Jon Brassey
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View article: Viral cultures for assessing airborne infectiousness of SARS-CoV-2: a systematic review and meta-analysis
Viral cultures for assessing airborne infectiousness of SARS-CoV-2: a systematic review and meta-analysis Open
Introduction There is uncertainty about the quantification, viability and infectivity of SARS-CoV-2 in air samples. Our objective was to systematically review the evidence for air sample virus infectiousness with high-level confirmatory st…
View article: Oro-faecal transmission of SARS-CoV-2: A systematic review of studies employing viral culture from gastrointestinal and other potential sources
Oro-faecal transmission of SARS-CoV-2: A systematic review of studies employing viral culture from gastrointestinal and other potential sources Open
Background The extent to which the oro-faecal route contributes to the transmission of SARS-CoV-2 is not established. Methods We systematically reviewed the evidence on the presence of infectious SARS-CoV-2 in faeces and other gastrointest…
View article: What are the environmental factors that affect respiratory viral pathogen transmission and outcomes? A scoping review of the published literature
What are the environmental factors that affect respiratory viral pathogen transmission and outcomes? A scoping review of the published literature Open
Introduction Respiratory viral pathogens are a major cause of morbidity and mortality, and there is a need to understand how to prevent their transmission. Methods We performed a scoping review to assess the amount and scope of published r…
View article: Oro-faecal transmission of SARS-CoV-2: A systematic review of studies employing viral culture from gastrointestinal and other potential oro-faecal sources and evidence for transmission to humans
Oro-faecal transmission of SARS-CoV-2: A systematic review of studies employing viral culture from gastrointestinal and other potential oro-faecal sources and evidence for transmission to humans Open
The extent to which the oro-faecal route contributes to the transmission of SARS-CoV-2 is not established. We systematically reviewed the evidence on the presence of infectious SARS-CoV-2 in faeces and other gastrointestinal sources by exa…
View article: SARS-CoV-2 and the role of close contact in transmission: a systematic review
SARS-CoV-2 and the role of close contact in transmission: a systematic review Open
Background: SARS-CoV-2 transmission has been reported to be associated with close contact with infected individuals. However, the mechanistic pathway for transmission in close contact settings is unclear. Our objective was to identify, app…
View article: SARS-CoV-2 and the role of airborne transmission: a systematic review
SARS-CoV-2 and the role of airborne transmission: a systematic review Open
Background: Airborne transmission is the spread of an infectious agent caused by the dissemination of droplet nuclei (aerosols) that remain infectious when suspended in the air. We carried out a systematic review to identify, appraise and …
View article: Transmission of SARS-CoV-2 Associated with Cruise Ship Travel: A Systematic Review
Transmission of SARS-CoV-2 Associated with Cruise Ship Travel: A Systematic Review Open
Background: Maritime and river travel may be associated with respiratory viral spread via infected passengers and/or crew and potentially through other transmission routes. The transmission models of SARS-CoV-2 associated with cruise ship …
View article: Viral cultures for assessing fomite transmission of SARS-CoV-2: a systematic review and meta-analysis
Viral cultures for assessing fomite transmission of SARS-CoV-2: a systematic review and meta-analysis Open
The evidence from published studies suggests that replication-competent SARS-CoV-2 is present on fomites. Replication-competent SARS-CoV-2 is significantly more likely when the PCR CT for clinical specimens and fomite samples is <30. Furth…
View article: A Hierarchical Framework for Assessing Transmission Causality of Respiratory Viruses
A Hierarchical Framework for Assessing Transmission Causality of Respiratory Viruses Open
Systematic reviews of 591 primary studies of the modes of transmission for SARS-CoV-2 show significant methodological shortcomings and heterogeneity in the design, conduct, testing, and reporting of SARS-CoV-2 transmission. While this is p…
View article: SARS-CoV-2 and the role of close contact in transmission: a systematic review
SARS-CoV-2 and the role of close contact in transmission: a systematic review Open
Background: SARS-CoV-2 transmission has been reported to be associated with close contact with infected individuals. However, the mechanistic pathway for transmission in close contact settings is unclear. Our objective was to identify, app…
View article: A Hierarchical Framework for Assessing Transmission Causality of Respiratory Viruses
A Hierarchical Framework for Assessing Transmission Causality of Respiratory Viruses Open
Systematic reviews of 591 primary studies of the modes of transmission for SARS-CoV-2 show significant methodological shortcomings and heterogeneity in the design, conduct, testing and reporting of SARS-CoV-2 transmission. While this is pa…
View article: Understanding Definitions and Reporting of Deaths Attributed to COVID-19 in the UK – Evidence from FOI Requests
Understanding Definitions and Reporting of Deaths Attributed to COVID-19 in the UK – Evidence from FOI Requests Open
Death is a widely used outcome to assess the severity of pandemics. Accuracy in assigning the cause of death is of vital importance to define the impact of the agent, monitor its evolution, and compare its threat with those of other agents…
View article: PCR Testing in the UK During the SARS-CoV-2 Pandemic – Evidence from FOI Requests
PCR Testing in the UK During the SARS-CoV-2 Pandemic – Evidence from FOI Requests Open
Polymerase Chain Reaction (“PCR”) tests have been used to identify cases of COVID-19 during the course of the pandemic. Notably, PCR alone cannot differentiate between the presence of whole viruses (which can be transmitted and infect indi…
View article: Effects of COVID-19 in Care Homes - A Mixed Methods Review
Effects of COVID-19 in Care Homes - A Mixed Methods Review Open
Introduction The report provides an up-to-date review of the global effects of the COVID-19 pandemic in care homes. We used a mixed methods approach to assess care home mortality by country, how the deaths compared with previous periods, a…
View article: Search filter for combat injuries.
