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View article: Interconnected Pathways and Therapeutic Implications for Cardiovascular Aging and Diseases
Interconnected Pathways and Therapeutic Implications for Cardiovascular Aging and Diseases Open
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, with their prevalence rising with advancing age. Progressive remodeling of the cardiovascular system during aging underlies increased vulnerability to cardiovascu…
View article: AMPK phosphorylates WIP1 to promote DNA repair and radioresistance in cancer cells
AMPK phosphorylates WIP1 to promote DNA repair and radioresistance in cancer cells Open
Cell metabolism has a profound impact on maintaining genomic stability. AMP-activated protein kinase (AMPK) is a crucial regulator of cell metabolism and the maintenance of genomic stability. There is increasing evidence that AMPK plays a …
View article: Genetically Engineered Senescence-Resistant Human Mesenchymal Progenitor Cells Promote Spinal Cord Injury Repair
Genetically Engineered Senescence-Resistant Human Mesenchymal Progenitor Cells Promote Spinal Cord Injury Repair Open
Spinal cord injury (SCI) is a devastating condition affecting the central nervous system, often leading to persistent neurological dysfunction. While mesenchymal progenitor cells (MPCs) hold considerable promise for treating various disord…
View article: <scp>WRKY27‐RAP2.7</scp> Regulatory Module Promotes Cold Tolerance via Modulation of Lignin Biosynthesis and Redox Homeostasis by Regulating <i>Cinnamyl Alcohol Dehydrogenase 7</i> and <i>Glutathione S‐Transferase F6</i>
<span>WRKY27‐RAP2.7</span> Regulatory Module Promotes Cold Tolerance via Modulation of Lignin Biosynthesis and Redox Homeostasis by Regulating <i>Cinnamyl Alcohol Dehydrogenase 7</i> and <i>Glutathione S‐Transferase F6</i> Open
Cold stress adversely affects plant growth and development, significantly limiting fruit yield and quality in citrus. Ichang papeda ( Citrus ichangensis ), a cold‐tolerant citrus species, serves as a valuable genetic resource for studying …
View article: The LysR-family transcriptional regulator VtlR coordinates carbon metabolism, oxidative and nitrosative stress resistance, and virulence in Brucella melitensis
The LysR-family transcriptional regulator VtlR coordinates carbon metabolism, oxidative and nitrosative stress resistance, and virulence in Brucella melitensis Open
Brucellosis, a globally significant zoonotic disease caused by Brucella infection, relies on the pathogen’s ability to invade and replicate within host cells. This intracellular replication is tightly regulated by transcriptional networks,…
View article: Biological Characterization and DIVA Potential of Three Rough Brucella melitensis Vaccine Strains
Biological Characterization and DIVA Potential of Three Rough Brucella melitensis Vaccine Strains Open
Background: Brucellosis is a zoonotic bacterial disease primarily controlled through quarantine, culling, and vaccination. Live attenuated vaccines remain the most effective countermeasure, yet their application is limited by residual viru…
View article: A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium
A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium Open
Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue …
View article: A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium
A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium Open
The visual system is essential for human perception, converting light signals into electrical impulses and transmitting them to the brain to process environmental information. As individuals age, their physiological functions gradually dec…
View article: <i>Chlorobaculum tepidum</i> outer membrane vesicles may transport biogenic elemental sulfur
<i>Chlorobaculum tepidum</i> outer membrane vesicles may transport biogenic elemental sulfur Open
Outer membrane-derived vesicles (OMVs) have been studied in different phyla of gram-negative bacteria, most extensively in the Pseudomonadota, where they have been shown to participate in diverse biological and environmental processes. To …
View article: Modified Fish‐Skin‐Collagen‐Based Hydrogels with Antioxidant and Antibacterial Functions for Diabetic Wound Healing
Modified Fish‐Skin‐Collagen‐Based Hydrogels with Antioxidant and Antibacterial Functions for Diabetic Wound Healing Open
