John V. Lin King
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View article: The Bordetella type III secretion system effector BteA targets host eosinophil-epithelial signaling to promote IL-1Ra expression and persistence
The Bordetella type III secretion system effector BteA targets host eosinophil-epithelial signaling to promote IL-1Ra expression and persistence Open
Eosinophils are traditionally associated with parasitic infections and allergic pathologies. However, emerging evidence highlights their underappreciated roles during mucosal bacterial infections. Using in vivo and in vitro approaches, we …
View article: Alpha-1 antitrypsin inhibits pertussis toxin
Alpha-1 antitrypsin inhibits pertussis toxin Open
Pertussis (whooping cough) is a vaccine-preventable but re-emerging, highly infectious respiratory disease caused by Bordetella pertussis. There are currently no effective treatments for pertussis, complicating care for nonvaccinated indiv…
View article: K <sub>v</sub> 1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis
K <sub>v</sub> 1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis Open
Significance Despite decades of research on adult neurogenesis, little is known about the role of bioelectric signaling in this process. In this study, we describe how a voltage-gated potassium channel, K v 1.1, supports adult neurogenesis…
View article: Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition Open
View article: Sensory TRP Channels in Three Dimensions
Sensory TRP Channels in Three Dimensions Open
Transient receptor potential (TRP) ion channels are sophisticated signaling machines that detect a wide variety of environmental and physiological signals. Every cell in the body expresses one or more members of the extended TRP channel fa…
View article: CryoEM of PreP prepared via Chameleon
CryoEM of PreP prepared via Chameleon Open
EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.
View article: CryoET of presequence protease single particle
CryoET of presequence protease single particle Open
EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.
View article: Irritant-evoked activation and calcium modulation of the TRPA1 receptor
Irritant-evoked activation and calcium modulation of the TRPA1 receptor Open
View article: Mechanisms governing irritant-evoked activation and calcium modulation of TRPA1
Mechanisms governing irritant-evoked activation and calcium modulation of TRPA1 Open
The TRPA1 ion channel is a chemosensory receptor that is critical for detecting noxious chemical agents that elicit or exacerbate pain or itch. Here we use structural and electrophysiological methods to elucidate how a broad class of react…
View article: A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain Open