Jianzhong Liu
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View article: Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) – possible combination use
Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) – possible combination use Open
Aging is a complex biological process characterized by the gradual deterioration of cellular functions, leading to an increased susceptibility to chronic diseases. In the search for interventions to promote healthy aging and extend lifespa…
View article: A review on coconut testa: Nutritional attributes, physical properties, biological activities, and product innovation
A review on coconut testa: Nutritional attributes, physical properties, biological activities, and product innovation Open
Coconut testa (CT) is the brown color outer skin of the coconut flesh, a by-product of the coconut processing industry. It is often discarded or used to extract low-grade oil and the remaining residue is utilized for animal feed preparatio…
View article: Evaluation of the antidiabetic effects of green lipped mussel oil and its combination with low molecular weight fucoidan extracted from Undaria pinnatifida
Evaluation of the antidiabetic effects of green lipped mussel oil and its combination with low molecular weight fucoidan extracted from Undaria pinnatifida Open
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and insulin resistance, which is closely associated with obesity and inflammation. This highlights the need for safe anti-diabetic supplements that enhance insulin sensitivi…
View article: Advancements in the understanding of mechanisms of the IL-6 family in relation to metabolic-associated fatty liver disease
Advancements in the understanding of mechanisms of the IL-6 family in relation to metabolic-associated fatty liver disease Open
As lifestyle patterns change, the rates of type 2 diabetes and obesity are increasing together, leading to an increase in metabolic-associated fatty liver disease (MAFLD), now recognized as the most frequently occurring liver disease globa…
View article: CDA-SimBoost: A Unified Framework Bridging Real Data and Simulation for Infrastructure-Based CDA Systems
CDA-SimBoost: A Unified Framework Bridging Real Data and Simulation for Infrastructure-Based CDA Systems Open
Cooperative Driving Automation (CDA) has garnered increasing research attention, yet the role of intelligent infrastructure remains insufficiently explored. Existing solutions offer limited support for addressing long-tail challenges, real…
View article: A bibliometric analysis of metabolic dysfunction-associated steatotic liver disease in children from 2004 to 2024
A bibliometric analysis of metabolic dysfunction-associated steatotic liver disease in children from 2004 to 2024 Open
Background Metabolic dysfunction-associated steatotic liver disease (MASLD), once known as Non-alcoholic fatty liver disease, impacts between 3% and 10% of children and adolescents globally, as well as nearly one-third of obsessed boys and…
View article: InSPE: Rapid Evaluation of Heterogeneous Multi-Modal Infrastructure Sensor Placement
InSPE: Rapid Evaluation of Heterogeneous Multi-Modal Infrastructure Sensor Placement Open
Infrastructure sensing is vital for traffic monitoring at safety hotspots (e.g., intersections) and serves as the backbone of cooperative perception in autonomous driving. While vehicle sensing has been extensively studied, infrastructure …
View article: Ethics in Sartre's Existentialist Drama: A Study of The Flies and Men Without Shadows
Ethics in Sartre's Existentialist Drama: A Study of The Flies and Men Without Shadows Open
In todays diverse and rapidly changing society, traditional values and ethical perspectives are under challenge. The pressure of social competition has led many to experience a sense of emptiness and a loss of meaning in life. Sartres exis…
View article: P1232 A Novel Inflammatory Bowel Disease Registry Powered by Artificial Intelligence and Natural Language Processing
P1232 A Novel Inflammatory Bowel Disease Registry Powered by Artificial Intelligence and Natural Language Processing Open
Background Accurate data registries may assist clinicians and researchers to gain insights into inflammatory bowel disease(IBD) and provide opportunities to improve overall patient care. However, most data registries are limited by the amo…
View article: Efficient Synthesis of γ-Aminobutyric Acid from Monosodium Glutamate Using an Engineered Glutamate Decarboxylase Active at a Neutral pH
Efficient Synthesis of γ-Aminobutyric Acid from Monosodium Glutamate Using an Engineered Glutamate Decarboxylase Active at a Neutral pH Open
The efficient production of γ-aminobutyric acid (GABA) at a neutral pH remains a challenge due to the pH sensitivity of glutamate decarboxylase (GAD) enzymes. Our study addressed this limitation by identifying and engineering GAD enzymes w…
View article: V2XPnP: Vehicle-to-Everything Spatio-Temporal Fusion for Multi-Agent Perception and Prediction
V2XPnP: Vehicle-to-Everything Spatio-Temporal Fusion for Multi-Agent Perception and Prediction Open
Vehicle-to-everything (V2X) technologies offer a promising paradigm to mitigate the limitations of constrained observability in single-vehicle systems. Prior work primarily focuses on single-frame cooperative perception, which fuses agents…
View article: Evaluating the quality of multiple‐choice question pilot database: A global educator‐created tool for concept‐based pharmacology learning
Evaluating the quality of multiple‐choice question pilot database: A global educator‐created tool for concept‐based pharmacology learning Open
The Core Concepts of Pharmacology (CCP) initiative is developing educational resources to transform pharmacology education into a concept‐based approach. This study evaluated the quality of global educator‐created MCQs in generating items …
View article: Small molecule tyrosine kinase inhibitors approved for systemic therapy of advanced hepatocellular carcinoma: recent advances and future perspectives
Small molecule tyrosine kinase inhibitors approved for systemic therapy of advanced hepatocellular carcinoma: recent advances and future perspectives Open
Liver cancer is the sixth most commonly diagnosed cancer and the third leading cause of cancer death in the world, and hepatocellular carcinoma (HCC) is the most common form of liver cancer. More than half of the HCC patients are diagnosed…
View article: Malignancy in the Upadacitinib Clinical Trials for Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Non-radiographic Axial Spondyloarthritis
Malignancy in the Upadacitinib Clinical Trials for Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Non-radiographic Axial Spondyloarthritis Open
ClinicaTrials.gov identifier: NCT02706873, NCT02675426, NCT02629159, NCT02706951, NCT02706847, NCT03086343, NCT03104400, NCT03104374, NCT03178487, and NCT04169373.
