Jason D. Warren
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View article: Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group
Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group Open
Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International …
View article: Speech‐in‐noise processing in Alzheimer's disease and primary progressive aphasia
Speech‐in‐noise processing in Alzheimer's disease and primary progressive aphasia Open
Background In daily life, understanding spoken messages generally requires decoding of speech signals embedded in variably noisy acoustic backgrounds. This is a computationally demanding neural task that is likely to be vulnerable early in…
View article: Genetic and Pathological Characteristics of Frontotemporal Dementia with Right Anterior Temporal Predominance: A Multicenter Retrospective Cohort Study
Genetic and Pathological Characteristics of Frontotemporal Dementia with Right Anterior Temporal Predominance: A Multicenter Retrospective Cohort Study Open
Background Frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominant atrophy is an emerging area of interest. Recent findings by the International Working Group (IWG) have identified this subtype as having a distin…
View article: Non‐verbal dichotic listening: a new, cross‐cultural central hearing test for dementia
Non‐verbal dichotic listening: a new, cross‐cultural central hearing test for dementia Open
Background Difficulties with auditory scene analysis (the process of parsing the auditory environment into its constituent sound objects) are an early feature of Alzheimer's disease. Previous research has shown that tests of auditory scene…
View article: (DIADEM) Digital Assessment of Auditory Perception in Dementia : Study Protocol
(DIADEM) Digital Assessment of Auditory Perception in Dementia : Study Protocol Open
Background In Alzheimer's disease (AD), disruption of neural circuits in temporoparietal cortical areas leads to early auditory dysfunction, such as impaired speech‐in‐noise perception. Research shows that poorer speech‐in‐noise performanc…
View article: Barriers and facilitators to implementing synchronous telehealth interventions for people with dementia - a systematic review
Barriers and facilitators to implementing synchronous telehealth interventions for people with dementia - a systematic review Open
Introduction: Behavioural interventions, such as those provided by allied health professionals and psychologists, help manage symptoms of people living with dementia. Access to such interventions depends on individual factors (e.g., suppor…
View article: The emotional journey through the stages of primary progressive aphasia: seven co-produced care pathway recommendations for clinical practice
The emotional journey through the stages of primary progressive aphasia: seven co-produced care pathway recommendations for clinical practice Open
Primary progressive aphasia (PPA) describes a group of language-led dementias associated with frontotemporal dementia and Alzheimer’s disease. Speech and language therapy is the main intervention for PPA. Yet, there remains little guidance…
View article: Acoustically Altered Speech Perception in Frontotemporal Dementia Syndromes
Acoustically Altered Speech Perception in Frontotemporal Dementia Syndromes Open
AAS perception stratifies FTD syndromes and constitutes a "real-world audiogram" in these diseases.
View article: Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta-analysis
Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta-analysis Open
Hearing loss has been linked with cognitive decline and increased dementia risk. The neurobiological mechanisms underlying this relationship are not clear. In this systematic review and meta-analysis, we evaluated associations between hear…
View article: Hearing impairment and dementia: cause, catalyst or consequence?
Hearing impairment and dementia: cause, catalyst or consequence? Open
The relationship between hearing impairment and dementia has attracted significant attention, the 2024 Lancet Commission report identifying hearing loss as the largest modifiable risk factor for dementia from mid-life. The nature of this l…
View article: Seasonal changes in physical oceanography modulate cetacean predator-prey dynamics in the San Diego Trough
Seasonal changes in physical oceanography modulate cetacean predator-prey dynamics in the San Diego Trough Open
In marine ecosystems, cetaceans are large mobile predators that depend on maximizing foraging efficiency. Their presence within a habitat can therefore be strongly related to the modulation of local prey by oceanographic conditions. Unders…
View article: Social cognition in mild cognitive impairment and dementia: A systematic review and meta‐analysis
Social cognition in mild cognitive impairment and dementia: A systematic review and meta‐analysis Open
Social cognition is impaired in people with dementia but the differences in social cognitive impairment between mild cognitive impairment (MCI) and dementia and its subtypes remain unclear. We therefore aimed to systematically review and m…
View article: “A torch, a rope, a belly laugh”: engaging with the multiple voices of support groups for people living with rare dementia
“A torch, a rope, a belly laugh”: engaging with the multiple voices of support groups for people living with rare dementia Open
Purpose Rare forms of dementia bring unique difficulties related to age of onset, impact on family commitments, employment and finances, and also bring distinctive needs for support and care. The aim of the present study was to explore and…
View article: Associations between night/shift working and late-life brain health
Associations between night/shift working and late-life brain health Open
Sleep and circadian disturbances are associated with increased dementia risk. The mechanism remains poorly understood. We aimed to examine the relationship between night/shift working at age 31 and biomarkers of late-life brain health and …
View article: Comprehension of acoustically degraded emotional prosody in Alzheimer’s disease and primary progressive aphasia
