Jon Botthoff
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View article: Lung microbiomes’ variable responses to dust exposure in mouse models of asthma
Lung microbiomes’ variable responses to dust exposure in mouse models of asthma Open
Inhalation of dust is significant and relevant to health effects. As pollution and climate change worsen in dryland regions, wind currents entrain loose sediment and dust. This potentially disperses toxic geochemical and microbial burdens …
View article: Evidence for Aerosolized Environmental Bacterial Endotoxin as an Environmental Health Hazard
Evidence for Aerosolized Environmental Bacterial Endotoxin as an Environmental Health Hazard Open
The high incidence of asthma near California’s Salton Sea is attributed to dust emitted from the exposed lakebed. A survey of clinical symptoms conducted in the region revealed distinct spatial distribution with strong geospatial correlati…
View article: Microbial community structure in recovering forests of Mount St. Helens
Microbial community structure in recovering forests of Mount St. Helens Open
Introduction The 1980 eruption of Mount St. Helens had devastating effects above and belowground in forested montane ecosystems, including the burial and destruction of soil microbes. Soil microbial propagules and legacies in recovering ec…
View article: Leafcutter ants enhance microbial drought resilience in tropical forest soil
Leafcutter ants enhance microbial drought resilience in tropical forest soil Open
We conducted a research campaign in a neotropical rainforest in Costa Rica throughout the drought phase of an El‐Nino Southern Oscillation event to determine microbial community dynamics and soil C fluxes. Our study included nests of the l…
View article: Bacterial denitrification drives elevated N <sub>2</sub> O emissions in arid southern California drylands
Bacterial denitrification drives elevated N <sub>2</sub> O emissions in arid southern California drylands Open
Soils are the largest source of atmospheric nitrous oxide (N 2 O), a powerful greenhouse gas. Dry soils rarely harbor anoxic conditions to favor denitrification, the predominant N 2 O-producing process, yet, among the largest N 2 O emissio…
View article: Nitrous oxide emission and isotopic composition data from four dryland sites in Southern California
Nitrous oxide emission and isotopic composition data from four dryland sites in Southern California Open
This data publication includes in-situ nitrous oxide and nitric oxide emissions measured in four dryland sites in Southern California between June 2019 and August 2020. Emissions were measured from eight locations within each site every 15…
View article: Soil NH3 emissions across an aridity, soil pH, and N deposition gradient in southern California
Soil NH3 emissions across an aridity, soil pH, and N deposition gradient in southern California Open
Soil ammonia (NH3) emissions are seldom included in ecosystem nutrient budgets; however, they may represent substantial pathways for ecosystem nitrogen (N) loss, especially in arid regions where hydrologic N losses are comparatively small.…
View article: Aerosolized aqueous dust extracts collected near a drying lake trigger acute neutrophilic pulmonary inflammation reminiscent of microbial innate immune ligands
Aerosolized aqueous dust extracts collected near a drying lake trigger acute neutrophilic pulmonary inflammation reminiscent of microbial innate immune ligands Open
Lung inflammatory responses to Salton Sea dusts are similar to acute innate immune responses, raising the possibility that microbial components are entrained in the dust, promoting inflammation. This effect highlights the health risks at d…
View article: Aerosolized Desert Dusts Collected Near a Drying Lake and Pulmonary Inflammation in Mice: Implications for Environmental Exposures and Asthma
Aerosolized Desert Dusts Collected Near a Drying Lake and Pulmonary Inflammation in Mice: Implications for Environmental Exposures and Asthma Open
Background A high incidence of asthma is prevalent among residents near the Salton Sea, a large inland terminal lake in southern California. This arid region has high levels of ambient particulate matter (PM); yet while high PM levels are …
View article: Baja California Sur mangrove deep peat microbial communities cycle nitrogen but do not affect old carbon pool
Baja California Sur mangrove deep peat microbial communities cycle nitrogen but do not affect old carbon pool Open
Mangroves provide important ecosystem services, including storing carbon belowground for millennia. Mangrove carbon storage relies in part on high primary productivity, but essential to the long-lived nature of this storage is the slow rat…
View article: Landscape Topography and Regional Drought Alters Dust Microbiomes in the Sierra Nevada of California
Landscape Topography and Regional Drought Alters Dust Microbiomes in the Sierra Nevada of California Open
