Jonathan Bath
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View article: Mechanism for a molecular assembler of sequence-controlled polymers using parallel DNA and a DNA polymerase
Mechanism for a molecular assembler of sequence-controlled polymers using parallel DNA and a DNA polymerase Open
Parallel DNA is used to juxtapose two 3′ ends at the end of a DNA helix.
View article: Controlling DNA–RNA strand displacement kinetics with base distribution
Controlling DNA–RNA strand displacement kinetics with base distribution Open
DNA–RNA hybrid strand displacement underpins the function of many natural and engineered systems. Understanding and controlling factors affecting DNA–RNA strand displacement reactions is necessary to enable control of processes such as CRI…
View article: Programmable self-assembly for scalable molecular electronic architectures
Programmable self-assembly for scalable molecular electronic architectures Open
Molecular electronics and other technologies whose components comprise individual molecules have been pursued for half a century because the molecular scale represents the limit of miniaturisation of objects whose structure is tuneable for…
View article: Tissue-specific modulation of CRISPR activity by miRNA-sensing guide RNAs
Tissue-specific modulation of CRISPR activity by miRNA-sensing guide RNAs Open
Nucleic acid nanostructures offer unique opportunities for biomedical applications due to their sequence-programmable structures and functions, which enable the design of complex responses to molecular cues. Control of the biological activ…
View article: Ice nucleation by DNA origami
Ice nucleation by DNA origami Open
Addition of DNA tiles lowers the temperature of ice nucleation.
View article: Tissue-specific modulation of CRISPR activity by miRNA-sensing guide RNAs
Tissue-specific modulation of CRISPR activity by miRNA-sensing guide RNAs Open
Nucleic acid nanostructures offer unique opportunities for biomedical applications due to their sequence-programmable structures and functions, which enable the design of complex responses to molecular cues. Control of the biological activ…
View article: Controlling DNA-RNA strand displacement kinetics with base distribution
Controlling DNA-RNA strand displacement kinetics with base distribution Open
DNA-RNA hybrid strand displacement underpins the function of many natural and engineered systems. Understanding and controlling factors affecting DNA-RNA strand displacement reactions is necessary to enable control of processes such as CRI…
View article: A New Architecture for DNA‐Templated Synthesis in Which Abasic Sites Protect Reactants from Degradation
A New Architecture for DNA‐Templated Synthesis in Which Abasic Sites Protect Reactants from Degradation Open
The synthesis of artificial sequence‐defined polymers that match and extend the functionality of proteins is an important goal in materials science. One way of achieving this is to program a sequence of chemical reactions between precursor…
View article: A New Architecture for DNA‐Templated Synthesis in Which Abasic Sites Protect Reactants from Degradation
A New Architecture for DNA‐Templated Synthesis in Which Abasic Sites Protect Reactants from Degradation Open
The synthesis of artificial sequence‐defined polymers that match and extend the functionality of proteins is an important goal in materials science. One way of achieving this is to program a sequence of chemical reactions between precursor…
View article: DNA-Based Optical Sensors for Forces in Cytoskeletal Networks
DNA-Based Optical Sensors for Forces in Cytoskeletal Networks Open
Mechanical forces are relevant for many biological processes, from wound healing and tumor formation to cell migration and differentiation. Cytoskeletal actin is largely responsible for responding to forces and transmitting them in cells, …
View article: A modular RNA delivery system comprising spherical nucleic acids built on endosome-escaping polymeric nanoparticles
A modular RNA delivery system comprising spherical nucleic acids built on endosome-escaping polymeric nanoparticles Open
Polymeric spherical nucleic acids comprise pH-sensitive, polymer-conjugated oligonucleotides that self-assemble into nanoparticles with the ability to escape endosomes, overcoming a major obstacle in nucleic acid delivery.
View article: A DNA molecular printer capable of programmable positioning and patterning in two dimensions
A DNA molecular printer capable of programmable positioning and patterning in two dimensions Open
Nanoscale manipulation and patterning usually require costly and sensitive top-down techniques such as those used in scanning probe microscopies or in semiconductor lithography. DNA nanotechnology enables exploration of bottom-up fabricati…
View article: A DNA-based optical force sensor for live-cell applications
A DNA-based optical force sensor for live-cell applications Open
Mechanical forces are relevant for many biological processes, from wound healing or tumour formation to cell migration and differentiation. Cytoskeletal actin is largely responsible for responding to forces and transmitting them in cells, …
View article: Strategies for Constructing and Operating DNA Origami Linear Actuators
Strategies for Constructing and Operating DNA Origami Linear Actuators Open
Linear actuators are ubiquitous components at all scales of engineering. DNA nanotechnology offers a unique opportunity for bottom‐up assembly at the molecular scale, providing nanoscale precision with multiple methods for constructing and…
View article: Characterising DNA T-motifs by Simulation and Experiment
Characterising DNA T-motifs by Simulation and Experiment Open
The success of DNA nanotechnology has been driven by the discovery of novel structural motifs with a wide range of shapes and uses. We present a comprehensive study of the T-motif, a 3-armed, planar, right-angled junction that has been use…
View article: Supplementary data for Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
Supplementary data for Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement Open
Data and processing scripts accompanying the publication.
View article: Supplementary data for Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
Supplementary data for Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement Open
Data and processing scripts accompanying the publication.
View article: Supplementary data for Rational design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
Supplementary data for Rational design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement Open
Data and processing scripts accompanying the publication.
View article: Controlling the Bioreceptor Spatial Distribution at the Nanoscale for Single Molecule Counting in Microwell Arrays
Controlling the Bioreceptor Spatial Distribution at the Nanoscale for Single Molecule Counting in Microwell Arrays Open
The ability to detect low concentrations of protein biomarkers is crucial for the early-stage detection of many diseases and therefore indispensable for improving diagnostic devices for healthcare. Here, we demonstrate that by integrating …
View article: Peptide Assembly Directed and Quantified Using Megadalton DNA Nanostructures
Peptide Assembly Directed and Quantified Using Megadalton DNA Nanostructures Open
In nature, co-assembly of polypeptides, nucleic acids, and polysaccharides is used to create functional supramolecular structures. Here, we show that DNA nanostructures can be used to template interactions between peptides and to enable th…
View article: Rational design of hidden thermodynamic driving through DNA mismatch repair
Rational design of hidden thermodynamic driving through DNA mismatch repair Open
Recent years have seen great advances in the development of synthetic self-assembling molecular systems. Designing out-of-equilibrium architectures, however, requires a more subtle control over the thermodynamics and kinetics of reactions.…
View article: Modelling DNA origami self-assembly at the domain level
Modelling DNA origami self-assembly at the domain level Open
We present a modelling framework, and basic model parameterization, for the study of DNA origami folding at the level of DNA domains. Our approach is explicitly kinetic and does not assume a specific folding pathway. The binding of each st…