John H. Zhang
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View article: Myosteatosis as an independent predictor for all-cause and cardiac mortality in initial-dialysis patients: a multicenter, retrospective cohort study
Myosteatosis as an independent predictor for all-cause and cardiac mortality in initial-dialysis patients: a multicenter, retrospective cohort study Open
Background Myosteatosis is associated with adverse prognosis in diseases. We aimed to establish thresholds for myosteatosis, assess its association with all-cause and cardiac mortality in initial dialysis patients, and construct a myosteat…
View article: Mechanism by which 24-week different-volume high-intensity interval training ameliorates renal fibrosis in naturally aging rats via regulating the TGF-β1/Smad pathway
Mechanism by which 24-week different-volume high-intensity interval training ameliorates renal fibrosis in naturally aging rats via regulating the TGF-β1/Smad pathway Open
24-week HIIT intervention can effectively delay the decline of renal function and the progression of renal fibrosis in naturally aging rats. Its protective effect may be associated with inhibiting the overactivation of the TGF-β1/Smad sign…
View article: [Corrigendum] LSKL peptide alleviates subarachnoid fibrosis and hydrocephalus by inhibiting TSP1‑mediated TGF‑β1 signaling activity following subarachnoid hemorrhage in rats
[Corrigendum] LSKL peptide alleviates subarachnoid fibrosis and hydrocephalus by inhibiting TSP1‑mediated TGF‑β1 signaling activity following subarachnoid hemorrhage in rats Open
[This corrects the article DOI: 10.3892/etm.2016.3640.].
View article: Link between heart failure and stroke: a comprehensive review
Link between heart failure and stroke: a comprehensive review Open
Heart failure and stroke are two major cardiovascular conditions that significantly contribute to morbidity and mortality worldwide.1 While the link between heart failure and ischemic stroke is well understood, the relationship between hea…
View article: The role of exercise in enhancing brain and cerebrovascular health via the bone–brain axis: implications for surgical and clinical interventions
The role of exercise in enhancing brain and cerebrovascular health via the bone–brain axis: implications for surgical and clinical interventions Open
The bone–brain axis constitutes an interactive bidirectional signaling network integrating skeletal, neural, and muscular systems, serving critical functions across both normal physiological operations and disease mechanisms. Exercise, a n…
View article: CD8+GZMK+CD27+CCR7+ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells
CD8+GZMK+CD27+CCR7+ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells Open
Splenic sympathetic activity critically modulates peripheral immunity after ischemic stroke, thus intervention in spleen sympathetic activity represents a promising therapeutic strategy for stroke. However, the mechanisms underlying spleen…
View article: P-585 Experiences of a comprehensive prenatal cfDNA screening for chromosome aneuploidies, microdeletions and monogenic conditions in general pregnancy population
P-585 Experiences of a comprehensive prenatal cfDNA screening for chromosome aneuploidies, microdeletions and monogenic conditions in general pregnancy population Open
Study question How is the performance of coordinative allele-aware target enrichment sequencing (COATE-seq) cfDNA screening panel (KNOVA) in general pregnancy population Summary answer The COATE-seq cfDNA screening panel (KNOVA) achieved h…
View article: Gamma knife radiosurgery for a rare Rosette-forming glioneuronal tumor in the brainstem region: A case report and literature review
Gamma knife radiosurgery for a rare Rosette-forming glioneuronal tumor in the brainstem region: A case report and literature review Open
Rationale: Rosette-forming glioneuronal tumor (RGNT) is a rare primary nervous system tumor, with limited treatment guidelines due to its rarity, especially in the brainstem. This report presents a unique case of brainstem RGNT treated wit…
View article: Melatonin promotes tendon-derived stem cells differentiation and inhibits oxidative stress in trauma-induced heterotopic ossification
Melatonin promotes tendon-derived stem cells differentiation and inhibits oxidative stress in trauma-induced heterotopic ossification Open
Background: Heterotopic ossification (HO) is a common complication of muscle and tendon injury, but its underlying mechanism is currently unclear. Melatonin (MT), a hormone mainly secreted by the pineal gland, plays a key role in the patho…
View article: Bioactivity and Neuroprotective Effects of Extra Virgin Olive Oil in a Mouse Model of Cerebral Ischemia: An In Vitro and In Vivo Study
Bioactivity and Neuroprotective Effects of Extra Virgin Olive Oil in a Mouse Model of Cerebral Ischemia: An In Vitro and In Vivo Study Open
Cerebral ischemia is a pathological condition characterized by complete blood and oxygen supply deprivation to neuronal tissue. The ischemic brain compensates for the rapid decline in ATP levels by increasing the anaerobic glycolysis rate,…
View article: Piezoelectric hydrogel with self-powered biomechanical stimulation enhances bone regeneration
Piezoelectric hydrogel with self-powered biomechanical stimulation enhances bone regeneration Open
Large bone defect healing remains a challenge in current clinical treatment, which suggests the need for functional bone repair materials. Piezoelectric materials can generate electrical stimulation under mechanical stress to improve the t…
View article: Enhanced Spatial Transcriptomics Analysis of Mouse Lung Tissues Reveals Cell-Specific Gene Expression Changes Associated with Pulmonary Hypertension
Enhanced Spatial Transcriptomics Analysis of Mouse Lung Tissues Reveals Cell-Specific Gene Expression Changes Associated with Pulmonary Hypertension Open
Spatial transcriptomics technologies have emerged as powerful tools for understanding cellular identity and function within the natural spatial context of tissues. Traditional transcriptomics techniques, such as bulk and single-cell RNA se…
View article: IL2RB and TUBA1B are Potential Targets of Music Therapy for Alzheimer’s Disease and Cognitive Impairment
IL2RB and TUBA1B are Potential Targets of Music Therapy for Alzheimer’s Disease and Cognitive Impairment Open
Objective: This study examined the complex interactions among differential gene expression, immune responses, therapy-associated genes in Alzheimer’s disease (AD), and cognitive impairment, with a distinct focus on the integration of music…