John T. Lucas
YOU?
Author Swipe
View article: Peer Review of “Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study”
Peer Review of “Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study” Open
View article: 32 | METABOLIC‐ONLY RESPONSE ASSESSMENT ALLOWS RADIATION OMISSION FOR MAJORITY WITH CLASSICAL HODGKIN LYMPHOMA AND MAINTAINS EXCELLENT OUTCOMES: A PHC PHASE 2 STUDY cHOD17
32 | METABOLIC‐ONLY RESPONSE ASSESSMENT ALLOWS RADIATION OMISSION FOR MAJORITY WITH CLASSICAL HODGKIN LYMPHOMA AND MAINTAINS EXCELLENT OUTCOMES: A PHC PHASE 2 STUDY cHOD17 Open
View article: 373 | PROGNOSTIC VALUE OF 18F‐FDG PET/CT VOLUMETRIC PARAMETERS IN CHILDHOOD, ADOLESCENT, AND YOUNG ADULT HODGKIN LYMPHOMA: A SYSTEMATIC REVIEW FROM THE SEARCH GROUP
373 | PROGNOSTIC VALUE OF 18F‐FDG PET/CT VOLUMETRIC PARAMETERS IN CHILDHOOD, ADOLESCENT, AND YOUNG ADULT HODGKIN LYMPHOMA: A SYSTEMATIC REVIEW FROM THE SEARCH GROUP Open
View article: Phase 2 trial of veliparib, local irradiation, and temozolomide in patients with newly diagnosed high-grade glioma: a Children’s Oncology Group study
Phase 2 trial of veliparib, local irradiation, and temozolomide in patients with newly diagnosed high-grade glioma: a Children’s Oncology Group study Open
Background The outcome for pediatric patients with high-grade glioma (HGG) remains poor. Veliparib, a potent oral poly(adenosine diphosphate-ribose) polymerase (PARP) 1/2 inhibitor, enhances the activity of radiotherapy and DNA-damaging ch…
View article: OTHR-03. DEVELOPMENT OF PANORAMA: AN ASSESSMENT TOOL FOR PEDIATRIC NEURO-ONCOLOGY SERVICE DELIVERY CAPACITY
OTHR-03. DEVELOPMENT OF PANORAMA: AN ASSESSMENT TOOL FOR PEDIATRIC NEURO-ONCOLOGY SERVICE DELIVERY CAPACITY Open
BACKGROUND To enhance the quality of care available for children with central nervous system (CNS) tumors across the world, a systematic evaluation of service delivery capacity is needed to identify gaps in pediatric neuro-oncology and pri…
View article: MDB-49. OUTCOMES OF SONIC HEDGEHOG (SHH) MEDULLOBLASTOMA (MB) IN CHILDREN AND ADULTS TREATED WITH RISK-ADAPTED THERAPY ON A PROSPECTIVE INTERNATIONAL PROTOCOL (SJMB12)
MDB-49. OUTCOMES OF SONIC HEDGEHOG (SHH) MEDULLOBLASTOMA (MB) IN CHILDREN AND ADULTS TREATED WITH RISK-ADAPTED THERAPY ON A PROSPECTIVE INTERNATIONAL PROTOCOL (SJMB12) Open
BACKGROUND SJMB12 (NCT01878617) was among the first protocols to treat newly diagnosed MB incorporating molecular subgrouping. METHODS Tumors were subtyped and TP53 mutation assessed via immunohistochemistry. SHH patients were grouped into…
View article: MDB-92. EFFECT OF REDUCED-DOSE CRANIOSPINAL IRRADIATION AND REDUCED-DOSE ADJUVANT CHEMOTHERAPY ON CHILDREN AND ADOLESCENTS WITH WNT MEDULLOBLASTOMA WITHOUT RESIDUAL OR METASTATIC DISEASE: RESULTS FROM THE SJMB12 CLINICAL TRIAL
MDB-92. EFFECT OF REDUCED-DOSE CRANIOSPINAL IRRADIATION AND REDUCED-DOSE ADJUVANT CHEMOTHERAPY ON CHILDREN AND ADOLESCENTS WITH WNT MEDULLOBLASTOMA WITHOUT RESIDUAL OR METASTATIC DISEASE: RESULTS FROM THE SJMB12 CLINICAL TRIAL Open
BACKGROUND In response to studies showing medulloblastoma (MB) survival is not only contingent on clinical factors (e.g. metastases, residual disease) but also on molecular factors (e.g. molecular group, gene aberrations), we launched the …
View article: Imaging Assessment of Radiation Therapy-Related Normal Tissue Injury in Children: A PENTEC Visionary Statement
Imaging Assessment of Radiation Therapy-Related Normal Tissue Injury in Children: A PENTEC Visionary Statement Open
View article: Dosimetric effects of spleen motion for total lymphoid irradiation in pediatric proton therapy
Dosimetric effects of spleen motion for total lymphoid irradiation in pediatric proton therapy Open
View article: Accelerating pediatric Hodgkin lymphoma research: the Hodgkin Lymphoma Data Collaboration (NODAL)
