John Wink
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View article: Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site
Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site Open
Beta-cell replacement therapy is an effective means to restore glucose homeostasis in select humans with autoimmune diabetes. The scarcity of "healthy" human donor pancreata restricts the broader application of this effective curative ther…
View article: Long-term function and optimization of mouse and human islet transplantation in the subcutaneous device-less site
Long-term function and optimization of mouse and human islet transplantation in the subcutaneous device-less site Open
Clinical islet transplantation has routinely been demonstrated to be an efficacious means of restoring glycemic control in select patients with autoimmune diabetes. Notwithstanding marked progress and improvements, the broad-spectrum appli…
View article: Reparixin, a CXCR1/2 inhibitor in islet allotransplantation
Reparixin, a CXCR1/2 inhibitor in islet allotransplantation Open
Quality of life in Type 1 diabetic patients may be improved with islet transplantation, but lifelong immunosuppression is required to prevent rejection. Allo-immune response is a key player in graft dysfunction and although the adaptive im…