John Wiersch
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View article: Bone-marrow derived cells do not contribute to new beta-cells in the inflamed pancreas
Bone-marrow derived cells do not contribute to new beta-cells in the inflamed pancreas Open
The contribution of bone-marrow derived cells (BMCs) to a newly formed beta-cell population in adults is controversial. Previous studies have only used models of bone marrow transplantation from sex-mismatched donors (or other models of ge…
View article: Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation
Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation Open
Although islet transplantation is an effective treatment for severe diabetes, its broad application is greatly limited due to a shortage of donor islets. Suppression of TGFβ receptor signaling in β-cells has been shown to increase β-cell p…