Jon B. Patteson
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View article: Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition
Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition Open
Outer membrane proteins (OMPs) produced by Gram-negative bacteria contain a cylindrical amphipathic β-sheet (“β-barrel”) that functions as a membrane spanning domain. The assembly (folding and membrane insertion) of OMPs is mediated by the…
View article: Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme
Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme Open
Heme oxygenase-like domain-containing oxidases (HDOs) are a rapidly expanding enzyme family that typically use dinuclear metal cofactors instead of heme. FlcD, an HDO from the opportunistic pathogen Pseudomonas aeruginosa, catalyzes…
View article: Abstract 2470 A copper-containing antibiotic produced by Pseudomonas
Abstract 2470 A copper-containing antibiotic produced by Pseudomonas Open
Pseudomonas species colonize and infect a broad range of eukaryotic hosts. Infection by these bacteria can significantly impact the diversity and composition of the microbiota of the hosts. Pseudomonas produce many natural products, includ…
View article: Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis
Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis Open
Protein sequences are provided which were used for generation of all bioinformatics figures. Sequence similarity network generated using C domains is also included.
View article: Biosynthesis of fluopsin C, a copper-containing antibiotic from <i>Pseudomonas aeruginosa</i>
Biosynthesis of fluopsin C, a copper-containing antibiotic from <i>Pseudomonas aeruginosa</i> Open
A copper-containing antibiotic Bacteria require transition metal ions for biological processes and must also protect themselves against excess metal, which is toxic. Patteson et al . explored how the environmental bacterium Pseudomonas aer…
View article: Heme oxygenase pfam14518 sequence similarity network
Heme oxygenase pfam14518 sequence similarity network Open
Sequence similarity network generated from pfam14518 using the EFI-GNT webtool. Each node is representative of sequences that are 80% identical.
View article: Heme oxygenase pfam14518 sequence similarity network
Heme oxygenase pfam14518 sequence similarity network Open
Sequence similarity network generated from pfam14518 using the EFI-GNT webtool. Each node is representative of sequences that are 80% identical.
View article: Discovery and Biosynthesis of Azabicyclene, a Conserved Nonribosomal Peptide in <i>Pseudomonas aeruginosa</i>
Discovery and Biosynthesis of Azabicyclene, a Conserved Nonribosomal Peptide in <i>Pseudomonas aeruginosa</i> Open
Azabicyclene, an azetidine-containing natural product, was identified using quorum-sensing molecules to upregulate expression of a gene cluster highly conserved in the human pathogen Pseudomonas aeruginosa. Mutational studies of the gene c…
View article: Controlling and quantifying protein concentration in <i>Escherichia coli</i>
Controlling and quantifying protein concentration in <i>Escherichia coli</i> Open
The cellular environment is dynamic and complex, involving thousands of different macromolecules with total concentrations of hundreds of grams per liter. However, most biochemistry is conducted in dilute buffer where the concentration of …
View article: Phevamine A, a small molecule that suppresses plant immune responses
Phevamine A, a small molecule that suppresses plant immune responses Open
Significance Bacterial pathogens cause plant diseases that threaten the global food supply. To control diseases, it is important to understand how pathogenic bacteria evade plant defense and promote infection. We identify from the phytopat…
View article: Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin
Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin Open
Diketopiperazines (DKPs) make up a large group of natural products with diverse structures and biological activities. Bicyclomycin is a broad-spectrum DKP antibiotic with unique structure and function: it contains a highly oxidized bicycli…
View article: Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities
Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities Open
View article: Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(<scp>iii</scp>) ylides
Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(<span>iii</span>) ylides Open
Theoretical studies provide insight into radiofluorination of non-activated electron-rich and sterically hindered 18 F-arenes using a new class of adamantyl-based spirocyclic iodonium( iii ) ylide precursors.