Johnny Millar
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View article: Beta-lactam antibiotic administration in critically ill children with sepsis: an international survey of current practice
Beta-lactam antibiotic administration in critically ill children with sepsis: an international survey of current practice Open
Objective To assess current international practices and perceptions regarding beta-lactam antibiotic administration in critically ill children with sepsis. Design, setting, and participants An electronic survey was distributed among physic…
View article: Social determinants of health and intensive care unit admission rates and outcomes for children, Australia, 2013–2020: analysis of national registry data
Social determinants of health and intensive care unit admission rates and outcomes for children, Australia, 2013–2020: analysis of national registry data Open
Objectives To investigate the influence of non‐medical social determinants of health on rates of admission and outcomes for children admitted to intensive care units (ICUs) in Australia. Study design Retrospective cohort study; analysis of…
View article: Neurodevelopmental Outcomes After Nitric Oxide During Cardiopulmonary Bypass for Open Heart Surgery
Neurodevelopmental Outcomes After Nitric Oxide During Cardiopulmonary Bypass for Open Heart Surgery Open
Importance Children with congenital heart defects who undergo cardiopulmonary bypass (CPB) surgery are at risk for delayed or impaired neurodevelopmental outcomes. Nitric oxide (NO) added to the CPB oxygenator may reduce systemic inflammat…
View article: Stratified analyses refine association between TLR7 rare variants and severe COVID-19
Stratified analyses refine association between TLR7 rare variants and severe COVID-19 Open
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence…
View article: Fluid management and active fluid removal practices: a global survey of paediatric critical care physicians
Fluid management and active fluid removal practices: a global survey of paediatric critical care physicians Open
Aims Fluid accumulation (FA) in critically ill children is associated with poor clinical outcomes. While conservative fluid management has been proposed, evidence to guide practice is scarce. We surveyed paediatric critical care (PCC) phys…
View article: Potential benefits of prenatal diagnosis of TGA in Australia may be outweighed by the adverse effects of earlier delivery: likely causation and potential solutions
Potential benefits of prenatal diagnosis of TGA in Australia may be outweighed by the adverse effects of earlier delivery: likely causation and potential solutions Open
Objective Prenatal diagnosis of transposition of great arteries (TGA) is expected to improve postoperative outcomes after neonatal arterial switch operation (ASO); however, published reports give conflicting results. We aimed to determine …
View article: Modelling of intensive care unit (ICU) length of stay as a quality measure: a problematic exercise
Modelling of intensive care unit (ICU) length of stay as a quality measure: a problematic exercise Open
Background Intensive care unit (ICU) length of stay (LOS) and the risk adjusted equivalent (RALOS) have been used as quality metrics. The latter measures entail either ratio or difference formulations or ICU random effects (RE), which have…
View article: Machine learning to predict poor school performance in paediatric survivors of intensive care: a population-based cohort study
Machine learning to predict poor school performance in paediatric survivors of intensive care: a population-based cohort study Open
A machine learning model using data available at time of ICU discharge predicted failure to meet minimum educational requirements at school age. Implementation of this prediction tool could assist in prioritizing patients for follow-up and…
View article: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 Open
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown 1 to be highly efficient for discovery of genetic associations 2 . Despite the advanced stage of illness at presentation,…
View article: Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery
Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery Open
anzctr.org.au Identifier: ACTRN12617000821392.
View article: Educational Outcomes of Childhood Survivors of Critical Illness-A Population-Based Linkage Study
Educational Outcomes of Childhood Survivors of Critical Illness-A Population-Based Linkage Study Open
OBJECTIVES Major postintensive care sequelae affect up to one in three adult survivors of critical illness. Large cohorts on educational outcomes after pediatric intensive care are lacking. We assessed primary school educational outcomes i…
View article: Admissions of Children and Adolescents With Deliberate Self-harm to Intensive Care During the SARS-CoV-2 Outbreak in Australia
Admissions of Children and Adolescents With Deliberate Self-harm to Intensive Care During the SARS-CoV-2 Outbreak in Australia Open
This cohort study found that the coronavirus pandemic in Australia was associated with a significant increase in admissions of children and adolescents to intensive care with DSH.
View article: Increasing ICU capacity to accommodate higher demand during the COVID‐19 pandemic
Increasing ICU capacity to accommodate higher demand during the COVID‐19 pandemic Open
The number of currently available staffed ICU beds is lower than in 2020. Equipment shortfalls have been remediated, with sufficient ventilators to equip every ICU bed. ICU capacity can be increased in response to demand, but is constraine…
View article: Dexmedetomidine Sedation in Mechanically Ventilated Critically Ill Children: A Pilot Randomized Controlled Trial
Dexmedetomidine Sedation in Mechanically Ventilated Critically Ill Children: A Pilot Randomized Controlled Trial Open
Objectives: To assess the feasibility, safety, and efficacy of a sedation protocol using dexmedetomidine as the primary sedative in mechanically ventilated critically ill children. Design: Open-label, pilot, prospective, multicenter, rando…
View article: Surge capacity of intensive care units in case of acute increase in demand caused by <scp>COVID</scp> ‐19 in Australia
Surge capacity of intensive care units in case of acute increase in demand caused by <span>COVID</span> ‐19 in Australia Open
The directors of Australian ICUs report that intensive care bed capacity could be near tripled in response to the expected increase in demand caused by COVID-19. But maximal surge in bed numbers could be hampered by a shortfall in invasive…
View article: RACHS‐ANZ: A Modified Risk Adjustment in Congenital Heart Surgery Model for Outcome Surveillance in Australia and New Zealand
RACHS‐ANZ: A Modified Risk Adjustment in Congenital Heart Surgery Model for Outcome Surveillance in Australia and New Zealand Open
Background Outcomes for pediatric cardiac surgery are commonly reported from international databases compiled from voluntary data submissions. Surgical outcomes for all children in a country or region are less commonly reported. We aimed t…
View article: Patterns of organ donation in children in Australia and New Zealand
Patterns of organ donation in children in Australia and New Zealand Open
Paediatric OD rates have not changed over time but are comparable to adults when expressed as a percentage of ICU deaths. Paediatric DCD has increased significantly over time.
View article: Inter-hospital transport of the child with critical cardiac disease
Inter-hospital transport of the child with critical cardiac disease Open
Centralisation of services such as cardiology, cardiac surgery, and intensive care in many parts of the world has resulted in the need to safely transport children with critical cardiac disease from local hospitals to specialist centres fo…
View article: Ventricular assist device support in patients with single ventricles: the Melbourne experience†
Ventricular assist device support in patients with single ventricles: the Melbourne experience† Open
VAD support in patients with a single ventricle has a high hospital mortality, with 1 of 3 patients surviving to discharge. Systemic VAD support is likely futile in the setting of early Fontan failure or when re-initiation of support is re…