Jon Jacobs
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View article: Correction: Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region
Correction: Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region Open
[This corrects the article DOI: 10.1371/journal.pone.0250586.].
View article: Astrocyte FABP7 Modulates Seizure Activity-Dependent Protein Expression in Mouse Brain
Astrocyte FABP7 Modulates Seizure Activity-Dependent Protein Expression in Mouse Brain Open
Background/Objectives: Patients with epilepsy commonly experience patterns of seizures that change with sleep/wake behavior or diurnal rhythms. The cellular and molecular mechanisms that underlie these patterns in seizure activity are not …
View article: Plasma proteomic biomarkers of physical frailty in heart failure: a propensity score matched discovery-based pilot study
Plasma proteomic biomarkers of physical frailty in heart failure: a propensity score matched discovery-based pilot study Open
Proteomic biomarkers related to the immune system, stress response, and detoxification were differentially expressed between physically frail and non-physically frail adults with HF.
View article: Lipid droplet‐associated proteins in alcohol‐associated fatty liver disease: A proteomic approach
Lipid droplet‐associated proteins in alcohol‐associated fatty liver disease: A proteomic approach Open
Background The earliest manifestation of alcohol‐associated liver disease (ALD) is steatosis characterized by deposition of fat in specialized organelles called lipid droplets (LDs). While alcohol administration causes a rise in LD numbers…
View article: Coupling Microdroplet-Based Sample Preparation, Multiplexed Isobaric Labeling, and Nanoflow Peptide Fractionation for Deep Proteome Profiling of the Tissue Microenvironment
Coupling Microdroplet-Based Sample Preparation, Multiplexed Isobaric Labeling, and Nanoflow Peptide Fractionation for Deep Proteome Profiling of the Tissue Microenvironment Open
There is increasing interest in developing in-depth proteomic approaches for mapping tissue heterogeneity in a cell-type-specific manner to better understand and predict the function of complex biological systems such as human organs. Exis…
View article: Molecular-Level Dysregulation of Insulin Pathways and Inflammatory Processes in Peripheral Blood Mononuclear Cells by Circadian Misalignment
Molecular-Level Dysregulation of Insulin Pathways and Inflammatory Processes in Peripheral Blood Mononuclear Cells by Circadian Misalignment Open
Circadian misalignment due to night work has been associated with an elevated risk for chronic diseases. We investigated the effects of circadian misalignment using shotgun protein profiling of peripheral blood mononuclear cells taken from…
View article: Proteomics identifies complement protein signatures in patients with alcohol-associated hepatitis
Proteomics identifies complement protein signatures in patients with alcohol-associated hepatitis Open
Diagnostic challenges continue to impede development of effective therapies for successful management of alcohol-associated hepatitis (AH), creating an unmet need to identify noninvasive biomarkers for AH. In murine models, complement cont…
View article: Steroid responsiveness in alcohol-associated hepatitis is linked to glucocorticoid metabolism, mitochondrial repair, and heat shock proteins
Steroid responsiveness in alcohol-associated hepatitis is linked to glucocorticoid metabolism, mitochondrial repair, and heat shock proteins Open
Background: Alcohol-associated hepatitis (AH) is one of the clinical presentations of alcohol-associated liver disease. AH has poor prognosis, and corticosteroids remain the mainstay of drug therapy. However, ~40% of patients do not respon…
View article: Longitudinal analysis of host protein serum signatures of treatment and recovery in pulmonary tuberculosis
Longitudinal analysis of host protein serum signatures of treatment and recovery in pulmonary tuberculosis Open
Background A better understanding of treatment progression and recovery in pulmonary tuberculosis (TB) infectious disease is crucial. This study analyzed longitudinal serum samples from pulmonary TB patients undergoing interventional treat…
View article: Identification of integrated proteomics and transcriptomics signature of alcohol-associated liver disease using machine learning
Identification of integrated proteomics and transcriptomics signature of alcohol-associated liver disease using machine learning Open
Distinguishing between alcohol-associated hepatitis (AH) and alcohol-associated cirrhosis (AC) remains a diagnostic challenge. In this study, we used machine learning with transcriptomics and proteomics data from liver tissue and periphera…