Accelerating pediatric Hodgkin lymphoma research: the Hodgkin Lymphoma Data Collaboration (NODAL) Open
Data commons have proven to be an indispensable avenue for advancing pediatric cancer research by serving as unified information technology platforms that, when coupled with data standards, facilitate data sharing. The Pediatric Cancer Dat…
View article: Improved Cardiomyopathy Risk Prediction Using Global Longitudinal Strain and N-Terminal-Pro-B-Type Natriuretic Peptide in Survivors of Childhood Cancer Exposed to Cardiotoxic Therapy
Improved Cardiomyopathy Risk Prediction Using Global Longitudinal Strain and N-Terminal-Pro-B-Type Natriuretic Peptide in Survivors of Childhood Cancer Exposed to Cardiotoxic Therapy Open
PURPOSE To leverage baseline global longitudinal strain (GLS) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) to identify childhood cancer survivors with a normal left ventricular ejection fraction (LVEF) at highest risk of futur…
View article: Development of the pediatric neuro-oncology services assessment aid: An assessment tool for pediatric neuro-oncology service delivery capacity
Development of the pediatric neuro-oncology services assessment aid: An assessment tool for pediatric neuro-oncology service delivery capacity Open
Background To enhance the quality of care available for children with central nervous system (CNS) tumors across the world, a systematic evaluation of capacity is needed to identify gaps and prioritize interventions. To that end, we create…
View article: Interplay Effect of Splenic Motion for Total Lymphoid Irradiation in Pediatric Proton Therapy
Interplay Effect of Splenic Motion for Total Lymphoid Irradiation in Pediatric Proton Therapy Open
(1) Background: The most significant cause of an unacceptable deviation from the planned dose during respiratory motion is the interplay effect. We examined the correlation between the magnitude of splenic motion and its impact on plan qua…
View article: 869P Utilizing H&E images and digital pathology to predict response to buparlisib in SCCHN
869P Utilizing H&E images and digital pathology to predict response to buparlisib in SCCHN Open
View article: Validation of an automated contouring and treatment planning tool for pediatric craniospinal radiation therapy
Validation of an automated contouring and treatment planning tool for pediatric craniospinal radiation therapy Open
Purpose Treatment planning for craniospinal irradiation (CSI) is complex and time-consuming, especially for resource-constrained centers. To alleviate demanding workflows, we successfully automated the pediatric CSI planning pipeline in pr…
View article: CD19 CAR T-cell therapy demonstrates activity against extramedullary disease in pediatric patients with B-ALL
CD19 CAR T-cell therapy demonstrates activity against extramedullary disease in pediatric patients with B-ALL Open
[Figure: see text]
View article: Assessing the role of positron emission tomography and bone scintigraphy in imaging of pleuropulmonary blastoma (PPB): A report from the International PPB/<i>DICER1</i> Registry
Assessing the role of positron emission tomography and bone scintigraphy in imaging of pleuropulmonary blastoma (PPB): A report from the International PPB/<i>DICER1</i> Registry Open
Background Pleuropulmonary blastoma (PPB) is the most common primary lung neoplasm of infancy and early childhood. Given the rarity of PPB, the role of positron emission tomography (PET) and bone scintigraphy (bone scans) in diagnostic eva…
View article: Correlation between Multiparametric MR Imaging and Molecular Genetics in Pontine Pediatric High-Grade Glioma
Correlation between Multiparametric MR Imaging and Molecular Genetics in Pontine Pediatric High-Grade Glioma Open
ADC histogram parameters are correlated with histone H3 mutation status in pontine pediatric high-grade glioma.
