John Thenganatt
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View article: The role of exercise right heart catheterization to guide pulmonary hypertension therapy in older adults
The role of exercise right heart catheterization to guide pulmonary hypertension therapy in older adults Open
The spectrum of patients referred for suspected pulmonary arterial hypertension (PAH) includes a population with clinical features suggestive of pulmonary hypertension due to left heart disease (PH‐LHD). Even after right heart catheterizat…
View article: Pulmonary endarterectomy in severe chronic thromboembolic pulmonary hypertension: the Toronto experience
Pulmonary endarterectomy in severe chronic thromboembolic pulmonary hypertension: the Toronto experience Open
The early and long-term results of PEA in patients with severe CTEPH are excellent despite greater postoperative risks. ECMO as a bridge to recovery after PEA can be useful in patients with severe CTEPH.
View article: Pathologically confirmed diffuse alveolar haemorrhage in lymphangioleiomyomatosis
Pathologically confirmed diffuse alveolar haemorrhage in lymphangioleiomyomatosis Open
A 40-year-old woman was referred to pulmonology after presenting with dyspnoea and self-limiting haemoptysis. Chest CT revealed diffuse ground glass opacities and small thin-walled cysts. Bronchoalveolar lavage cultures were negative and c…
View article: Characterizing Respiratory Mechanics in Lymphangioleiomyomatosis as Measured by Oscillometry
Characterizing Respiratory Mechanics in Lymphangioleiomyomatosis as Measured by Oscillometry Open
Rationale: Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease almost exclusively affecting women presenting as progressive pulmonary function loss and, in some instances, leading to respiratory failure.Approximately 70% of patien…
View article: Initial combination therapy with macitentan and tadalafil in pulmonary arterial hypertension: a retrospective cohort study
Initial combination therapy with macitentan and tadalafil in pulmonary arterial hypertension: a retrospective cohort study Open
Purpose: Initial combination therapy with ambrisentan and tadalafil has been demonstrated superior to either agent alone in pulmonary arterial hypertension (PAH). More recently, the OPTIMA trial showed efficacy of another combination of en…
View article: Importance of computed tomography in defining segmental disease in chronic thromboembolic pulmonary hypertension
Importance of computed tomography in defining segmental disease in chronic thromboembolic pulmonary hypertension Open
Background Radiological assessment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) is critical to decide whether patients should be treated with pulmonary endarterectomy (PEA). Although computed tomography pulmonary …
View article: Incident pulmonary arterial hypertension associated with Bosutinib
Incident pulmonary arterial hypertension associated with Bosutinib Open
Pulmonary arterial hypertension is associated with tyrosine kinase inhibitors used in the treatment of chronic myeloid leukemia. Dasatinib is a known cause of drug‐induced pulmonary arterial hypertension. There have been case reports linki…
View article: ANCA-Associated Vasculitis in a Man with Scleroderma and Pulmonary Fibrosis
ANCA-Associated Vasculitis in a Man with Scleroderma and Pulmonary Fibrosis Open
Systemic sclerosis is a connective tissue disease that is characterized by small-vessel vasculopathy, production of autoantibodies and fibroblast dysfunction resulting in increased deposition of extracellular matrix. It typically causes fi…
View article: Exhaled Nitric Oxide in Systemic Sclerosis Lung Disease
Exhaled Nitric Oxide in Systemic Sclerosis Lung Disease Open
Background . Exhaled nitric oxide (eNO) is a potential biomarker to distinguish systemic sclerosis (SSc) associated pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD). We evaluated the discriminative validity, feasib…
View article: A Case of Pulmonary Arterial Hypertension Associated with Adult Hemophagocytic Lymphohistiocytosis
A Case of Pulmonary Arterial Hypertension Associated with Adult Hemophagocytic Lymphohistiocytosis Open
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive, life‐threatening syndrome of excessive immune activation. Presentation is most common among the pediatric population, and cases in adults are rare. The number of nonhematologic pre…
View article: Role of extracorporeal life support after pulmonary endarterectomy: a single-centre experience
Role of extracorporeal life support after pulmonary endarterectomy: a single-centre experience Open
ECLS is a safe and important rescue option after PEA. The use of ECLS may expand eligibility for PEA by allowing sicker patients to undergo surgery.