John Ukeri
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View article: The circularly permuted globin domain of androglobin exhibits atypical heme stabilization and nitric oxide interaction
The circularly permuted globin domain of androglobin exhibits atypical heme stabilization and nitric oxide interaction Open
Since the discovery of androglobin, a multi-domain hemoglobin associated with ciliogenesis and spermatogenesis, there has been little advance in the knowledge of the biochemical and structural properties of this member of the hemoglobin su…
View article: VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance
VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance Open
The COVID-19 pandemic demonstrated the need for rapid molecular diagnostics. Vaccination programs can provide protection and facilitate the opening of society, but newly emergent and existing viral variants capable of evading the immune sy…
View article: Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations
Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations Open
Cytoglobin is a hexacoordinate hemoglobin with physiological roles that are not clearly understood. Previously proposed physiological functions include nitric oxide regulation, oxygen sensing, or/and protection against oxidative stress und…
View article: The circularly permuted globin domain of Androglobin
The circularly permuted globin domain of Androglobin Open
Androglobin, is a recently discovered circularly permuted, multi-domain is hemoglobin. Using a remote homologue alignment method, coupled with molecular modelling and molecular dynamics, we identified the alignment to other hemoglobins. Th…
View article: VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance
VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance Open
The COVID-19 pandemic continues to pose a threat to the general population. The ongoing vaccination programs provide protection to individuals and facilitate the opening of society and a return to normality. However, emergent and existing …
View article: Studies of the effect of cysteine and heme pocket mutations of the nitric oxide dioxygenase and nitrite reductase activities of human Cytoglobin and Androglobin heme domain
Studies of the effect of cysteine and heme pocket mutations of the nitric oxide dioxygenase and nitrite reductase activities of human Cytoglobin and Androglobin heme domain Open
Oxygen delivery to hypoxic tissues along with the interplay between hemoglobins and hypoxic tissues have been an area of interest, the nitrite reductase activity (NiR) and the nitric oxide dioxygenase activity (NOD) working in tandem is a …