Jon E. Tyson
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View article: Time to Full Enteral Feeds and Late-Onset Sepsis in Extremely Preterm Infants
Time to Full Enteral Feeds and Late-Onset Sepsis in Extremely Preterm Infants Open
Importance Recent studies suggest that early achievement of full enteral feeding improves clinical outcomes among preterm infants. Objective To examine the association between full enteral feeding and late-onset sepsis. Design, Setting, an…
View article: Data harmonization framework for neonatal hypoxic-ischemic encephalopathy studies
Data harmonization framework for neonatal hypoxic-ischemic encephalopathy studies Open
Objectives To develop a data harmonization framework for neonatal hypoxic-ischemic encephalopathy (HIE) studies and demonstrate its suitability for prognostic biomarker development. Materials and Methods Variables were first categorized by…
View article: Individualizing NSAID therapy in axial spondyloarthritis: N-of-1 trials with Bayesian analysis
Individualizing NSAID therapy in axial spondyloarthritis: N-of-1 trials with Bayesian analysis Open
Objective Axial spondyloarthritis (axSpA) is a chronic inflammatory disease predominantly affecting the spine and sacroiliac joints. NSAIDs are first-line therapy, but individual responses vary widely. We evaluated the efficacy and patient…
View article: Respiratory Outcomes After Transcatheter vs Surgical Patent Ductus Arteriosus Closure in Preterm Infants
Respiratory Outcomes After Transcatheter vs Surgical Patent Ductus Arteriosus Closure in Preterm Infants Open
Importance Transcatheter closure of the patent ductus arteriosus (PDA) has increasingly been adopted in extremely preterm infants as a method to definitively close the PDA while avoiding the inherent risks of surgical ligation. Differences…
View article: Do Medicaid Data Accurately Reflect the Expenditures and Outcomes for Extremely Premature Infants?
Do Medicaid Data Accurately Reflect the Expenditures and Outcomes for Extremely Premature Infants? Open
The accurate and meaningful assessment of Medicaid expenditures relative to survival rates among Medicaid-eligible extremely premature infants has received little scrutiny, despite its importance for improving outcomes. We have identified …
View article: Extended Caffeine for Apnea in Moderately Preterm Infants
Extended Caffeine for Apnea in Moderately Preterm Infants Open
Importance Hospitalization of moderately preterm infants may be prolonged while waiting for apnea of prematurity to resolve after discontinuing caffeine. Objective To evaluate whether extending caffeine treatment reduces the duration of ho…
View article: Short Duration of Antenatal Corticosteroid Exposure and Outcomes in Extremely Preterm Infants
Short Duration of Antenatal Corticosteroid Exposure and Outcomes in Extremely Preterm Infants Open
Importance When preterm delivery is imminent, it remains unclear whether the timing from administration of antenatal betamethasone to birth may reduce mortality and morbidity among extremely preterm infants. Objective To evaluate the assoc…
View article: Cerebral injury and retinopathy as risk factors for blindness in extremely preterm infants
Cerebral injury and retinopathy as risk factors for blindness in extremely preterm infants Open
Objective This study investigates whether and to what extent cerebral injury is associated with bilateral blindness in extremely preterm infants, which has been attributed mainly to retinopathy of prematurity (ROP). Design Multicentre anal…
View article: Randomized controlled trial of enteral vitamin D supplementation (ViDES) in infants <28 weeks gestational age or <1000 g birth weight: study protocol
Randomized controlled trial of enteral vitamin D supplementation (ViDES) in infants <28 weeks gestational age or <1000 g birth weight: study protocol Open
Background Vitamin D is necessary to develop healthy lungs and other organs early in life. Most infants born before 28 weeks’ gestation have low vitamin D levels at birth and a limited intake during the first month. Enteral vitamin D suppl…
View article: Randomized Controlled Trial of Enteral Vitamin D Supplementation (ViDES) in Infants &lt;28 Weeks Gestational Age or &lt;1000 Grams Birth Weight: Study Protocol
Randomized Controlled Trial of Enteral Vitamin D Supplementation (ViDES) in Infants <28 Weeks Gestational Age or <1000 Grams Birth Weight: Study Protocol Open
Background Vitamin D is necessary to develop healthy lungs and other organs early in life. Most infants born before 28 weeks’ gestation have low vitamin D levels at birth and a limited intake during the first month. Enteral vitamin D suppl…
View article: Surgical Necrotizing Enterocolitis and Spontaneous Intestinal Perforation Lead to Severe Growth Failure in Infants
Surgical Necrotizing Enterocolitis and Spontaneous Intestinal Perforation Lead to Severe Growth Failure in Infants Open
Objective: We aimed to determine the incidence of growth failure in infants with necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP) and whether initial laparotomy versus peritoneal drainage (PD) impacted the likeli…
