John Whyte
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View article: Population genomics of yellow-eyed penguins uncovers subspecies divergence and candidate genes linked to respiratory distress syndrome
Population genomics of yellow-eyed penguins uncovers subspecies divergence and candidate genes linked to respiratory distress syndrome Open
Yellow-eyed penguins (hoiho/takaraka, Megadyptes antipodes) are among the world's rarest penguins and are regarded as a taonga (treasured) species in Aotearoa New Zealand. Since 2019, chicks on the New Zealand mainland have been affected b…
View article: Comparing Two Models of Transition from Inpatient Rehabilitation Following Traumatic Brain Injury: A Pragmatic Comparative Effectiveness Trial
Comparing Two Models of Transition from Inpatient Rehabilitation Following Traumatic Brain Injury: A Pragmatic Comparative Effectiveness Trial Open
Moderate to severe traumatic brain injury (msTBI) results in physical, cognitive, behavioral, and psychosocial difficulties. Those who receive inpatient rehabilitation following a msTBI need assistance after discharge. Patients and their f…
View article: Developing Cognitive Control Training for Aphasia: Insights From Treatment Theory and Enablement Theory
Developing Cognitive Control Training for Aphasia: Insights From Treatment Theory and Enablement Theory Open
View article: Maintenance with niraparib in patients with stage III, stage IV, chemo-naïve recurrent or platinum-sensitive recurrent uterine serous carcinoma: study protocol for a phase II clinical trial
Maintenance with niraparib in patients with stage III, stage IV, chemo-naïve recurrent or platinum-sensitive recurrent uterine serous carcinoma: study protocol for a phase II clinical trial Open
Introduction Uterine serous carcinoma (USC) accounts for 40% of endometrial cancer-related deaths. The standard of care for stages III and IV USC yields a 20%–30% survival at 2 years and a 10%–20% survival at 3–5 years. Recent advances in …
View article: Brain Injury Rehabilitation: Improving the Transition Experience (BRITE)
Brain Injury Rehabilitation: Improving the Transition Experience (BRITE) Open
View article: Cervical adenocarcinoma presenting as an ovarian torsion
Cervical adenocarcinoma presenting as an ovarian torsion Open
Mucinous adenocarcinoma in the ovary is usually a metastasis and an extensive and comprehensive work-up is required to try to locate the primary tumor.Précis: Mucinous adenocarcinoma in the ovary is usually a metastasis and an extensive an…
View article: Using the Rehabilitation Treatment Specification System to Describe Experimental and Control Arms of a Clinical Trial for Breast Cancer Survivors
Using the Rehabilitation Treatment Specification System to Describe Experimental and Control Arms of a Clinical Trial for Breast Cancer Survivors Open
Background: The Rehabilitation Treatment Specification System (RTSS) provides a framework to decompose complex interventions into components, each defined by its known or hypothesized active ingredients. In addition to its value in plannin…
View article: Defining paediatric neurorehabilitation: You cannot improve what you cannot characterize
Defining paediatric neurorehabilitation: You cannot improve what you cannot characterize Open
Neurorehabilitation is the primary therapy for neurological impairment in children, yet its potential to achieve change remains incompletely understood and probably underestimated. Understanding ‘the difference neurorehabilitation can make…
View article: Rehabilitation Treatment Specification System: Content and Criterion Validity Across Evidence-Based Voice Therapies for Muscle Tension Dysphonia
Rehabilitation Treatment Specification System: Content and Criterion Validity Across Evidence-Based Voice Therapies for Muscle Tension Dysphonia Open
Purpose: Systematically improving voice therapy outcomes is challenging as the clinician actions (i.e., active ingredients) responsible for improved patient functioning (i.e., targets) are relatively unknown. The theory-driven Rehabilitati…
View article: Rehabilitation Treatment Specification System for Voice Therapy: Application to Everyday Clinical Care
Rehabilitation Treatment Specification System for Voice Therapy: Application to Everyday Clinical Care Open
