue for cancer treatment due to their ability to eliminate cancer cells independently of antigen presentation and potential for “off-the-shelf” use. However, the molec…
View article: VISTA immune checkpoint blunts radiotherapy-induced antitumor immune response
VISTA immune checkpoint blunts radiotherapy-induced antitumor immune response Open
Radiotherapy (RT) is a key treatment for solid neoplasms like head and neck cancer (HNC), but it can also activate and recruit immunosuppressive myeloid cells, causing treatment failure. In this study, we examine the role of V-domain immun…
View article: MONTAGE: A Computation Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities
MONTAGE: A Computation Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities Open
Single-cell spatial-omics has advanced our understanding of how tumor microenvironment contributes to cancer progression. However, most single-cell spatial-omics studies focus on cell types and neighborhoods, offering limited information a…
View article: An intraepithelial ILC1-like natural killer cell subset produces IL-13
An intraepithelial ILC1-like natural killer cell subset produces IL-13 Open
Natural killer (NK) cells are innate immune effectors with considerable heterogeneity and potent antitumor capabilities. Intraepithelial ILC1 (ieILC1)-like NK cells, a population of cytotoxic tissue-resident innate lymphoid cells, have rec…
View article: Correction: Evaluating migration and cytotoxicity of tissue-resident and conventional NK cells in a 3D microphysiological system using live-cell imaging
Correction: Evaluating migration and cytotoxicity of tissue-resident and conventional NK cells in a 3D microphysiological system using live-cell imaging Open
Correction for ‘Evaluating migration and cytotoxicity of tissue-resident and conventional NK cells in a 3D microphysiological system using live-cell imaging’ by Hyeri Choi et al. , Lab Chip , 2025, 25 , 2696–2707, https://doi.org/10.1039/D…
View article: 389 Ex vivo expanded ieILC1-like NK cells induce significant tumor cell death and demonstrate metabolic flexibility and macrophage reprogramming capacity under hypoxic conditions
389 Ex vivo expanded ieILC1-like NK cells induce significant tumor cell death and demonstrate metabolic flexibility and macrophage reprogramming capacity under hypoxic conditions Open
View article: Neoadjuvant Atezolizumab in Patients With Surgically Resectable Advanced Cutaneous Squamous Cell Carcinoma
Neoadjuvant Atezolizumab in Patients With Surgically Resectable Advanced Cutaneous Squamous Cell Carcinoma Open
PURPOSE To evaluate the feasibility of administering three doses of neoadjuvant atezolizumab before curative surgical resection in patients with advanced cutaneous squamous cell carcinoma (cSCC). PATIENTS AND METHODS This single-arm phase …
View article: Using heart rate variability to predict neurological outcomes in preterm infants: a scoping review
Using heart rate variability to predict neurological outcomes in preterm infants: a scoping review Open
View article: Development of Melanoma and Other Nonkeratinocyte Skin Cancers After Thyroid Cancer Radiation
Development of Melanoma and Other Nonkeratinocyte Skin Cancers After Thyroid Cancer Radiation Open
This cohort study evaluates the association between thyroid malignant neoplasms and melanoma and other nonkeratinocyte skin cancers.
View article: Supplementary Figures from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Supplementary Figures from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma Open
Supplemental figures
View article: Supplementary Table 1 from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Supplementary Table 1 from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma Open
Antibodies used
View article: Supplementary Table 1 from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Supplementary Table 1 from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma Open
Antibodies used
View article: Supplementary Figures from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Supplementary Figures from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma Open
Supplemental figures
View article: Supplementary Data 4 from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Supplementary Data 4 from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma Open
raw cell counts from organoid staining
View article: Supplementary Table 2 from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Supplementary Table 2 from Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma Open
Sequences