Jon J. Ramsey
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View article: Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer
Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer Open
Introduction The ketogenic diet (KD) increases mouse lifespan and health span, and improves late-life memory. This raises the question regarding the mechanism behind this effect. In mice on a KD, blood beta-hydroxybutyrate (BHB) levels uni…
View article: Light and sex modify <i>Snord116</i> genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment
Light and sex modify <i>Snord116</i> genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment Open
Summary Mammals utilize imprinted and X-linked epigenetic mechanisms in development, metabolism, and behavior. Imprinted genes, including Prader-Willi syndrome Snord116 noncoding RNAs, are implicated in the regulation of sleep and circadia…
View article: Differential effects of short-term and long-term ketogenic diet on gene expression in the aging mouse brain
Differential effects of short-term and long-term ketogenic diet on gene expression in the aging mouse brain Open
This work informs target identification efforts for aging and neurodegenerative disorder therapeutics discovery while also establishing differential effects of short-term vs long-term KD on gene expression in the brain.
View article: The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats
The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats Open
Studies suggest that ketogenic diets (KD) may improve memory in mouse models of aging and Alzheimer's disease (AD). This study determined whether a continuous or intermittent KD (IKD) enhanced cognitive behavior in the TgF344-AD rat model …
View article: Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer’s mouse model and stimulates synaptic plasticity pathway enzymes
Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer’s mouse model and stimulates synaptic plasticity pathway enzymes Open
View article: When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging Open
View article: Data from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice
Data from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice Open
Pancreatic ductal adenocarcinoma (PDAC) continues to be a major health problem. A ketogenic diet (KD), characterized by a very low carbohydrate and high fat composition, has gained attention for its antitumor potential. We evaluated the ef…
View article: Supplementary Table S1, Figures S1-S8 from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice
Supplementary Table S1, Figures S1-S8 from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice Open
Supplementary Table S1. Experimental diets composition. Supplementary Figure S1. A ketogenic diet plus gemcitabine extends median overall survival in KPC mice. Supplementary Figure S2. Histopathological analysis of necrosis (C) in pancreat…
View article: Supplementary Table S1, Figures S1-S8 from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice
Supplementary Table S1, Figures S1-S8 from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice Open
Supplementary Table S1. Experimental diets composition. Supplementary Figure S1. A ketogenic diet plus gemcitabine extends median overall survival in KPC mice. Supplementary Figure S2. Histopathological analysis of necrosis (C) in pancreat…
View article: Data from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice
Data from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice Open
Pancreatic ductal adenocarcinoma (PDAC) continues to be a major health problem. A ketogenic diet (KD), characterized by a very low carbohydrate and high fat composition, has gained attention for its antitumor potential. We evaluated the ef…
View article: Data from Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor
Data from Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor Open
Breast cancer remains the most common malignant disease in women worldwide. Despite advances in detection and therapies, studies are still needed to understand the mechanisms underlying this cancer. Cancer stem cells (CSC) play an importan…
View article: Supplementary Figures 1-10 from Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor
Supplementary Figures 1-10 from Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor Open
S1. RUNX1 mRNA is decreased during breast cancer progression. S2. RUNX1 does not change cell proliferation. S3. RUNX1 represses tumor growth in mammary fat pad. S4. Gate for MCF10AT1 sorting. S5. CD24high Cells have high RUNX1 expression i…
View article: Supplementary Figures 1-10 from Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor
Supplementary Figures 1-10 from Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor Open
S1. RUNX1 mRNA is decreased during breast cancer progression. S2. RUNX1 does not change cell proliferation. S3. RUNX1 represses tumor growth in mammary fat pad. S4. Gate for MCF10AT1 sorting. S5. CD24high Cells have high RUNX1 expression i…
View article: Data from Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor
Data from Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor Open
Breast cancer remains the most common malignant disease in women worldwide. Despite advances in detection and therapies, studies are still needed to understand the mechanisms underlying this cancer. Cancer stem cells (CSC) play an importan…
View article: Ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice
Ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice Open
View article: Correction: A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice
Correction: A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice Open
[This corrects the article DOI: 10.1158/2767-9764.CRC-22-0256.][This corrects the article DOI: 10.1158/2767-9764.CRC-22-0256.].
