Johny Neamţu
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Boron Bioavailability Revisited: From Plasma-Accessible Species to Microbiota-Accessible Complexes—Implications for Nutritional Essentiality Open
Boron (B) remains one of the least understood trace elements in human nutrition. Traditionally regarded as non-essential, its biological role has been reevaluated in light of emerging microbiome research. We provide a narrative synthesis o…
Microbiota-Accessible Borates as Novel and Emerging Prebiotics for Healthy Longevity: Current Research Trends and Perspectives Open
Precision nutrition-targeted gut microbiota (GM) may have therapeutic potential not only for age-related diseases but also for slowing the aging process and promoting longer healthspan. Recent studies have shown that restoring a healthy sy…
Phenolic Acid Investigation and In Vitro Antioxidant and Antiacetylcholinesterase Potentials of Galeopsis spp. (Lamiaceae) from Romanian Flora Open
Background/Objectives Galeopsis spp. (Lamiaceae) are widely distributed across extensive areas in Romania, being used mainly for their sedative, neuroprotective, antioxidant, anti-inflammatory, expectorant, astringent, and diuretic propert…
Phenolic Acids Investigation and <i>In Vitro</i> Antioxidant and Antiacetylcholinesterase Potential of <i>Galeopsis</i> spp. (<i>Lamiaceae</i>) from Romania Flora Open
Background/Objectives: Galeopsis spp. (Lamiaceae) are widely distributed across extensive areas in Romania, being used mainly for their sedative, neuroprotective, antioxidant, anti-inflammatory, expectorant, astringent and diuretic propert…
PRELIMINARY HPTLC INVESTIGATION OF TWO GALEOPSIS SPP. (LAMIACEAE) FROM SOUTHWEST ROMANIA FLORA Open
The paper highlights the phenolic acids content of roots, aerial parts and leaves of two Galeopsis spp. (Lamiaceae) from the southwest Romania (Oltenia Region) flora, using high-performance thin-layer chromatography (HPTLC) coupled with ph…
Simultaneous Determination of Epirubicin, Olaparib and Ribociclib in Human Serum by SPE-LC-MS Open
Epirubicin, olaparib and ribociclib are three anti-tumoral molecules currently used in cancer therapy. Since serum levels of these drugs reveal a large inter-individual variability, validation of a fast, simple and reliable analytical meth…
Zinc–Boron–PLGA biocomposite material: preparation, structural characterization, and in vitro assessment Open
Nowadays, the state-of-the-art discoveries in the field of delivery systems for therapeutic purposes have redefined the importance of biocompatible and biodegradable poly(lactic-co-glycolic acid (PLGA) nanocomposites. The study aimed to ob…
Zn–B–PLGA Biocomposite-Based Materials as Drug Delivery Systems: Research Progress Open
Our concern was to obtain a biocomposite material with improved properties of the constituent materials (poly(lactic- co-glycolic acid) (PLGA) and zinc–boron (Zn–B) complex) in accordance with the novelties in the field of delivery systems…
View article: Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives
Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives Open
Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide (NAD+) is involved in an extensive spectrum of human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes. Further…
View article: Nicotinamide Riboside, a Promising Vitamin B<sub>3</sub> Derivative for Healthy Aging and Longevity: Current Research and Perspectives
Nicotinamide Riboside, a Promising Vitamin B<sub>3</sub> Derivative for Healthy Aging and Longevity: Current Research and Perspectives Open
NAD+ is known classically as a metabolite that participates in catabolic and anabolic pathways throughout the metabolism that is taught to students in introductory biochemistry courses. However, non-classical studies starting over a decade…
Chemical and Antioxidant Profile of Hydroalcoholic Extracts of Stachys Officinalis L., Stachys Palustris L., Stachys Sylvatica L. from Romania Open
Stachys officinalis L., Stachys palustris L., Stachys sylvatica L. (Lamiaceae) are widely used as herbal remedies. In this study, comparative assessment of the phenolic acids, flavonoids, anthocyanin, and tannins content, together with ant…
BISPHOSPHONATES-PDA: CORRELATION BETWEEN STRUCTURE AND PHYSICOCHEMICAL PROPERTIES Open