Search filter for combat injuries. Open
A search string, design for the Trip Database (www.tripdatabase.com) to identify evidence to support health care in war/combat settings.
View article: Viral cultures, Polymerase Chain Reaction Cycle Threshold Values and Viral Load Estimation for SARS-CoV-2 Infectious Potential Assessment in Hematopoietic Stem Cell and Solid Organ Transplant Patients: A Systematic Review
Viral cultures, Polymerase Chain Reaction Cycle Threshold Values and Viral Load Estimation for SARS-CoV-2 Infectious Potential Assessment in Hematopoietic Stem Cell and Solid Organ Transplant Patients: A Systematic Review Open
Background Organ transplant recipients are at increased vulnerability to SARS-CoV-2 due to immunosuppression and may pose a continued transmission risk especially within hospital settings. Detailed case reports including symptoms, viral lo…
View article: Viral Cultures for Assessing Airborne Transmission of SARs-CoV-2: a Systematic Review Protocol (version 1)
Viral Cultures for Assessing Airborne Transmission of SARs-CoV-2: a Systematic Review Protocol (version 1) Open
This is a protocol for a systematic review that aims to evaluate the role of viral cultures for assessing airborne transmission of SARS-CoV-2. The review will address the following research questions: Are airborne samples infectious? If so…
View article: Viral Cultures for Assessing Fomites Transmission of SARS-CoV-2: a Systematic
Viral Cultures for Assessing Fomites Transmission of SARS-CoV-2: a Systematic Open
This is a protocol for a systematic review to assess fomite transmission in SARS-CoV-2. Our research questions are as follows: Are fomite samples infectious? If so, what proportion are infectious, and what is the distance and duration of i…
View article: Interventions designed to improve vaccination uptake: Scoping review of systematic reviews and meta-analyses - (version 1)
Interventions designed to improve vaccination uptake: Scoping review of systematic reviews and meta-analyses - (version 1) Open
Background Resources to ensure high vaccination uptake differ widely across countries, but the best use of these precious resources is unclear. To better meet immunization programmes’ a pressing need to understand what works, particularly …
View article: Viral cultures, PCR Cycle threshold values and viral load estimation for COVID-19 infectious potential assessment in transplant patients: systematic review - Protocol Version 30 December 2021
Viral cultures, PCR Cycle threshold values and viral load estimation for COVID-19 infectious potential assessment in transplant patients: systematic review - Protocol Version 30 December 2021 Open
This is the protocol for a systematic review focussing on people receiving solid organ or hematopoietic stem cell transplants. Our research questions are as follows: What is the relationship between serial PCR Ct value or other measures of…
View article: SARS-CoV-2 and the role of orofecal transmission: a systematic review
SARS-CoV-2 and the role of orofecal transmission: a systematic review Open
Background: Modes of transmission of SARS-CoV-2 are of key public health importance. SARS-CoV-2 has been detected in the feces of some COVID-19 patients, suggesting the possibility that the virus could, in addition to droplet and fomite tr…
View article: Transmission of SARS-CoV-2 associated with cruise ship travel: protocol for a systematic review (Version 1)
Transmission of SARS-CoV-2 associated with cruise ship travel: protocol for a systematic review (Version 1) Open
Background Maritime and river travel, including cruise ships, have been implicated with spreading viruses through infected passengers and crew. Given the novelty of the SARS-CoV-2 infection, early cruise ship travel transmission models of …
View article: SARS-CoV-2 and the role of airborne transmission: a systematic review
SARS-CoV-2 and the role of airborne transmission: a systematic review Open
Background: Airborne transmission is the spread of an infectious agent caused by the dissemination of droplet nuclei (aerosols) that remain infectious when suspended in the air. We carried out a systematic review to identify, appraise and …
View article: Interventions designed to improve vaccination uptake: Scoping review of systematic reviews and meta-analyses - protocol (version 1)
Interventions designed to improve vaccination uptake: Scoping review of systematic reviews and meta-analyses - protocol (version 1) Open
Background Vaccine uptake varies substantially, and resources to promote the uptake of vaccines differ widely by country and income level. As a result, immunization rates are often suboptimal. There is a need to understand what works, part…
View article: Transmission of SARS-CoV-2 associated with aircraft travel: a systematic review
Transmission of SARS-CoV-2 associated with aircraft travel: a systematic review Open
Rationale for the review Air travel may be associated with viruses spread via infected passengers and potentially through in-flight transmission. Given the novelty of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, …
View article: Transmission of SARS-CoV-2 from pre and asymptomatic infected individuals. A systematic review
Transmission of SARS-CoV-2 from pre and asymptomatic infected individuals. A systematic review Open
Background The transmission role of SARS-Cov-2 infected persons who develop symptoms post testing (pre symptomatics) or not at all throughout the course of positivity (asymptomatics) is unknown. We carried out a systematic review of availa…
View article: SARS-CoV-2 and the role of vertical transmission from infected pregnant women to their fetuses: systematic review.
SARS-CoV-2 and the role of vertical transmission from infected pregnant women to their fetuses: systematic review. Open
Background Vertical transmission of SARS-CoV-2 has been reported but does not appear to be common. This study aims to systematically review the evidence for vertical transmission of SARS-CoV-2. Methods This review is part of an Open Eviden…
View article: SARS-CoV-2 and the role of fomite transmission: a systematic review
SARS-CoV-2 and the role of fomite transmission: a systematic review Open
Background:SARS-CoV-2 RNA has been detected in fomites which suggests the virus could be transmitted via inanimate objects. However, there is uncertainty about the mechanistic pathway for such transmissions. Our objective was to identify, …