Emile Tan
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View article: EuroSCORE II: Current limitations and physiological gaps in risk stratification
EuroSCORE II: Current limitations and physiological gaps in risk stratification Open
Risk stratification remains critical in cardiac surgery, enabling clinicians to predict adverse outcomes and guide perioperative management. The European System for Cardiac Operative Risk Evaluation (EuroSCORE) II, introduced in 2011, inco…
View article: Surgical Management of Rectal Gastrointestinal Stromal Tumours: Our Local Experience
Surgical Management of Rectal Gastrointestinal Stromal Tumours: Our Local Experience Open
Background: Surgical management of rectal gastrointestinal stromal tumours (GISTs) varies widely. Options include local excision (LE) or radical surgery (RS). Objectives: To describe our experience with the surgical management of rectal GI…
View article: CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer
CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer Open
Application of machine learning (ML) on cancer-specific pharmacogenomic datasets shows immense promise for identifying predictive response biomarkers to enable personalized treatment. We introduce CAN-Scan, a precision oncology platform, w…
View article: The Impact of COVID-19 Pandemic on the Diagnosis, Treatment, and Outcomes of Colorectal Cancer in Singapore
The Impact of COVID-19 Pandemic on the Diagnosis, Treatment, and Outcomes of Colorectal Cancer in Singapore Open
Background and Objectives: During the COVID-19 pandemic, many countries implemented lockdowns and social distancing measures, which may delay the early diagnosis of colorectal cancer (CRC). This study aims to review the impact of the pande…
View article: Trends in Early-Onset Colorectal Cancer in Singapore: Epidemiological Study of a Multiethnic Population
Trends in Early-Onset Colorectal Cancer in Singapore: Epidemiological Study of a Multiethnic Population Open
Background Colorectal cancer (CRC) incidence and mortality in those aged 50 years and above have decreased over the past 2 decades. However, there is a rising incidence of CRC among individuals under 50 years of age, termed early-onset col…
View article: Supplementary Figure S8 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S8 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
Role of Iron-(Fe3+) and Pirin in CRC
View article: Supplementary Figure S3 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S3 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
ITDRF-CETSA method identifying SP2509’s target.
View article: Supplementary Tables from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Tables from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
Supplementary Table S1: List of all the candidates from ITDRF-MS along with their function other than Pirin (second column shows the UniProt ID (protein accession number), third column shows gene ID, fourth column shows full protein name, …
View article: Supplementary Figure S4 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S4 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
Iron-(Fe3+) bound to Pirin positively regulates hTERT
View article: Supplementary Figure S10 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S10 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
SP2509 mediated inhibition of CRCs occurs due to loss of iron-(Fe3+) mediated Pirin activity
View article: Supplementary Figure S11 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S11 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
SP2509’s inhibitory action is specific to CRC specifically to CMS3 subtype
View article: Supplementary Figure S1 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S1 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
Validation of reporter cell lines for small molecule screens.
View article: Supplementary Figure S6 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S6 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
SP2509 competes with Iron-(Fe3+) bound to Pirin
View article: Supplementary Figure S9 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S9 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
Role of Iron-(Fe3+) and Pirin in CRC
View article: Supplementary Figure S5 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S5 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
SP2509 mediated regulation of TERT through Pirin
View article: Supplementary Figure S2 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S2 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
Effect of LSD1 on hTERT expression and telomerase activity.
View article: Data from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Data from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
Over-consumption of iron-rich red meat and hereditary or genetic iron overload are associated with an increased risk of colorectal carcinogenesis, yet the mechanistic basis of how metal-mediated signaling leads to oncogenesis remains enigm…
View article: Supplementary Figure S12 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S12 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
Regulation of Sp1 and FBXW7 levels by Pirin and SP2509
View article: Supplementary Figure S13 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S13 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
Iron-(Fe3+) regulates hTERT via Pirin-mediated control of FBXW7, the Sp1 targeting E3 ligase
View article: Supplementary Figure S7 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Supplementary Figure S7 from Iron-(Fe<sup>3+</sup>)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
SP2509 interaction with Iron-(Fe3+)
View article: Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers
Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers Open
Over-consumption of iron-rich red meat and hereditary or genetic iron overload are associated with an increased risk of colorectal carcinogenesis, yet the mechanistic basis of how metal-mediated signaling leads to oncogenesis remains enigm…
View article: Transvaginal versus transabdominal specimen extraction in minimally invasive surgery: a systematic review and meta-analysis
Transvaginal versus transabdominal specimen extraction in minimally invasive surgery: a systematic review and meta-analysis Open
Aim Natural orifice specimen extraction (NOSE) is an alternative to conventional transabdominal retrieval. We aimed to compare outcomes following transvaginal specimen extraction (TVSE) and transabdominal specimen extraction (TASE) in mini…
View article: Evaluating the surgical trainee ergonomic experience during minimally invasive abdominal surgery (ESTEEMA study)
Evaluating the surgical trainee ergonomic experience during minimally invasive abdominal surgery (ESTEEMA study) Open
Minimally invasive abdominal surgery (MAS) can exert a physical cost. Surgical trainees spend years assisting minimally-invasive surgeries, increasing the risk of workplace injury. This prospective questionnaire-based cohort study was cond…
View article: Venous thromboembolism among Asian populations with localized colorectal cancer undergoing curative resection: is pharmacological thromboprophylaxis required? A systematic review and meta-analysis
Venous thromboembolism among Asian populations with localized colorectal cancer undergoing curative resection: is pharmacological thromboprophylaxis required? A systematic review and meta-analysis Open
Purpose: We compared the incidence of venous thromboembolism (VTE) among Asian populations with localized colorectal cancer undergoing curative resection with and without the use of pharmacological thromboprophylaxis (PTP).Methods: A compr…
View article: Postoperative outcomes after prehabilitation for colorectal cancer patients undergoing surgery: a systematic review and meta-analysis of randomized and nonrandomized studies
Postoperative outcomes after prehabilitation for colorectal cancer patients undergoing surgery: a systematic review and meta-analysis of randomized and nonrandomized studies Open
Purpose: Prehabilitation (PH) is purported to improve patients’ preoperative functional status. This systematic review and meta-analysis sought to compare short-term postoperative outcomes between patients who underwent a protocolized PH p…