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View article: Tissue-Specific Fluorescent Protein Turnover in Free-Moving Flies
Tissue-Specific Fluorescent Protein Turnover in Free-Moving Flies Open
Conditional transgenic systems and multi-copy target transgenes were used to produce transient fluorescent protein expression in adult Drosophila melanogaster, with the goal of developing an in vivo assay of protein turnover. Free-moving f…
View article: Tissue-Specific Fluorescent Protein Turnover in Free-Moving Flies
Tissue-Specific Fluorescent Protein Turnover in Free-Moving Flies Open
Conditional transgenic systems and multi-copy target transgenes were used to produce transient fluorescent protein expression in adult Drosophila melanogaster, with the goal of developing an in vivo assay of protein turnover. Free-moving f…
View article: Machine Learning Scoring Reveals Increased Frequency of Falls Proximal to Death in <i>Drosophila melanogaster</i>
Machine Learning Scoring Reveals Increased Frequency of Falls Proximal to Death in <i>Drosophila melanogaster</i> Open
Falls are a significant cause of human disability and death. Risk factors include normal aging, neurodegenerative disease, and sarcopenia. Drosophila melanogaster is a powerful model for study of normal aging and for modeling human neurode…
View article: Mifepristone and rapamycin have non-additive benefits for life span in mated female <i>Drosophila</i>
Mifepristone and rapamycin have non-additive benefits for life span in mated female <i>Drosophila</i> Open
The drugs mifepristone and rapamycin were compared for their relative ability to increase the life span of mated female Drosophila melanogaster. Titration of rapamycin indicated an optimal concentration of approximately 50 μM, which increa…
View article: Conditional Inhibition of Eip75B Eliminates the Effects of Mating and Mifepristone on Lifespan in Female Drosophila
Conditional Inhibition of Eip75B Eliminates the Effects of Mating and Mifepristone on Lifespan in Female Drosophila Open
Mating in female Drosophila melanogaster causes midgut hypertrophy and reduced lifespan, and these effects are blocked by the drug mifepristone. Eip75B is a transcription factor previously reported to have pleiotropic effects on Drosophila…
View article: Selectively advantageous instability in biotic and pre-biotic systems and implications for evolution and aging
Selectively advantageous instability in biotic and pre-biotic systems and implications for evolution and aging Open
Rules of biology typically involve conservation of resources. For example, common patterns such as hexagons and logarithmic spirals require minimal materials, and scaling laws involve conservation of energy. Here a relationship with the op…
View article: Dhr96[1] mutation and maternal tudor[1] mutation increase life span and reduce the beneficial effects of mifepristone in mated female Drosophila
Dhr96[1] mutation and maternal tudor[1] mutation increase life span and reduce the beneficial effects of mifepristone in mated female Drosophila Open
Mating and receipt of male Sex Peptide hormone cause increased egg laying, increased midgut size and decreased life span in female Drosophila. Feeding mated females with the synthetic steroid mifepristone decreases egg production, reduces …
View article: Markers and mechanisms of death in Drosophila
Markers and mechanisms of death in Drosophila Open
Parameters correlated with age and mortality in Drosophila melanogaster include decreased negative geotaxis and centrophobism behaviors, decreased climbing and walking speed, and darkened pigments in oenocytes and eye. Cessation of egg lay…
View article: A screen of small molecule and genetic modulators of life span in female <i>Drosophila</i> identifies etomoxir, RH5849 and unanticipated temperature effects
A screen of small molecule and genetic modulators of life span in female <i>Drosophila</i> identifies etomoxir, RH5849 and unanticipated temperature effects Open
Mifepristone increases life span in female Drosophila melanogaster, and its molecular target(s) remain unclear. Here small molecule and genetic interventions were tested for ability to mimic mifepristone, or to decrease life span in a way …
View article: Mifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity
Mifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity Open
Mifepristone dramatically increases the life span of mated female Drosophila while reducing the expression of innate immune response genes. Previous results indicated that mifepristone also reduced the load of aero-tolerant bacteria in mat…
View article: Mifepristone Increases Life Span of Virgin Female Drosophila on Regular and High-fat Diet Without Reducing Food Intake
Mifepristone Increases Life Span of Virgin Female Drosophila on Regular and High-fat Diet Without Reducing Food Intake Open
Background: The synthetic steroid mifepristone is reported to have anti-obesity and anti-diabetic effects in mammals on normal and high-fat diets (HFD). We previously reported that mifepristone blocks the negative effect on life span cause…
View article: In vivo assay and modelling of protein and mitochondrial turnover during aging
In vivo assay and modelling of protein and mitochondrial turnover during aging Open
To maintain homoeostasis, cells must degrade damaged or misfolded proteins and synthesize functional replacements. Maintaining a balance between these processes, known as protein turnover, is necessary for stress response and cellular adap…
View article: Impact papers on aging in 2009
Impact papers on aging in 2009 Open
The editorial board of Aging reviews research papers published in 2009, which they believe have or will have a significant impact on aging research. Among many others, the topics include genes that accelerate aging or in contrast promote l…
View article: Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide, and Mifepristone/RU486 in Female<i>Drosophila melanogaster</i>
Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide, and Mifepristone/RU486 in Female<i>Drosophila melanogaster</i> Open
Mating and transfer of male sex peptide (SP), or transgenic expression of SP, causes inflammation and decreased life span in female Drosophila. Mifepristone rescues these effects, yielding dramatic increases in life span. Here targeted met…
View article: Sexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis
Sexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis Open
External and internal stimuli cause modifications to gene and biochemical pathways. In turn, demonstrating that biological systems continuously make short-term adaptations both to set-points, and to the range of "normal" capacity, due to m…
View article: The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster
The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster Open
Hallmarks of aging include loss of protein homeostasis and dysregulation of stress-adaptive pathways. Loss of adaptive homeostasis, increases accumulation of DNA, protein, and lipid damage. During acute stress, the Cnc-C (Drosophila Nrf2 o…
View article: A review of the biomedical innovations for healthy longevity
A review of the biomedical innovations for healthy longevity Open
Aging | doi:10.18632/aging.101163. Alexey Moskalev, Vladimir Anisimov, Aleksander Aliper, Artem Artemov, Khusru Asadullah, Daniel Belsky, Ancha Baranova, Aubrey de Grey, Vishwa Deep Dixit, Edouard Debonneuil, Eugenia Dobrovolskaya, Peter F…