Purpose: Rehabilitation intervention descriptions often do not explicitly identify active ingredients or how those ingredients lead to changes in patient functioning. The Rehabilitation Treatment Specification System (RTSS) provides guidan…
View article: Common Data Element for Disorders of Consciousness: Recommendations from the Working Group on Therapeutic Interventions
Common Data Element for Disorders of Consciousness: Recommendations from the Working Group on Therapeutic Interventions Open
The newly created CRF enhances systematization of future work by proposing a portfolio of measures that should be collected in the development and implementation of studies assessing novel interventions intended to increase the level of co…
View article: Common Data Element for Disorders of Consciousness: Recommendations from the Working Group on Therapeutic Interventions
Common Data Element for Disorders of Consciousness: Recommendations from the Working Group on Therapeutic Interventions Open
Background. Over the past thirty years, there have been significant advances in the understanding of the mechanisms associated with loss and recovery of consciousness following severe brain injury. This work has provided a strong grounding…
View article: How Severe Is Severe Disability After Traumatic Brain Injury? Response to Sarigul B et al., <i>Prognostication and goals of care decisions in Severe traumatic brain injury: A survey of the Seattle International Severe Traumatic Brain Injury Consensus Conference Working Group</i> (DOI: 10.1089/neu.2022.0414)
How Severe Is Severe Disability After Traumatic Brain Injury? Response to Sarigul B et al., <i>Prognostication and goals of care decisions in Severe traumatic brain injury: A survey of the Seattle International Severe Traumatic Brain Injury Consensus Conference Working Group</i> (DOI: 10.1089/neu.2022.0414) Open
View article: Spatiotemporal profile of atrophy in the first year following moderate‐severe traumatic brain injury
Spatiotemporal profile of atrophy in the first year following moderate‐severe traumatic brain injury Open
Traumatic brain injury (TBI) triggers progressive neurodegeneration resulting in brain atrophy that continues months‐to‐years following injury. However, a comprehensive characterization of the spatial and temporal evolution of TBI‐related …
View article: Temporal dynamics of cerebral blood flow during the first year after moderate-severe traumatic brain injury: A longitudinal perfusion MRI study
Temporal dynamics of cerebral blood flow during the first year after moderate-severe traumatic brain injury: A longitudinal perfusion MRI study Open
Traumatic brain injury (TBI) is associated with alterations in cerebral blood flow (CBF), which may underlie functional disability and precipitate TBI-induced neurodegeneration. Although it is known that chronic moderate-severe TBI (msTBI)…
View article: Rehabilitation Treatment Specification System: Identifying Barriers, Facilitators, and Strategies for Implementation in Research, Education, and Clinical Care
Rehabilitation Treatment Specification System: Identifying Barriers, Facilitators, and Strategies for Implementation in Research, Education, and Clinical Care Open
View article: Feasibility and Utility of a Flexible Outcome Assessment Battery for Longitudinal Traumatic Brain Injury Research: A TRACK-TBI Study
Feasibility and Utility of a Flexible Outcome Assessment Battery for Longitudinal Traumatic Brain Injury Research: A TRACK-TBI Study Open
The effects of traumatic brain injury (TBI) are difficult to measure in longitudinal cohort studies, because disparate pre-injury characteristics and injury mechanisms produce variable impairment profiles and recovery trajectories. In prep…
View article: Incidence and prevalence of coma in the UK and the USA
Incidence and prevalence of coma in the UK and the USA Open
The epidemiology of coma is unknown because case ascertainment with traditional methods is difficult. Here, we used crowdsourcing methodology to estimate the incidence and prevalence of coma in the UK and the USA. We recruited UK and US la…
View article: Determining the Hierarchy of Coma Recovery Scale-Revised Rating Scale Categories and Alignment with Aspen Consensus Criteria for Patients with Brain Injury: A Rasch Analysis
Determining the Hierarchy of Coma Recovery Scale-Revised Rating Scale Categories and Alignment with Aspen Consensus Criteria for Patients with Brain Injury: A Rasch Analysis Open