Dust provides an ecologically significant input of nutrients, especially in slowly eroding ecosystems where chemical weathering intensity limits nutrient inputs from underlying bedrock. In addition to nutrient inputs, incoming dust is a ve…
View article: Rapid nitrate reduction produces pulsed NO and N2O emissions following wetting of dryland soils
Rapid nitrate reduction produces pulsed NO and N2O emissions following wetting of dryland soils Open
Soil drying and wetting cycles can produce pulses of nitric oxide (NO) and nitrous oxide (N 2 O) emissions with substantial effects on both regional air quality and Earth’s climate. While pulsed production of N emissions is ubiquitous acro…
View article: Enriched root bacterial microbiome in invaded vs native ranges of the model grass allotetraploid Brachypodium hybridum
Enriched root bacterial microbiome in invaded vs native ranges of the model grass allotetraploid Brachypodium hybridum Open
Invasive species can shift the composition of key soil microbial groups, thus creating novel soil microbial communities. To better understand the biological drivers of invasion, we studied plant-microbial interactions in species of the Bra…
View article: Lung Inflammatory Response to Environmental Dust Exposure in Mice Suggests a Link to Regional Respiratory Disease Risk
Lung Inflammatory Response to Environmental Dust Exposure in Mice Suggests a Link to Regional Respiratory Disease Risk Open
These investigations demonstrate potent lung inflammatory responses and tissue remodeling in response to SSDE, in part due to environmental proteases found within the dusts. These studies provide the first evidence supporting a link betwee…
View article: Continental-scale patterns of extracellular enzyme activity in the subsoil: an overlooked reservoir of microbial activity
Continental-scale patterns of extracellular enzyme activity in the subsoil: an overlooked reservoir of microbial activity Open
Chemical stabilization of microbial-derived products such as extracellular enzymes (EE) onto mineral surfaces has gained attention as a possibly important mechanism leading to the persistence of soil organic carbon (SOC). While the control…
View article: Pulses of Biogenic Nitrogen Cycling Lead to Atmospheric-Based Nutrient Spiraling in Southern California
Pulses of Biogenic Nitrogen Cycling Lead to Atmospheric-Based Nutrient Spiraling in Southern California Open
<p>Nitrogen deposition into arid ecosystems is increasingly shaping biogeochemical dynamics worldwide. We propose a framework to investigate the role of pulsed soil N emission as a mechanism that relays the influences of atmospheric …
View article: Ecological and Genomic Attributes of Novel Bacterial Taxa That Thrive in Subsurface Soil Horizons
Ecological and Genomic Attributes of Novel Bacterial Taxa That Thrive in Subsurface Soil Horizons Open
Soil profiles are rarely homogeneous. Resource availability and microbial abundances typically decrease with soil depth, but microbes found in deeper horizons are still important components of terrestrial ecosystems. By studying 20 soil pr…
View article: ENSO‐Influenced Drought Drives Methane Flux Dynamics in a Tropical Wet Forest Soil
ENSO‐Influenced Drought Drives Methane Flux Dynamics in a Tropical Wet Forest Soil Open
Global atmospheric methane growth rates have wildly fluctuated over the past three decades, which may be driven by the proportion of tropical land surface saturated by water. The El Niño/Southern Oscillation Event (ENSO) cycle drives large…
View article: Ecological and genomic attributes of novel bacterial taxa that thrive in subsurface soil horizons
Ecological and genomic attributes of novel bacterial taxa that thrive in subsurface soil horizons Open
While most bacterial and archaeal taxa living in surface soils remain undescribed, this problem is exacerbated in deeper soils owing to the unique oligotrophic conditions found in the subsurface. Additionally, previous studies of soil micr…
View article: Establishment and characterization of a multi-purpose large animal exposure chamber for investigating health effects
Establishment and characterization of a multi-purpose large animal exposure chamber for investigating health effects Open
Air pollution poses a significant threat to the environment and human health. Most in vivo health studies conducted regarding air pollutants, including particulate matter (PM) and gas phase pollutants, have been either through traditional …
View article: Establishment and Characterization of a Multi-Purpose Large Animal Exposure Chamber for Investigating Health Effects
Establishment and Characterization of a Multi-Purpose Large Animal Exposure Chamber for Investigating Health Effects Open
Air pollution poses a significant threat to the environment and human health. Most in-vivo health studies conducted regarding air pollutants, including particulate matter (PM) and gas phase pollutants, have been either through traditional …