Jolyane Meloche
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View article: Longitudinal follow-up of the asthma status in a French–Canadian cohort
Longitudinal follow-up of the asthma status in a French–Canadian cohort Open
View article: Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naïve CD4+ T cells
Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naïve CD4+ T cells Open
View article: PIM1 (Moloney Murine Leukemia Provirus Integration Site) Inhibition Decreases the Nonhomologous End-Joining DNA Damage Repair Signaling Pathway in Pulmonary Hypertension
PIM1 (Moloney Murine Leukemia Provirus Integration Site) Inhibition Decreases the Nonhomologous End-Joining DNA Damage Repair Signaling Pathway in Pulmonary Hypertension Open
Objective: Pulmonary arterial hypertension (PAH) is a fatal disease characterized by the narrowing of pulmonary arteries (PAs). It is now established that this phenotype is associated with enhanced PA smooth muscle cells (PASMCs) prolifera…
View article: Exome sequencing study of partial agenesis of the corpus callosum in men with developmental delay, epilepsy, and microcephaly
Exome sequencing study of partial agenesis of the corpus callosum in men with developmental delay, epilepsy, and microcephaly Open
Background This study reports the genetic features of four Caucasian males from the Saguenay‒Lac‐St‐Jean region affected by partial agenesis of the corpus callosum (ACC) with hypotonia, epilepsy, developmental delay, microcephaly, hypoplas…
View article: <i>GSDMA</i>drives the most replicated association with asthma in naïve CD4<sup>+</sup>T cells
<i>GSDMA</i>drives the most replicated association with asthma in naïve CD4<sup>+</sup>T cells Open
Background The 17q12-21 locus is the most replicated association with asthma. However, no study had described the genetic mechanisms underlying this association considering all genes of the locus in immune cell samples isolated from asthma…
View article: Contribution of the Saguenay–Lac-Saint-Jean asthma familial cohort in the omic landscape of asthma
Contribution of the Saguenay–Lac-Saint-Jean asthma familial cohort in the omic landscape of asthma Open
Asthma is a chronic respiratory disease afflicting patients of all ages and, despite recent therapeutic advances, still causes important morbidity and mortality. The implication of genetic alterations and the role for environmental factors…
View article: Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension
Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension Open
Our data show for the first time that accumulation of mtHSP90 is a feature of PAH-PASMCs and a key regulator of mitochondrial homeostasis contributing to vascular remodeling in PAH.
View article: ECHOCARDIOGRAPHIC INTERPRETATION SKILLS OF GRADUATING CARDIOLOGY TRAINEES: ARE THEY COMPETENT?
ECHOCARDIOGRAPHIC INTERPRETATION SKILLS OF GRADUATING CARDIOLOGY TRAINEES: ARE THEY COMPETENT? Open
View article: Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension
Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension Open
Objective— Pulmonary arterial hypertension (PAH) is a vascular disease not restricted to the lungs. Many signaling pathways described in PAH are also of importance in other vascular remodeling diseases, such as coronary artery disease (CAD…
View article: DNA Damage and Pulmonary Hypertension
DNA Damage and Pulmonary Hypertension Open
Pulmonary hypertension (PH) is defined by a mean pulmonary arterial pressure over 25 mmHg at rest and is diagnosed by right heart catheterization. Among the different groups of PH, pulmonary arterial hypertension (PAH) is characterized by …
View article: DNA DAMAGE AT THE DAWN OF MICRO-RNA PATHWAY IMPAIRMENT IN PULMONARY ARTERIAL HYPERTENSION
DNA DAMAGE AT THE DAWN OF MICRO-RNA PATHWAY IMPAIRMENT IN PULMONARY ARTERIAL HYPERTENSION Open
Over the last years, small non-coding microRNAs (miRNAs) have emerged as central actors of PAH etiology. Strong miRNA expression disorders occur in lungs as well as in right ventricle (RV) of PAH patients, which respectively lead to vascul…