Bisphosphonates are used to treat a number of bone related diseases such as osteosarcoma, malignant hypercalcemia, osteomyelitis. Developing novel drug delivery systems may overcome the adverse reactions caused by traditional administratio…
Diester Chlorogenoborate Complex: A New Naturally Occurring Boron-Containing Compound Open
The natural compounds of boron have many applications, primarily as a dietary supplement. The research is based on the discovery that the diester chlorogenoborate complex can be detected and quantified from green coffee beans. The study re…
Boron-containing compounds in Dentistry: a narrative review Open
Research on the use of boron (B) in the field of oral health has gained momentum in recent years, with various studies on the possibilities of using various B-containing compounds (BCCs). A multitude of applications have been discovered, f…
Diester Chlorogenoborate Complex: A New Naturally Occurring Boron-Containing Compound Open
The natural compounds of boron have many applications, including as dietary supplement. Communication is based on the discovery that diester chlorogenoborate complex can be detected and quantified from green coffee bean. The study reports …
New Insights into Boron Essentiality in Humans and Animals Open
Boron (B) is considered a prebiotic chemical element with a role in both the origin and evolution of life, as well as an essential micronutrient for some bacteria, plants, fungi, and algae. B has beneficial effects on the biological functi…
Simultaneous Determination of Two Tyrosine Kinase Inhibitors in Tablets by HPLC-MS analysis. Open
The class of tyrosine kinase inhibitors (TKIs) is represented by a group of compounds which are currently used in the treatment of different types of cancer. These oral medicines present a narrow therapeutic index and a large inter-and int…
Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial. Open
The current treatment of osteomyelitis includes systemic antibiotic therapy and a debridement procedure of the formed biofilm and necrotic tissue. Moreover, cements and three-dimensional scaffolds are used both for the delivery of therapeu…
PROCESS OPTIMIZATION USING QUALITY BY DESIGN (QBD) APPROACH OF A GENTAMICIN LOADED PLGA BIOCOMPOSITE Open
Osteomyelitis continues to be a major concern when orthopedic surgery is performed. Orthopedic infections have an incidence of 5% to 10% but their management proves to be quite difficult due to both biofilm formation and limited access of …
CCDC 2041235: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2041234: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2041231: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2041232: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Co (II), Cu (II), Mn (II), Ni (II), Pd (II), and Pt (II) complexes of bidentate Schiff base ligand: Synthesis, crystal structure, and acute toxicity evaluation Open
5‐methoxy‐2‐(((2chloro‐5‐(trifluoromethyl)phenyl)imino)methyl)phenol) (HL) and its cobalt (II), copper (II), manganese (II), nickel (II), palladium (II), and platinum (II) complexes, [Co(L) 2 ]·4H 2 O ( 1 ), [Cu(L) 2 ] ( 2 ), [Mn(L) 2 (H 2…
View article: IN VITRO CHARACTERIZATION OF HYDROXYAPATITE-BASED BIOMATERIALS, USING MESENCHYMAL STEM CELL CULTURES FROM HUMAN BONE MARROW
IN VITRO CHARACTERIZATION OF HYDROXYAPATITE-BASED BIOMATERIALS, USING MESENCHYMAL STEM CELL CULTURES FROM HUMAN BONE MARROW Open
There is considerable interest in the discovery of biomimetic materials that improve cell adhesion and reduce the time of bone integration of implants. In vitro bone cells biocompatibility was performed for the two types of biocomposites h…
CCDC 1957157: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 1957156: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 1957150: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
In Vivo Assessment of Bone Enhancement in the Case of 3D-Printed Implants Functionalized with Lithium-Doped Biological-Derived Hydroxyapatite Coatings: A Preliminary Study on Rabbits Open
We report on biological-derived hydroxyapatite (HA, of animal bone origin) doped with lithium carbonate (Li-C) and phosphate (Li-P) coatings synthesized by pulsed laser deposition (PLD) onto Ti6Al4V implants, fabricated by the additive man…