Jon Christensen
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An Analysis of Training of the Remote Medical Provider and Recommended Standards Open
This article summarizes the mindset, educational requirements, different training aspects, and specific treatment protocols that help establish the Remote Medical Provider (RMP) concept's baseline proficiency criteria and recommended insti…
Development Fees and Park Equity in Los Angeles Open
Parks are inequitably distributed in many U.S. cities, and policies and planning initiatives around the country have sought to rectify these inequities. In this study, we examined whether one such initiative, a policy change in development…
Multispecies Justice in the Wetlands Open
This essay discusses the rise of "justice" as a central concept around which environmental thought and debates have been organized over the last thirty years, and briefly places the notions of environmental justice and multispecies justice…
Comparison of [11C]-PBR28 Binding Between Persons Living With HIV and HIV-Uninfected Individuals Open
Objective: Despite combined antiretroviral therapy, neuroinflammation may persist in persons living with HIV (PLWH) and contribute to cognitive impairment in this population. Positron emission tomography (PET) imaging targeting 18 kDa tran…
P4‐268: QUANTIFYING OFF‐TARGET SKULL BINDING IN TAU PET STUDIES USING A CT‐BASED MASK Open
Previous reports with [18F]flortaucipir have addressed off-target binding in the choroid plexus and basal ganglia; anecdotal reports of off-target skull binding have been noted but minimally discussed. We attempt to evaluate off-target sku…
View article: Tau positron emission tomography imaging in C9orf72 repeat expansion carriers
Tau positron emission tomography imaging in C9orf72 repeat expansion carriers Open
Background and purpose AV ‐1451 ( 18 F‐ AV ‐1451, flortaucipir) positron emission tomography was performed in C9orf72 expansion carriers to assess tau accumulation and disease manifestation. Methods Nine clinically characterized C9orf72 ex…
View article: Assessing the flow to low-income urban areas of conservation and environmental funds approved by California’s Proposition 84
Assessing the flow to low-income urban areas of conservation and environmental funds approved by California’s Proposition 84 Open
Government funding accounts for a large proportion of conservation and environmental improvements, and is often the result of citizen votes on state ballot measures. A key concern surrounding public investments in the environment is whethe…
Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers Open
Tauopathy is a hallmark pathology of Alzheimer's disease with a strong relationship with cognitive impairment. As such, understanding tau may be a key to clinical interventions. In vivo tauopathy has been measured using cerebrospinal fluid…
Strategic Communication to Achieve Carbon Neutrality within the University of California Open
Author(s): Bales, Roger; Christensen, Jon; Heeren, Alex; Hodges, Heather; Leombruni, Lisa; Rebich-Hespanha, Stacy
IC‐P‐204: THE RELATIONSHIP BETWEEN TAU PET AND OTHER AD BIOMARKERS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE Open
Peer Reviewed
P3‐401: EXAMINING THE ABILITY OF A TAU SPATIAL SPREAD METRIC TO INDICATE DISEASE PROGRESSION COMPARED TO AN INTENSITY‐BASED APPROACH Open
Tau positron emission tomography (PET) is a marker of disease progression in AD that is highly correlated with levels of beta-amyloid, grey matter decline, and cognitive dysfunction. Previously we developed a summary region set (tau index,…
O3‐13‐03: THE RELATIONSHIP BETWEEN TAU PET AND OTHER AD BIOMARKERS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE Open
In autosomal dominant Alzheimer disease (ADAD), there is a conservation of age of symptom onset within families. This consistency allows participants to be staged according to their estimated years to symptom onset (EYO). This provides an …
Loss of white matter integrity reflects tau accumulation in Alzheimer disease defined regions Open
Tau, not Aβ, was associated with changes in anterior temporal WM integrity. WMH, a proxy for vascular damage, was strongly associated with axonal damage, but tau independently contributed to the model, suggesting an additional degenerative…
[P4–244]: WHITE MATTER INTEGRITY REFLECTS TAU ACCUMULATION IN AD‐DEFINED REGIONS Open
Axonal loss and demyelination are pathological changes that co-occur in Alzheimer disease (AD). Diffusion tensor imaging (DTI) is sensitive at detecting white matter degeneration in AD with changes more pronounced at later stages of the di…
[IC‐P‐054]: EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: RESULTS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK Open
Peer Reviewed
[P1–422]: RELATIONSHIP BETWEEN TAU POSITRON EMISSION TOMOGRAPHY WITH [18F]‐AV‐1451 AND LONGITUDINAL CORTICAL ATROPHY IN ALZHEIMER DISEASE Open
Neurofibrillary tau pathology is a marker of neurodegeneration and can be evaluated using the PET tracer [18F]-AV-1451 (flortaucipir, T807). Many studies have added tau imaging to ongoing longitudinal cohorts. We wanted to evaluate whether…
[O1–02–03]: EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: FINDINGS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK Open
Peer Reviewed
[P1–008]: RELATIONSHIP BETWEEN TAU POSITRON EMISSION TOMOGRAPHY WITH [18F]‐AV‐1451 AND LONGITUDINAL CORTICAL ATROPHY IN ALZHEIMER DISEASE Open
Neurofibrillary tau pathology is a marker of neurodegeneration and can be evaluated using the PET tracer [18F]-AV-1451 (flortaucipir, T807). Many studies have added tau imaging to ongoing longitudinal cohorts. We wanted to evaluate whether…
[IC‐P‐061]: APOE4 EFFECT ON LONGITUDINAL VOLUMETRICS AND PIB ACCUMULATION IN PRECLINICAL ALZHEIMER DISEASE Open
The e4 allele of apolipoprotein E (apoe4) is associated with increased risk of developing Alzheimer disease (AD). The purpose this study is to evaluate the effects of the e4 allele on longitudinal changes in cortical thickness, volume, and…
Gelatin device for the delivery of growth factors involved in endochondral ossification Open
Controlled release drug delivery systems are well established as oral and implantable dosage forms. However, the controlled release paradigm can also be used to present complex soluble signals responsible for cellular organization during d…
View article: Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia
Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia Open
Background: Flortaucipir (tau) positron emission tomography (PET) binding distinguishes individuals with clinically well-established posterior cortical atrophy (PCA) due to Alzheimer disease (AD) from cognitively normal (CN) controls. Howe…
Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group Open
[This corrects the article DOI: 10.1371/journal.pone.0152082.].
Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy Open
Use of [18F]-AV-1451 has a potential for staging of the preclinical and clinical phases of AD. β-Amyloid interacts with hippocampal and cortical tauopathy to affect neurodegeneration. In the absence of Aβ, hippocampal tau deposition may be…
IC‐01‐03: Classifying TAU Pet Positivity With [18F]‐AV‐1451 in Preclinical Alzheimer's Disease Open
[18F]-AV-1451 is a PET tracer used to evaluation of neurofibrillary tau pathology in vivo. It is still unknown what spatial pattern best characterizes an Alzheimer's signature of tau PET uptake in the brain. The objective of this study was…
P1‐263: Relating PET and CSF Measure of TAU Pathology Open
The two primary pathologies in Alzheimer disease are the aggregation of beta-amyloid into plaques and of tau into neurofibrillary tangles. Quantifications of these pathologies in vivo have been restricted to cerebrospinal fluid (CSF) assay…