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View article: A balanced circadian glycolytic rhythm drives cardiomyocyte cell cycle progression during fish heart regeneration
A balanced circadian glycolytic rhythm drives cardiomyocyte cell cycle progression during fish heart regeneration Open
The ability of heart tissue to repair itself after injury has fascinated scientists for decades 1,2 . Researchers have long studied the internal body clock, or circadian rhythm, for its role in coordinating daily cycles of metabolism and c…
View article: Handheld Spatially Offset Raman Spectroscopy for rapid non-invasive detection of ethylene glycol and diethylene glycol in medicinal syrups
Handheld Spatially Offset Raman Spectroscopy for rapid non-invasive detection of ethylene glycol and diethylene glycol in medicinal syrups Open
We investigate the potential of Spatially Offset Raman Spectroscopy (SORS) as a rapid, non-invasive screening tool deployable in the field to detect diethylene glycol (DEG) and ethylene glycol (EG) in medicinal syrups within closed contain…
View article: Ensuring vaccine cold chain integrity: A rapid and low-cost test for identifying heat-exposed sucrose-containing vaccines
Ensuring vaccine cold chain integrity: A rapid and low-cost test for identifying heat-exposed sucrose-containing vaccines Open
Maintaining cold-chain integrity is vital for vaccines to ensure they remained within the recommended temperature limits to ensure stability and avoid degradation as storage temperature is one of the key factors contributing to rendering p…
View article: Integrating NMR and multi-LC-MS-based untargeted metabolomics for comprehensive analysis of blood serum samples
Integrating NMR and multi-LC-MS-based untargeted metabolomics for comprehensive analysis of blood serum samples Open
Using a single clinical serum aliquot for simultaneous untargeted profiling via NMR and multi-LC-MS represents a highly efficient alternative to current methods. This approach reduces sample volume requirements and substantially expands th…
View article: Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism Open
Asparagine levels are reduced in patients with diabetes and alcoholism. A plausible mechanism is that aldehydes elevated in these diseases react with the N-terminal cysteine of asparagine synthetase B, so inhibiting asparagine production.
View article: Innovative method for rapid detection of falsified COVID-19 vaccines through unopened vials using handheld Spatially Offset Raman Spectroscopy (SORS)
Innovative method for rapid detection of falsified COVID-19 vaccines through unopened vials using handheld Spatially Offset Raman Spectroscopy (SORS) Open
Preventing, detecting, and responding to substandard and falsified vaccines is of critical importance for ensuring the safety, efficacy, and public trust in vaccines. This is of heightened importance in context of public health crisis, suc…
View article: Ion-Exchange Chromatography Coupled to Mass Spectrometry in Life Science, Environmental, and Medical Research
Ion-Exchange Chromatography Coupled to Mass Spectrometry in Life Science, Environmental, and Medical Research Open
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTIon-Exchange Chromatography Coupled to Mass Spectrometry in Life Science, Environmental, and Medical ResearchJudith B. NgereJudith B. NgereDepartment of Chemistry, University of Oxford, Mansfield …
View article: Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation
Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation Open
Depleting the microenvironment of important nutrients such as arginine is a key strategy for immune evasion by cancer cells. Many tumors overexpress arginase, but it is unclear how these cancers, but not T cells, tolerate arginine depletio…
View article: Tibetan <i>PHD2</i> , an allele with loss-of-function properties
Tibetan <i>PHD2</i> , an allele with loss-of-function properties Open
Significance Tibetans have lived for thousands of years at an altitude where oxygen concentrations are low (hypoxia). They are known to have physiologic adaptations, including increased breathing responses to low oxygen and decreased blood…
View article: Investigating isocitrate dehydrogenase mutations in cancer using new metabolomics methods
Investigating isocitrate dehydrogenase mutations in cancer using new metabolomics methods Open
Altered cellular metabolism, as a result of oncogenic mutations, has been observed in a range of cancer types. A detailed understanding of how cancers modify cellular metabolism, which includes changes to the genome, proteome and metabolom…
View article: Rapid intraoperative molecular genetic classification of gliomas using Raman spectroscopy
Rapid intraoperative molecular genetic classification of gliomas using Raman spectroscopy Open
Background The molecular genetic classification of gliomas, particularly the identification of isocitrate dehydrogenase (IDH) mutations, is critical for clinical and surgical decision-making. Raman spectroscopy probes the unique molecular …