View article: Predicting methylation class from diffusely infiltrating adult gliomas using multimodality MRI data
Predicting methylation class from diffusely infiltrating adult gliomas using multimodality MRI data Open
Background Radiogenomic studies of adult-type diffuse gliomas have used magnetic resonance imaging (MRI) data to infer tumor attributes, including abnormalities such as IDH-mutation status and 1p19q deletion. This approach is effective but…
View article: A Phase IV Trial of Proton Therapy in Children: The First Report from the SJPROTON1 Study
A Phase IV Trial of Proton Therapy in Children: The First Report from the SJPROTON1 Study Open
Importance Early reports suggest adverse events following proton therapy (PT) for childhood cancer are more prevalent given the increased number of PT centers and use in clinical trials. Objective To assess treatment-failure and toxicity e…
View article: Three‐dimensional dose and LET<sub>D</sub> prediction in proton therapy using artificial neural networks
Three‐dimensional dose and LET<sub>D</sub> prediction in proton therapy using artificial neural networks Open
Purpose Challenges in proton therapy include identifying patients most likely to benefit; ensuring consistent, high‐quality plans as its adoption becomes more widespread; and recognizing biological uncertainties that may be related to incr…
View article: P086: Advancing Pediatric Hodgkin Lymphoma Research Through NODAL
P086: Advancing Pediatric Hodgkin Lymphoma Research Through NODAL Open
Background: The Pediatric Cancer Data Commons (PCDC; University of Chicago, established in 2015) has provided a robust technical infrastructure to enable harmonization and utilization of big data to answer meaningful research questions for…
View article: Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/<i>DICER1</i> Registry
Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/<i>DICER1</i> Registry Open
PURPOSE Pleuropulmonary blastoma (PPB) is the most common primary lung neoplasm of infancy and early childhood. Type II and type III PPB have historically been associated with a poor prognosis. METHODS Patients with known or suspected PPB …
View article: Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children’s Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials
Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children’s Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials Open
View article: HGG-06. Phase 2 Study of Veliparib and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High-Grade Glioma without H3 K27M or BRAF Mutations: A Report from the Children's Oncology Group ACNS1721 Study
HGG-06. Phase 2 Study of Veliparib and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High-Grade Glioma without H3 K27M or BRAF Mutations: A Report from the Children's Oncology Group ACNS1721 Study Open
BACKGROUND: The outcome for pediatric patients with high-grade glioma (HGG) remains poor. Veliparib, a potent oral PARP1/2 inhibitor, enhances the activity of radiotherapy and DNA-damaging chemotherapy. Preclinical data indicates that veli…
View article: GCT-08. Patients with Metastatic Central Nervous System Germinoma Involving the Basal Ganglia and Thalami, a Case Series
GCT-08. Patients with Metastatic Central Nervous System Germinoma Involving the Basal Ganglia and Thalami, a Case Series Open
BACKGROUND: Central nervous system (CNS) germinomas are commonly located in the suprasellar and/or pineal regions. Current treatment strategies include irradiation (RT) alone or chemotherapy with RT to reduce the dose and field of RT. Howe…
View article: Risk factors associated with metastatic site failure in patients with high-risk neuroblastoma
Risk factors associated with metastatic site failure in patients with high-risk neuroblastoma Open
Incremental improvements in systemic therapy influence the patterns and type of metastatic site failure in neuroblastoma. Persistence of MIBG-avidity following induction chemotherapy and transplant at MSs increased the hazard for MSF.
View article: Pre- and Posttherapy Risk Factors for Vasculopathy in Pediatric Patients With Craniopharyngioma Treated With Surgery and Proton Radiation Therapy
Pre- and Posttherapy Risk Factors for Vasculopathy in Pediatric Patients With Craniopharyngioma Treated With Surgery and Proton Radiation Therapy Open
View article: Revised clinical and molecular risk strata define the incidence and pattern of failure in medulloblastoma following risk-adapted radiotherapy and dose-intensive chemotherapy: results from a phase III multi-institutional study
Revised clinical and molecular risk strata define the incidence and pattern of failure in medulloblastoma following risk-adapted radiotherapy and dose-intensive chemotherapy: results from a phase III multi-institutional study Open
Background We characterize the patterns of progression across medulloblastoma (MB) clinical risk and molecular subgroups from SJMB03, a Phase III clinical trial. Methods One hundred and fifty-five pediatric patients with newly diagnosed MB…
View article: CNS Radiation Necrosis in Pediatric Patients Treated With Pencil-Beam Scanning Proton Therapy: Interim Results From a Phase IV Surveillance Trial
CNS Radiation Necrosis in Pediatric Patients Treated With Pencil-Beam Scanning Proton Therapy: Interim Results From a Phase IV Surveillance Trial Open