Johnathan D. Tune
YOU?
Author Swipe
View article: Immersion‐Based Clearing and Autofluorescence Quenching in Myocardial Tissue
Immersion‐Based Clearing and Autofluorescence Quenching in Myocardial Tissue Open
Objective Recent innovations in optical microscopy and tissue preparation permit 3D visualization of complex microvascular networks. Tissue clearing techniques improve light penetration and extend imaging depth. Typically, perfusion‐based …
View article: Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration
Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration Open
The Notch intercellular signaling pathways play significant roles in cardiovascular development, disease, and regeneration through modulating cardiovascular cell specification, proliferation, differentiation, and morphogenesis. The dysregu…
View article: Multiscale model of the physiological control of myocardial perfusion to delineate putative metabolic feedback mechanisms
Multiscale model of the physiological control of myocardial perfusion to delineate putative metabolic feedback mechanisms Open
Coronary blood flow is tightly regulated to ensure that myocardial oxygen delivery meets local metabolic demand via the concurrent action of myogenic, neural, and metabolic mechanisms. While several competing hypotheses exist, the specific…
View article: Distinct hemodynamic responses to (pyr)apelin-13 in large animal models
Distinct hemodynamic responses to (pyr)apelin-13 in large animal models Open
This study tested the hypothesis that (pyr)apelin-13 dose-dependently augments myocardial contractility and coronary blood flow, irrespective of changes in systemic hemodynamics. Acute effects of intravenous (pyr)apelin-13 administration (…
View article: Experimental animal models of coronary microvascular dysfunction
Experimental animal models of coronary microvascular dysfunction Open
Coronary microvascular dysfunction (CMD) is commonly present in patients with metabolic derangements and is increasingly recognized as an important contributor to myocardial ischaemia, both in the presence and absence of epicardial coronar…
View article: Disentangling the Gordian knot of local metabolic control of coronary blood flow
Disentangling the Gordian knot of local metabolic control of coronary blood flow Open
Recognition that coronary blood flow is tightly coupled with myocardial metabolism has been appreciated for well over half a century. However, exactly how coronary microvascular resistance is tightly coupled with myocardial oxygen consumpt…
View article: Obesity decreases the contribution of Kv channels to hypoxic coronary vasodilation
Obesity decreases the contribution of Kv channels to hypoxic coronary vasodilation Open
Background and Hypothesis: Our group previously demonstrated that reductions in the functional expression of voltage-dependent K+ (Kv) channels contribute to impaired metabolic control of coronary blood flow in the setting of obesity. This…
View article: Inhibition of Type 2 Sodium-Glucose Transporters and Na+/H+ Exchanger-1 produces similar cardioprotective effects in response to ischemiareperfusion injury
Inhibition of Type 2 Sodium-Glucose Transporters and Na+/H+ Exchanger-1 produces similar cardioprotective effects in response to ischemiareperfusion injury Open
Background and Hypothesis: Recent studies indicate that inhibition of Type 2 Sodium-Glucose Transporters (SGLT2i) augments diastolic filling volume and mitigates myocardial ischemic injury. This study tested the hypothesis that inhibition …
View article: Modulation of Myocardial Oxygen Delivery in Response to Isovolemic Hemodilution
Modulation of Myocardial Oxygen Delivery in Response to Isovolemic Hemodilution Open
Background and Hypothesis: Prior studies have established that progressive increases in coronary blood flow are sufficient to maintain myocardial oxygen delivery in response to reductions in arterial oxygenation. However, the precise mecha…
View article: Cardiovascular Effects of Sodium Glucose Cotransporter-2 (SGLT-2) Inhibition in the Setting of Ischemia/Reperfusion Injury
Cardiovascular Effects of Sodium Glucose Cotransporter-2 (SGLT-2) Inhibition in the Setting of Ischemia/Reperfusion Injury Open
Background and Hypothesis: Recent evidence indicates that sodium glucose cotransporter-2 inhibitors (SGLT2i) significantly reduce the incidence of major adverse cardiovascular events in high risk patients. However, the specific effects of …
View article: Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection vs. Insulin Alone in Type 2 Diabetes
Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection vs. Insulin Alone in Type 2 Diabetes Open
Context It is unclear if effects of glucagon-like peptide-1 (GLP-1) and clinically available GLP-1 agonists on the heart occur at clinical doses in humans, possibly contributing to reduced cardiovascular disease risk. Objective To determin…
View article: Small-Group Activity to Reinforce the Impact of Valvular Defects and Heart Failure on Cardiac Pressure-Volume Relationships
Small-Group Activity to Reinforce the Impact of Valvular Defects and Heart Failure on Cardiac Pressure-Volume Relationships Open
Small group, active learning exercises benefited student learning by providing a framework for analysis, synthesis, and application of clinically relevant cardiac physiology concepts.
View article: ROCK as a molecular bond connecting coronary microvascular and cardiac remodelling
ROCK as a molecular bond connecting coronary microvascular and cardiac remodelling Open
__This editorial refers to ‘Enhanced endothelin-1/Rho-kinase signaling and coronarymicrovascular dysfunction in hypertensive myocardial hypertrophy’ by S.H. Tsai et al., pp. 1329–1337.__
Communication between cardiomyocytes and the co…
View article: Glucagon-Like Peptide 1 Receptor Activation Augments Cardiac Output and Improves Cardiac Efficiency in Obese Swine After Myocardial Infarction
Glucagon-Like Peptide 1 Receptor Activation Augments Cardiac Output and Improves Cardiac Efficiency in Obese Swine After Myocardial Infarction Open
This study tested the hypothesis that glucagon-like peptide 1 (GLP-1) therapies improve cardiac contractile function at rest and in response to adrenergic stimulation in obese swine after myocardial infarction. Obese Ossabaw swine were sub…
View article: Regulation of Coronary Blood Flow
Regulation of Coronary Blood Flow Open
The heart is uniquely responsible for providing its own blood supply through the coronary circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of dedicated research, is understood to be dictated through…
View article: Regulation of Coronary Blood Flow
Regulation of Coronary Blood Flow Open
The heart is uniquely responsible for providing its own blood supply through the coronary circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of dedicated research, is understood to be dictated through…
View article: Mutual reinforcement of pathophysiological host‐microbe interactions in intestinal stasis models
Mutual reinforcement of pathophysiological host‐microbe interactions in intestinal stasis models Open
Chronic diseases arise when there is mutual reinforcement of pathophysiological processes that cause an aberrant steady state. Such a sequence of events may underlie chronic constipation, which has been associated with dysbiosis of the gut…
View article: Repeat cross-sectional data on the progression of the metabolic syndrome in Ossabaw miniature swine
Repeat cross-sectional data on the progression of the metabolic syndrome in Ossabaw miniature swine Open
Ossabaw miniature swine were fed an excess calorie, atherogenic diet for 6, 9, or 12 months. Increased body weight, hypertension, and increased plasma cholesterol and triglycerides are described in Table 1. For more detailed interpretation…