John W. Cole
YOU?
Author Swipe
View article: Gravity, Spacetime, and Time
Gravity, Spacetime, and Time Open
Relating Newtonian gravity to relativistic theory has been a long-sought query. The accepted definition of Newtonian gravity calculates the magnitude of the attractive force between 2 objects as equal to G (the gravitational constant) mult…
View article: Gravity, Spacetime, and Time
Gravity, Spacetime, and Time Open
Gravity is a fundamental force that has long been studied with both Newtonian and relativistic theories providing calculable real-world solutions. Until now the relationship between these two theories has been uncertain. The following manu…
View article: The association of SUR1 polymorphisms with acute infarct size: The MRI-GENIE study
The association of SUR1 polymorphisms with acute infarct size: The MRI-GENIE study Open
rs7105832, rs2237982, rs11024286, rs4148622 polymorphisms of the ABCC8 gene did not demonstrate a significant effect on acute ischemic infarct size or 3-month functional outcome. Nonetheless, further studies with delayed imaging and more s…
View article: Genome-Wide Association Studies of 3 Distinct Recovery Phenotypes in Mild Ischemic Stroke
Genome-Wide Association Studies of 3 Distinct Recovery Phenotypes in Mild Ischemic Stroke Open
Defining domain-specific stroke recovery phenotypes and using longitudinal clinical trial designs can help detect novel genes associated with chronic recovery. These data support the use of granular endpoints to identify genetic associatio…
View article: Lifetime and Acute Stress Predict Functional Outcomes Following Stroke: Findings From the Longitudinal STRONG Study
Lifetime and Acute Stress Predict Functional Outcomes Following Stroke: Findings From the Longitudinal STRONG Study Open
BACKGROUND: Stroke is a sudden-onset, uncontrollable event; stroke-related stress may impede rehabilitation and recovery. Lifetime stress may sensitize patients to experiencing greater stroke-related stress and indirectly affect outcomes. …
View article: Genomic risk scores and oral contraceptive-associated ischemic stroke risk: a call for collaboration
Genomic risk scores and oral contraceptive-associated ischemic stroke risk: a call for collaboration Open
Background Oral contraceptives (OCs) are generally safe but vascular risk factors increase OC-associated ischemic stroke risk. We performed a case-control study to evaluate whether a genomic risk score for ischemic stroke modifies OC-assoc…
View article: A novel scatterplot-based method to detect copy number variation (CNV)
A novel scatterplot-based method to detect copy number variation (CNV) Open
Objective: Most methods to detect copy number variation (CNV) have high false positive rates, especially for small CNVs and in real-life samples from clinical studies. In this study, we explored a novel scatterplot-based method to detect C…
View article: Rehabilitation Therapy Doses Are Low After Stroke and Predicted by Clinical Factors
Rehabilitation Therapy Doses Are Low After Stroke and Predicted by Clinical Factors Open
Background: Stroke is a leading cause of long-term disability. Greater rehabilitation therapy after stroke is known to improve functional outcomes. This study examined therapy doses during the first year of stroke recovery and identified f…
View article: Surgical Learners Do Not Teach Skills According to How They Were Taught
Surgical Learners Do Not Teach Skills According to How They Were Taught Open
Background: Surgeons are expected to teach students, residents and colleagues about surgical skills. The critical assumption that a “first-learner” will default to teaching a “second-learner” what they were taught, in the way they were tau…
View article: Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium
Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium Open
Recent genome wide association studies have identified 89 common genetic variants robustly associated with ischemic stroke and primarily located in non-coding regions. To evaluate the contribution of coding variants, which are mostly rare,…
View article: Genetic diversity fuels gene discovery for tobacco and alcohol use
Genetic diversity fuels gene discovery for tobacco and alcohol use Open
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury 1–4 . These substances are used across the globe, yet genome-wide a…
View article: Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke
Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke Open
T2-FLAIR radiomics can be used to predict brain age and derive RBA. Older-appearing brains, characterized by a higher RBA, reflect cardiovascular risk factor accumulation and are linked to worse outcomes after stroke.
