Jon Huyghe
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View article: Virotrap Reveals <i>Salmonella</i> SopB as A Ubiquitinated Cargo for Host ESCRT-0
Virotrap Reveals <i>Salmonella</i> SopB as A Ubiquitinated Cargo for Host ESCRT-0 Open
The pathogenic bacterium Salmonella survives and replicates in host cells within a Salmonella -containing vacuole (SCV). To build this niche, Salmonella uses secreted effectors, such as SopB, a phosphoinositide phosphotransferase that modi…
View article: NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis
NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis Open
View article: Cell death checkpoints in the TNF pathway
Cell death checkpoints in the TNF pathway Open
View article: LC3-independent autophagy is vital to prevent TNF cytotoxicity
LC3-independent autophagy is vital to prevent TNF cytotoxicity Open
The (macro)autophagy field is facing a paradigm shift after the recent discovery that cytosolic cargoes can still be selectively targeted to phagophores (the precursors to autophagosomes) even in the absence of LC3 or other Atg8-protein fa…
View article: ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway
ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway Open
Cell death induced by tumor necrosis factor (TNF) can be beneficial during infection by helping to mount proper immune responses. However, TNF-induced death can also drive a variety of inflammatory pathologies. Protectives brakes, or cell-…
View article: Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor
Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor Open