This study aimed to empirically evaluate the hierarchical structure of the Coma Recovery Scale-Revised (CRS-R) rating scale categories and their alignment with the Aspen consensus criteria for determining disorders of consciousness (DoC) f…
View article: Connectomic assessment of injury burden and longitudinal structural network alterations in moderate‐to‐severe traumatic brain injury
Connectomic assessment of injury burden and longitudinal structural network alterations in moderate‐to‐severe traumatic brain injury Open
Traumatic brain injury (TBI) is a major public health problem. Caused by external mechanical forces, a major characteristic of TBI is the shearing of axons across the white matter, which causes structural connectivity disruptions between b…
View article: Treatment Trials in Disorders of Consciousness: Challenges and Future Directions
Treatment Trials in Disorders of Consciousness: Challenges and Future Directions Open
The evidence base supporting treatment interventions for patients with disorders of consciousness is limited, and rigorous treatment trials are needed to guide future management of this complex patient population. There are many potential …
View article: Improving the Precision of the Glasgow Outcome Scale-Extended Using Item Response Theory: A TRACK-TBI Study
Improving the Precision of the Glasgow Outcome Scale-Extended Using Item Response Theory: A TRACK-TBI Study Open
The Glasgow Outcome Scale-Extended (GOSE) is a functional outcome measure intended to place individuals with traumatic brain injury (TBI) into one of eight broad levels of injury-related disability. This simplicity is not always optimal, p…
View article: Group Collaborator Supplement Added
Group Collaborator Supplement Added Open
Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Ischemic Stroke
View article: Comparing Ways to Identify Sleep Apnea in People with Traumatic Brain Injury during Inpatient Rehabilitation
Comparing Ways to Identify Sleep Apnea in People with Traumatic Brain Injury during Inpatient Rehabilitation Open
View article: Error in Figure
Error in Figure Open
Gustavo Luna, MSc; Peter Alping, MD; Joachim Burman, MD, PhD; Katharina Fink, MD, PhD; Anna Fogdell-Hahn, PhD; Martin Gunnarsson, MD, PhD; Jan Hillert, MD, PhD; Annette Langer-Gould, MD, PhD; Jan Lycke, MD, PhD; Petra Nilsson, MD, PhD; Jon…
View article: Voice Therapy According to the Rehabilitation Treatment Specification System: Expert Consensus Ingredients and Targets
Voice Therapy According to the Rehabilitation Treatment Specification System: Expert Consensus Ingredients and Targets Open
Purpose Clinical trials have demonstrated that standardized voice treatment programs are effective for some patients, but identifying the unique individual treatment ingredients specifically responsible for observed improvements remains el…
View article: Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness
Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness Open
View article: Therapies to Restore Consciousness in Patients with Severe Brain Injuries: A Gap Analysis and Future Directions
Therapies to Restore Consciousness in Patients with Severe Brain Injuries: A Gap Analysis and Future Directions Open
Background/Objective For patients with disorders of consciousness (DoC) and their families, the search for new therapies has been a source of hope and frustration. Almost all clinical trials in patients with DoC have been limited by small …
View article: Relationship between transdiagnostic dimensions of psychopathology and traumatic brain injury (TBI): A TRACK-TBI study.
Relationship between transdiagnostic dimensions of psychopathology and traumatic brain injury (TBI): A TRACK-TBI study. Open
Neuropsychiatric symptoms are common, comorbid, and often disabling for patients with traumatic brain injury (TBI). Identifying transdiagnostic symptom dimensions post-TBI may help overcome limitations of traditional psychiatric diagnoses …
View article: Building a theoretical foundation for cognitive rehabilitation
Building a theoretical foundation for cognitive rehabilitation Open
This scientific commentary refers to ‘A randomized clinical trial of plasticity-based cognitive training in mild traumatic brain injury’ by Mahncke et al. (doi:10.1093/brain/awab202).