Johnny Zigmond
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HSP90α and KLK6 Coregulate Stress-Induced Prostate Cancer Cell Motility Open
Prostate cancer (PCa) metastasis is reliant on the activity of proteases, such as matrix metalloproteinase-2 (MMP-2). While increased extracellular heat shock protein 90α (eHSP90α) has been linked to increased MMP-2 activity, this has not …
HSP90α and KLK6 Co-Regulate Stress-Induced Prostate Cancer Cell Motility Open
Background Prostate cancer (PCa) metastasis is reliant on the activity of proteases, such as matrix metalloproteinase-2 (MMP-2). While increased extracellular heat shock protein 90α (eHSP90α) has been linked to increased MMP-2 activity, th…
A Building Block Approach for the Total Synthesis of YM‐385781 Open
YM‐254890 and FR900359 are potent and selective inhibitors of the Gq/11‐signaling pathway. As such, they have been attractive targets for both synthesis and biological studies. Yet in spite of this effort, a versatile synthetic approach to…