Comprehension of acoustically degraded emotional prosody in Alzheimer’s disease and primary progressive aphasia Open
Previous research suggests that emotional prosody perception is impaired in neurodegenerative diseases like Alzheimer’s disease (AD) and primary progressive aphasia (PPA). However, no previous research has investigated emotional prosody pe…
View article: Primary progressive aphasia in Italian and English: a cross‐linguistic cohort study
Primary progressive aphasia in Italian and English: a cross‐linguistic cohort study Open
Background Primary Progressive Aphasia (PPA) is a neurodegenerative disorder primarily affecting language abilities, with clinical variants (nonfluent/agrammatic variant [nfvPPA], semantic variant [svPPA], logopenic variant [lvPPA], and mi…
View article: Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta‐analysis
Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta‐analysis Open
Background Various explanations have been proposed for how hearing impairment might be associated with increased risk of dementia. Several theories have proposed direct links with Alzheimer’s disease (AD) neuropathology, either due to shar…
View article: The auditory phenotype of behavioural variant and right temporal variant frontotemporal dementia
The auditory phenotype of behavioural variant and right temporal variant frontotemporal dementia Open
Background Patients with behavioural variant frontotemporal dementia (bvFTD) and right temporal variant frontotemporal dementia (rtvFTD) commonly exhibit abnormal hedonic and other behavioural responses to sounds, however hearing dysfuncti…
View article: Dysphagia in primary progressive aphasia: clinical predictors and neuroanatomical basis
Dysphagia in primary progressive aphasia: clinical predictors and neuroanatomical basis Open
Background Dysphagia is an important feature of neurodegenerative diseases and potentially life‐threatening in primary progressive aphasia (PPA), but remains poorly characterised in these syndromes. We hypothesised that dysphagia would be …
View article: The dynamics of auditory working memory impairment in logopenic variant primary progressive aphasia and typical Alzheimer’s disease
The dynamics of auditory working memory impairment in logopenic variant primary progressive aphasia and typical Alzheimer’s disease Open
Background Impaired auditory verbal working memory is a diagnostic hallmark and integral driver of the clinical phenotype in logopenic variant primary progressive aphasia (lvPPA). However, the physiology of the working memory buffer in thi…
View article: Shift and night work in the fourth decade is associated with reduced brain volume in late life independent of amyloidogenic pathways: an Insight 46 study
Shift and night work in the fourth decade is associated with reduced brain volume in late life independent of amyloidogenic pathways: an Insight 46 study Open
Background Sleep and circadian disruption are associated with increased dementia risk, yet the mechanism remains poorly understood. We examined the relationship between night/shift working in the fourth decade and late‐life brain health. W…
View article: Music To My Eyes? Exploring the pupil old/new effect to familiar and unfamiliar music in people with logopenic variant Primary Progressive Aphasia
Music To My Eyes? Exploring the pupil old/new effect to familiar and unfamiliar music in people with logopenic variant Primary Progressive Aphasia Open
Background Responses to individualized music in people living with dementia can be indicated by both verbal and non‐verbal cues. Evidence suggests that elevated pupil dilation responses to familiar vs. unfamiliar music are preserved in peo…
View article: Disruption of macroscale functional network organisation in patients with frontotemporal dementia
Disruption of macroscale functional network organisation in patients with frontotemporal dementia Open
Neurodegenerative dementias have a profound impact on higher-order cognitive and behavioural functions. Investigating macroscale functional networks through cortical gradients provides valuable insights into the neurodegenerative dementia …
View article: An international core outcome set for primary progressive aphasia (COS‐PPA): Consensus‐based recommendations for communication interventions across research and clinical settings
An international core outcome set for primary progressive aphasia (COS‐PPA): Consensus‐based recommendations for communication interventions across research and clinical settings Open
INTRODUCTION: Interventions to treat speech-language difficulties in primary progressive aphasia (PPA) often use word accuracy as a highly comparable outcome. However, there are more constructs of importance to people with PPA that have re…
View article: Primary Progressive Aphasia in Italian and English
Primary Progressive Aphasia in Italian and English Open
Language-specific characteristics influenced PPA phenotypes, with more frequent expressive agrammatism in Italian (reflecting its morphologic complexity), more frequently impaired word processing in English (reflecting its articulatory, ac…
View article: An international core outcome set for primary progressive aphasia (COS‐PPA): Consensus‐based recommendations for communication interventions across research and clinical settings
An international core outcome set for primary progressive aphasia (COS‐PPA): Consensus‐based recommendations for communication interventions across research and clinical settings Open
INTRODUCTION Interventions to treat speech‐language difficulties in primary progressive aphasia (PPA) often use word accuracy as a highly comparable outcome. However, there are more constructs of importance to people with PPA that have rec…
View article: Clinical Recognition of Frontotemporal Dementia with Right Temporal Predominance; Consensus Recommendations of the International Working Group
Clinical Recognition of Frontotemporal Dementia with Right Temporal Predominance; Consensus Recommendations of the International Working Group Open
Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International …