Explanipedia

Dose, dose rate and split dose impacts murine skin responses following photon FLASH irradiation Open

Kathryn H. Brown, Mihaela Ghita, Malachy P McIvor, Mark P McDowell, Owen McLaughlin , et al. · 2025

These results demonstrate it is feasible to deliver photon FLASH exposures with sparing consistent with observations from previous studies using proton and electron beams. Dose, average dose rate and beam structure are key parameters that …

Focusing of X-ray free-electron laser pulses using multilayer Laue lenses Open

Margarita Zakharova, John Wong, J. Lukas Dresselhaus, Mauro Prasciolu, Holger Fleckenstein , et al. · 2025

Physics Materials science

Achieving the highest possible intensities of pulses at X-ray free-electron laser (XFEL) facilities entails focusing the X-ray beam to the smallest possible dimensions. Multilayer Laue lenses are volume diffractive optics that hold promise…

Enhancing fieldwork readiness in occupational therapy students with generative AI Open

Tara Mansour, John Wong · 2024

Psychology Medicine Computer science

The rapid integration of artificial intelligence (AI) into health professions education is revolutionizing traditional teaching methodologies and enhancing learning experiences. This study explores the use of generative AI to aid occupatio…

Effect of Ultrahigh Dose Rate on Biomolecular Radiation Damage Open

Daniel Sforza, Fred Bunz, John Wong, Devin Miles, Amitava Adhikary , et al. · 2024

Chemistry Biology Physics

Dose rate is one of the important parameters in radiation-induced biomolecular damage. The effects of dose rate have been known to modify radiation toxicity in biological systems. The rate and extent of sublethal DNA damage (e.g., base dam…

Convergent-beam attosecond X-ray crystallography Open

Henry N. Chapman, Chufeng Li, S. Bajt, Mansi Butola, J. Lukas Dresselhaus , et al. · 2024

Physics Materials science

Sub-angstrom spatial resolution of electron density coupled with sub-femtosecond temporal resolution is required to directly observe the dynamics of the electronic structure of a molecule after photoinitiation or some other ultrafast pertu…

Acupuncture and Escitalopram for Treating Major Depression Clinical Study (AE-TMDCS): protocol for a factorial randomised controlled trial Open

Kaiqi Yang, Sagun Tiwari, Dezhi Liu, Qinfeng Xu, Lili Qi , et al. · 2024

Medicine Economics

Introduction Major depressive disorder (MDD), the second leading cause of disability globally, is considered to be associated with a consequent deterioration in the quality of life and can lead to a major economic burden on medical service…

Examining fundamental nursing textbooks for inclusivity and exclusivity content: A directed qualitative content analysis Open

Eleonor Pusey‐Reid, Cassandra P. Mombrun, Mirza J. Lugo‐Neris, Jean M. Bernhardt, Kevin Berner , et al. · 2024

Sociology Medicine Psychology

The study highlights inclusive language in fundamental nursing textbooks but reveals significant exclusive language perpetuating negative generalizations, including marginalized identities and race prevalence without context. This content …

A universal bioluminescence tomography system for pre-clinical image-guided radiotherapy research Open

Zhishen Tong, Zijian Deng, Xiangkun Xu, Ciara Newman, Xun Jia , et al. · 2024

Computer science Medicine Biology

CBCT-guided small animal irradiators encounter challenges in localizing soft-tissue targets due to low imaging contrast. Bioluminescence tomography (BLT) offers a promising solution, but they have largely remained in laboratorial developme…

Real-Time Gated Proton Therapy: Commissioning and Clinical Workflow for the Hitachi System Open

Hao Chen, Emile Gogineni, Yilin Cao, John Wong, Curtiland Deville , et al. · 2024

Computer science Medicine Political science

Real-time gated proton therapy with the Hitachi System has been fully investigated and commissioned for clinical application. RGPT can provide advanced and reliable real-time image guidance to enhance patient safety and inform important tr…

Electroacupuncture Enhances the Functional Connectivity of Limbic System to Neocortex in the 5xFAD Mouse Model of Alzheimer's Disease Open

Mingzhu Xu, Run Lin, Huaneng Wen, Yixiao Wang, John Wong , et al. · 2024

Psychology Medicine

Our previous study revealed that acupuncture may exhibit therapeutic effects on Alzheimer's disease (AD) through the activation of metabolism in memory-related brain regions. However, the underlying functional mechanism remains poorly unde…

Substandard housing and the risk of COVID-19 infection and disease severity: A retrospective cohort study Open

Katharine Robb, Rowana Ahmed, John Wong, Elissa Ladd, J. de Jong · 2024

Medicine Sociology

In this study we examine associations between substandard housing and the risk of COVID-19 infection and severity during the first year of the pandemic by linking individual-level housing and clinical datasets. Residents of Chelsea, Massac…

Characterization of a commercial bioluminescence tomography‐guided system for pre‐clinical radiation research Open

Xiangkun Xu, Zijian Deng, Daniel Sforza, Zhishen Tong, Yu‐Pei Tseng , et al. · 2023

Medicine Biology

Background Widely used Cone‐beam computed tomography (CBCT)‐guided irradiators have limitations in localizing soft tissue targets growing in a low‐contrast environment. This hinders small animal irradiators achieving precise focal irradiat…

Representation of dark skin tones in foundational nursing textbooks: An image analysis Open

Eleonor Pusey‐Reid, Lisa Quinn, John Wong, Andrea Wucherpfennig · 2023

Psychology Medicine Art

All healthcare providers are expected and required to deliver competent clinical care to an increasingly diverse population. For teaching-learning, more visual representations of DST and comparative images between what to expect in dark, m…

Dosimetric characterization of a rotating anode x‐ray tube for FLASH radiotherapy research Open

Devin Miles, Daniel Sforza, John Wong, Mohammad Rezaee · 2023

Materials science Physics Medicine

Purpose Most current research toward ultra‐high dose rate (FLASH) radiation is conducted with advanced proton and electron accelerators, which are of limited accessibility to basic laboratory research. An economical alternative to charged …

Individual Participant Data Network Meta-Analysis of Neoadjuvant Chemotherapy or Chemoradiotherapy in Esophageal or Gastroesophageal Junction Carcinoma Open

Matthieu Faron, M. Cheugoua-Zanetsie, Jayne F. Tierney, P. Thirion, Matthew Nankivell , et al. · 2023

Medicine

PURPOSE The optimal neoadjuvant treatment for resectable carcinoma of the thoracic esophagus (TE) or gastroesophageal junction (GEJ) remains a matter of debate. We performed an individual participant data (IPD) network meta-analysis (NMA) …

Risk-adjusted chemoradiation according to human papilloma viral status for anal cancer: a pilot study Open

William Chu, Amandeep Taggar, Yee Ung, Kelvin Chan, Craig C. Earle , et al. · 2023

Medicine

Background and purpose HPV-associated or positive (HPV+) anal cancer patients may have better outcome compared to those with HPV negative (HPV−) disease. We report a planned interim analysis of a prospective registry study that tailors che…

Supplemental Figure Legends from Elective Nodal Irradiation Attenuates the Combinatorial Efficacy of Stereotactic Radiation Therapy and Immunotherapy Open