View article: Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis
Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis Open
Importance Observational studies often report that anemia and red blood cell (RBC) transfusions are associated with a higher risk of necrotizing enterocolitis (NEC) among extremely low-birthweight (ELBW) infants. Objective To evaluate whet…
View article: Effect of Early vs Late Inguinal Hernia Repair on Serious Adverse Event Rates in Preterm Infants
Effect of Early vs Late Inguinal Hernia Repair on Serious Adverse Event Rates in Preterm Infants Open
Importance Inguinal hernia repair in preterm infants is common and is associated with considerable morbidity. Whether the inguinal hernia should be repaired prior to or after discharge from the neonatal intensive care unit is controversial…
View article: Social distancing and extremely preterm births in the initial COVID-19 pandemic period
Social distancing and extremely preterm births in the initial COVID-19 pandemic period Open
Hypothesis Increased social distancing was associated with a lower incidence of extremely preterm live births (EPLB) during the initial COVID-19 pandemic period. Study design Prospective study at the NICHD Neonatal Research Network sites c…
View article: Hospital-Level NICU Capacity, Utilization, and 30-Day Outcomes in Texas
Hospital-Level NICU Capacity, Utilization, and 30-Day Outcomes in Texas Open
Importance Risk-adjusted neonatal intensive care unit (NICU) utilization and outcomes vary markedly across regions and hospitals. The causes of this variation are poorly understood. Objective To assess the association of hospital-level NIC…
View article: Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula
Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula Open
Importance Maternal milk feeding of extremely preterm infants during the birth hospitalization has been associated with better neurodevelopmental outcomes compared with preterm formula. For infants receiving no or minimal maternal milk, it…
View article: Evaluation of negative binomial and zero-inflated negative binomial models for the analysis of zero-inflated count data: application to the telemedicine for children with medical complexity trial
Evaluation of negative binomial and zero-inflated negative binomial models for the analysis of zero-inflated count data: application to the telemedicine for children with medical complexity trial Open
Background Two characteristics of commonly used outcomes in medical research are zero inflation and non-negative integers; examples include the number of hospital admissions or emergency department visits, where the majority of patients wi…
View article: Automated Large Vessel Occlusion Detection Software and Thrombectomy Treatment Times
Automated Large Vessel Occlusion Detection Software and Thrombectomy Treatment Times Open
Importance The benefit of endovascular stroke therapy (EVT) in large vessel occlusion (LVO) ischemic stroke is highly time dependent. Process improvements to accelerate in-hospital workflows are critical. Objective To determine whether aut…
View article: Heterogeneity of Treatment Effects of Hydrocortisone by Risk of Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants in the National Institute of Child Health and Human Development Neonatal Research Network Trial
Heterogeneity of Treatment Effects of Hydrocortisone by Risk of Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants in the National Institute of Child Health and Human Development Neonatal Research Network Trial Open
Importance Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are at a higher risk for adverse pulmonary and neurodevelopmental outcomes. In the National Institute of Child Health and Human Development Neonatal Research…
View article: Assessment of Corticosteroid Therapy and Death or Disability According to Pretreatment Risk of Death or Bronchopulmonary Dysplasia in Extremely Preterm Infants
Assessment of Corticosteroid Therapy and Death or Disability According to Pretreatment Risk of Death or Bronchopulmonary Dysplasia in Extremely Preterm Infants Open
Importance Meta-analyses suggest that corticosteroids may be associated with increased survival without cerebral palsy in infants at high risk of bronchopulmonary dysplasia (BPD) but are associated with adverse neurologic outcomes in low-r…
View article: Effect of Reduced Versus Usual Lipid Emulsion Dosing on Bilirubin Neurotoxicity and Neurodevelopmental Impairment in Extremely Preterm Infants: Study Protocol for a Randomized Controlled Trial
Effect of Reduced Versus Usual Lipid Emulsion Dosing on Bilirubin Neurotoxicity and Neurodevelopmental Impairment in Extremely Preterm Infants: Study Protocol for a Randomized Controlled Trial Open
Background : Bilirubin neurotoxicity ( BN ) occurs in premature infants at lower total serum bilirubin levels than term infants and causes neurodevelopmental impairment. Usual dose lipid infusions in preterm infants may increase free fatty…