View article: The relevance of rich club regions for functional outcome post‐stroke is enhanced in women
The relevance of rich club regions for functional outcome post‐stroke is enhanced in women Open
This study aimed to investigate the influence of stroke lesions in predefined highly interconnected (rich‐club) brain regions on functional outcome post‐stroke, determine their spatial specificity and explore the effects of biological sex …
View article: Exome Array Analysis of 9,721 ischemic stroke cases from the SiGN Consortium
Exome Array Analysis of 9,721 ischemic stroke cases from the SiGN Consortium Open
Recent studies have identified > 40 genetic variants robustly associated with ischemic stroke, most identified through genome wide association studies and primarily marking common variants in non-coding regions presumed to have regulatory …
View article: Updated Stroke Gene Panels: Rapid evolution of knowledge on monogenic causes of stroke
Updated Stroke Gene Panels: Rapid evolution of knowledge on monogenic causes of stroke Open
This article updates our previous Stroke Gene Panels (SGP) from 2017. Online Mendelian Inheritance in Man and PubMed were searched. We divided detected genes into two SGP groups, SGP1: genes reported in at least one person with stroke and …
View article: Genomic Risk Scores and Oral Contraceptive-Associated Ischemic Stroke Risk
Genomic Risk Scores and Oral Contraceptive-Associated Ischemic Stroke Risk Open
Background Oral contraceptives (OCs) are generally safe but vascular risk factors increase OC-associated ischemic stroke risk. We performed a case-control study to evaluate whether a genomic risk score for ischemic stroke modifies OC-assoc…
View article: Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention Open
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of…
View article: Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke Open
The ABO locus, genetically predicted blood group A, and higher genetic propensity for venous thrombosis are more strongly associated with EOS than with LOS, supporting a stronger role of prothrombotic factors in EOS.
View article: Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics
Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics Open
Background purpose A substantial number of patients with acute ischemic stroke (AIS) experience multiple acute lesions (MAL). We here aimed to scrutinize MAL in a large radiologically deep-phenotyped cohort. Materials and methods Analyses …
View article: Mildly elevated INR is associated with worse outcomes following mechanical thrombectomy for acute ischemic stroke
Mildly elevated INR is associated with worse outcomes following mechanical thrombectomy for acute ischemic stroke Open
Background Elevated International Normalized Ratio (INR) is a marker of coagulopathy, but its impact on outcomes following mechanical thrombectomy (MT) in patients with stroke is unclear. This study investigates the impact of mild INR elev…
View article: Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome
Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome Open
Higher WMH burden may be associated with an increased stroke severity in case of stroke lesions involving left-hemispheric insular, opercular, and inferior frontal regions (potentially linked to language functions) and right-hemispheric te…
View article: Updated Stroke Gene Panels: Rapid evolution of knowledge on monogenic causes of stroke
Updated Stroke Gene Panels: Rapid evolution of knowledge on monogenic causes of stroke Open
This article updates our previous Stroke Gene Panels (SGP) from 2017. Online Mendelian Inheritance in Man and PubMed were searched. We divided detected genes into two SGP groups, SGP1: genes reported in at least one person with stroke and …
View article: Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics
Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics Open
Background A substantial number of patients with acute ischemic stroke (AIS) experience multiple acute lesions (MAL). However, the spatial distribution and clinical implications of such MAL are incompletely understood. Methods Analyses rel…
View article: The relevance of rich club regions for functional outcome post-stroke is enhanced in women
The relevance of rich club regions for functional outcome post-stroke is enhanced in women Open
This study aimed to investigate the influence of stroke lesions in pre-defined highly interconnected (rich club) brain regions on functional outcome post-stroke, determine their spatial specificity and explore the effects of biological sex…
View article: Differences in Multiple Risk Factors Between Black and White Individuals With Young-Onset Ischemic Stroke
Differences in Multiple Risk Factors Between Black and White Individuals With Young-Onset Ischemic Stroke Open
The risk of stroke in young adults increased exponentially with the number of risk factors. Young Black patients with ischemic stroke were approximately 6 times more likely to have the co-occurrence of obesity, hypertension, diabetes, and …