Chronic wound management in diabetes represents a significant global medical challenge, primarily due to the complex microenvironment of diabetic wounds. Recently, fish‐skin‐collagen (Co)‐based hydrogels have gained attention for treating …
View article: The role of HSPB1 in modulating ferroptosis in pancreatic cancer via the TP53/SLC7A11/GPX4 axis
The role of HSPB1 in modulating ferroptosis in pancreatic cancer via the TP53/SLC7A11/GPX4 axis Open
HSPB1 promotes pancreatic cancer progression by suppressing TP53 signaling and increasing SLC7A11 and GPX4 expression, attenuating ferroptosis. These insights suggest HSPB1 as a potential therapeutic target, warranting further development …
View article: Integrating Disease Data and Toxicology Studies to Uncover the Mechanisms of Indium Tin Oxide (ITO) Nanoparticle-Induced Pulmonary Fibrosis and Develop an Adverse Outcome Pathway (AOP) Framework
Integrating Disease Data and Toxicology Studies to Uncover the Mechanisms of Indium Tin Oxide (ITO) Nanoparticle-Induced Pulmonary Fibrosis and Develop an Adverse Outcome Pathway (AOP) Framework Open
Exposure to indium tin oxide (ITO) nanoparticles (NPs) is strongly correlated with the development of indium lung disease. Preliminary studies have explored mechanisms of ITO NP-induced pulmonary toxicity, but a gap remains in effective me…
View article: Mitochondrial sirtuins, key regulators of aging
Mitochondrial sirtuins, key regulators of aging Open
Mitochondrial dysfunction is a hallmark of aging, characterized by a decline in mitochondrial biogenesis and quality control, compromised membrane integrity, elevated ROS production, damaged mitochondrial DNA (mtDNA), impaired mitochondria…
View article: Single-nucleus transcriptomics decodes the link between aging and lumbar disc herniation
Single-nucleus transcriptomics decodes the link between aging and lumbar disc herniation Open
Lumbar disc (LD) herniation and aging are prevalent conditions that can result in substantial morbidity. This study aimed to clarify the mechanisms connecting the LD aging and herniation, particularly focusing on cellular senescence and mo…
View article: Global PM2.5 exposures and inequalities
Global PM2.5 exposures and inequalities Open
Inequalities in exposure to PM2.5 reflect disproportionate distribution of health risks across populations. This study assesses global PM2.5 exposure inequalities and associated trends since 2000. Results show that 118 countries reduced in…
View article: Protocols for the application of human embryonic stem cell-derived neurons for aging modeling and gene manipulation
Protocols for the application of human embryonic stem cell-derived neurons for aging modeling and gene manipulation Open
In vitro models of neuronal aging and gene manipulation in human neurons (hNeurons) are valuable tools for investigating human brain aging and diseases. Here, we present a protocol for applying human embryonic stem cell (hESC)-derived neur…
View article: A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement
A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement Open
Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural environment. The advancement of human society is closely linked to the development of language,…
View article: Connecting the Patches: Exploring Multi-Scale Relations in Patches via Graph Neural Networks for Short-Term Electricity Load Forecasting
Connecting the Patches: Exploring Multi-Scale Relations in Patches via Graph Neural Networks for Short-Term Electricity Load Forecasting Open
Precise short-term forecasting of electricity load is essential to ensure the consistent and dependable functioning of power systems. Yet, the intricate and evolving relationships among load sequences and various external variables (e.g., …
View article: A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium
A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium Open
The skeletal muscle is an important organ for movement and metabolism in human body, and its physiological aging underlies the occurrence of muscle atrophy and sarcopenia. China has the largest aging population in the world and is facing a…
View article: Immunosenescence Inventory—a multi-omics database for immune aging research
Immunosenescence Inventory—a multi-omics database for immune aging research Open
The immune system is intricately interconnected with all other bodily systems. As individuals age, the immune system undergoes changes known as immunosenescence, increasing susceptibility to disease, and contributing significantly to the m…