View article: INTERMITTENT KETOGENIC DIETS EXTEND LIFESPAN AND ATTENUATE INFLAMMAGING IN MALE MICE
INTERMITTENT KETOGENIC DIETS EXTEND LIFESPAN AND ATTENUATE INFLAMMAGING IN MALE MICE Open
A ketogenic diet (KD) has been shown to increase functional lifespan in male mice when fed isocalorically to a control diet (CD). However, it is not clear if intermittent ketogenic diets (IKD) that induce brief and recurring periods of ket…
View article: 2‐month ketogenic diet preferentially alters skeletal muscle and augments cognitive function in middle aged female mice
2‐month ketogenic diet preferentially alters skeletal muscle and augments cognitive function in middle aged female mice Open
The effect of a ketogenic diet (KD) on middle aged female mice is poorly understood as most of this work have been conducted in young female mice or diseased models. We have previously shown that an isocaloric KD started at middle age in m…
View article: A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice
A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice Open
Pancreatic ductal adenocarcinoma (PDAC) continues to be a major health problem. A ketogenic diet (KD), characterized by a very low carbohydrate and high fat composition, has gained attention for its antitumor potential. We evaluated the ef…
View article: Long-term ketogenic diet increases expression of SOX2-dependent oligodendrocyte- and myelination-associated genes in the aged mouse brain
Long-term ketogenic diet increases expression of SOX2-dependent oligodendrocyte- and myelination-associated genes in the aged mouse brain Open
Aging is associated with multiple neurodegenerative conditions that severely limit quality of life and shorten lifespan. Studies in rodents indicate that in addition to extending lifespan, the ketogenic diet improves cognitive function in …
View article: The Histone H3 K4me3, K27me3, and K27ac Genome-Wide Distributions Are Differently Influenced by Sex in Brain Cortexes and Gastrocnemius of the Alzheimer’s Disease PSAPP Mouse Model
The Histone H3 K4me3, K27me3, and K27ac Genome-Wide Distributions Are Differently Influenced by Sex in Brain Cortexes and Gastrocnemius of the Alzheimer’s Disease PSAPP Mouse Model Open
Background: Women represent the majority of Alzheimer’s disease patients and show typical symptoms. Genetic, hormonal, and behavioral mechanisms have been proposed to explain sex differences in dementia prevalence. However, whether sex dif…
View article: A 1-Month Ketogenic Diet Increased Mitochondrial Mass in Red Gastrocnemius Muscle, but Not in the Brain or Liver of Middle-Aged Mice
A 1-Month Ketogenic Diet Increased Mitochondrial Mass in Red Gastrocnemius Muscle, but Not in the Brain or Liver of Middle-Aged Mice Open
Alterations in markers of mitochondrial content with ketogenic diets (KD) have been reported in tissues of rodents, but morphological quantification of mitochondrial mass using transmission electron microscopy (TEM), the gold standard for …
View article: A ketogenic diet impacts markers of mitochondrial mass in a tissue specific manner in aged mice
A ketogenic diet impacts markers of mitochondrial mass in a tissue specific manner in aged mice Open
Declines in mitochondrial mass are thought to be a hallmark of mammalian aging, and a ketogenic diet (KD) may prevent the age-related decreases in mitochondrial content. The objective of this study was to investigate the impact of a KD on …
View article: The ketogenic diet preserves skeletal muscle with aging in mice
The ketogenic diet preserves skeletal muscle with aging in mice Open
The causes of the decline in skeletal muscle mass and function with age, known as sarcopenia, are poorly understood. Nutrition (calorie restriction) interventions impact many cellular processes and increase lifespan and preserve muscle mas…
View article: Diet composition analysis provides new management insights for a highly specialized endangered small mammal
Diet composition analysis provides new management insights for a highly specialized endangered small mammal Open
The critically endangered Amargosa vole (Microtus californicus scirpensis) is found only in rare marsh habitat near Tecopa, California in a plant community dominated by three-square bulrush (Schoenoplectus americanus). Since the earliest r…
View article: Sex‐specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia‐susceptible mice
Sex‐specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia‐susceptible mice Open
Malignant hyperthermia (MH) is characterized by induction of skeletal muscle hyperthermia in response to a dysregulated increase in myoplasmic calcium. Although altered energetics play a central role in MH, MH‐susceptible humans and mouse …
View article: A big-data approach to understanding metabolic rate and response to obesity in laboratory mice
A big-data approach to understanding metabolic rate and response to obesity in laboratory mice Open
Maintaining a healthy body weight requires an exquisite balance between energy intake and energy expenditure. To understand the genetic and environmental factors that contribute to the regulation of body weight, an important first step is …
View article: Author response: A big-data approach to understanding metabolic rate and response to obesity in laboratory mice
Author response: A big-data approach to understanding metabolic rate and response to obesity in laboratory mice Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Maintaining a healthy body we…
View article: Sex differences in response to short-term high fat diet in mice
Sex differences in response to short-term high fat diet in mice Open
View article: Nonphagocytic Activation of NOX2 Is Implicated in Progressive Nonalcoholic Steatohepatitis During Aging
Nonphagocytic Activation of NOX2 Is Implicated in Progressive Nonalcoholic Steatohepatitis During Aging Open
Background and Aims Older patients with obesity/type II diabetes mellitus frequently present with advanced NASH. Whether this is due to specific molecular pathways that accelerate fibrosis during aging is unknown. Activation of the Src hom…