View article: Use of body weight-adjusted FEV1/FVC as an index to predict the risk of sarcopenia among elderly people in the community
Use of body weight-adjusted FEV1/FVC as an index to predict the risk of sarcopenia among elderly people in the community Open
Background The quality and function of skeletal muscle decrease with aging in humans. Meanwhile, sarcopenia leads to increased fat mass and decreased muscle mass in the elderly. Furthermore, sarcopenia results in decreased respiratory musc…
View article: Upadacitinib treatment withdrawal and retreatment in patients with moderate‐to‐severe atopic dermatitis: Results from a phase 2b, randomized, controlled trial
Upadacitinib treatment withdrawal and retreatment in patients with moderate‐to‐severe atopic dermatitis: Results from a phase 2b, randomized, controlled trial Open
Background Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritic eczematous lesions. The effect of treatment withdrawal after response to upadacitinib oral treatment is not fully characterized. Objectives …
View article: A Survey of Industry Perceptions of Facilitated Regulatory Pathways in Drug Development in Australia
A Survey of Industry Perceptions of Facilitated Regulatory Pathways in Drug Development in Australia Open
While the FRPs have been an important and positive development in the Australian regulatory landscape, there remain opportunities for further improvements, some of which have been highlighted by this study and may help inform future regula…
View article: Gemcitabine‑fucoxanthin combination in human pancreatic cancer cells
Gemcitabine‑fucoxanthin combination in human pancreatic cancer cells Open
Gemcitabine is a chemotherapeutic agent for pancreatic cancer treatment. It has also been demonstrated to inhibit human pancreatic cancer cell lines, MIA PaCa-2 and PANC-1. The aim of the present study was to investigate the suppressive ef…
View article: Additional file 2 of Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference
Additional file 2 of Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference Open
Additional file 2: Table S1 Antibodies used in this study. Table S2 Primers for RT-qPCR.
View article: P220 Long-term safety profile of upadacitinib in patients with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis
P220 Long-term safety profile of upadacitinib in patients with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis Open
Background/Aims The objective of this analysis is to describe the long-term safety profile of upadacitinib (UPA) across rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) from the SELECT clinical program.…
View article: Benefit–Risk Analysis of Upadacitinib Compared with Adalimumab in the Treatment of Patients with Moderate-to-Severe Rheumatoid Arthritis
Benefit–Risk Analysis of Upadacitinib Compared with Adalimumab in the Treatment of Patients with Moderate-to-Severe Rheumatoid Arthritis Open
In patients with active RA despite MTX use, UPA demonstrated an incremental achievement of clinical outcomes compared to ADA together with a similar profile of AESIs with ADA (with the exception of herpes zoster).
View article: Chronic stroke sensorimotor impairment is related to smaller hippocampal volumes: An ENIGMA analysis
Chronic stroke sensorimotor impairment is related to smaller hippocampal volumes: An ENIGMA analysis Open
Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is involved in sensorimotor behavior but has not been widely studied within the context of post-stroke upper limb sensorimotor impairme…
View article: [Evaluation on monitoring effect of the electronic vaccine vial monitor label].
[Evaluation on monitoring effect of the electronic vaccine vial monitor label]. Open
The cold chain safety of vaccines is a global issue. The electronic vaccine vial monitor (eVVM) label can monitor the temperature of vaccines in real time and provide "early warning" prompts. In order to comprehensively evaluate the monito…
View article: Rapid lateral flow immunoassay for the fluorescence detection of SARS-CoV-2 RNA
Rapid lateral flow immunoassay for the fluorescence detection of SARS-CoV-2 RNA Open
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need for rapid and accurate nucleic acid detection at the point of care. Here, we report an amplification-free nucleic acid immunoassay, implemented on a lateral flow str…