Jon K. Chen
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View article: Nanoscale analysis of human G1 and metaphase chromatin<i>in situ</i>
Nanoscale analysis of human G1 and metaphase chromatin<i>in situ</i> Open
The structure of chromatin at the nucleosome level inside cells is mysterious. Here we present in situ electron cryotomography analyses of chromatin in both G1 and metaphase RPE-1 cells. G1 nucleosomes are concentrated in globular chromati…
View article: Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ
Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ Open
Nuclear processes depend on the organization of chromatin, whose basic units are cylinder-shaped complexes called nucleosomes. A subset of mammalian nucleosomes in situ (inside cells) resembles the canonical structure determined in vitro 2…
View article: Author Response: Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ
Author Response: Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ Open
Nuclear processes depend on the organization of chromatin, whose basic units are cylinder-shaped complexes called nucleosomes. A subset of mammalian nucleosomes in situ (inside cells) resembles the canonical structure determined in vitro 2…
View article: Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ
Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ Open
Summary Nuclear processes depend on the organization of chromatin, whose basic units are cylinder-shaped complexes called nucleosomes. A subset of mammalian nucleosomes in situ (inside cells) resembles the canonical structure determined in…
View article: Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ
Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ Open
Nuclear processes depend on the organization of chromatin, whose basic units are cylinder-shaped complexes called nucleosomes. A subset of mammalian nucleosomes in situ (inside cells) resembles the canonical structure determined in vitro 2…
View article: Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ
Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ Open
Summary Nuclear processes depend on the organization of chromatin, whose basic units are cylinder-shaped complexes called nucleosomes. A subset of mammalian nucleosomes in situ (inside cells) resembles the canonical structure determined in…
View article: Author Response: Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ
Author Response: Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ Open
Nuclear processes depend on the organization of chromatin, whose basic units are cylinder-shaped complexes called nucleosomes. A subset of mammalian nucleosomes in situ (inside cells) resembles the canonical structure determined in vitro 2…
View article: Heterogeneous non-canonical nucleosomes predominate in yeast cells <i>in situ</i>
Heterogeneous non-canonical nucleosomes predominate in yeast cells <i>in situ</i> Open
SUMMARY Nuclear processes depend on the organization of chromatin, whose basic units are cylinder-shaped complexes called nucleosomes. A subset of mammalian nucleosomes in situ (inside cells) resembles the canonical structure determined in…
View article: The Interaction of the Metallo-Glycopeptide Anti-Tumour Drug Bleomycin with DNA
The Interaction of the Metallo-Glycopeptide Anti-Tumour Drug Bleomycin with DNA Open
The cancer chemotherapeutic drug, bleomycin, is clinically used to treat several neoplasms including testicular and ovarian cancers. Bleomycin is a metallo-glycopeptide antibiotic that requires a transition metal ion, usually Fe(II), for a…
View article: Enhancement of tendon–bone healing via the combination of biodegradable collagen-loaded nanofibrous membranes and a three-dimensional printed bone-anchoring bolt
Enhancement of tendon–bone healing via the combination of biodegradable collagen-loaded nanofibrous membranes and a three-dimensional printed bone-anchoring bolt Open
Ying-Chao Chou,1,2 Wen-Lin Yeh,2 Chien-Lin Chao,1 Yung-Heng Hsu,1,2 Yi-Hsun Yu,1,2 Jan-Kan Chen,3 Shih-Jung Liu1,2 1Department of Mechanical Engineering, Chang Gung University, 2Department of Orthopedic Surgery, Chang Gung Memorial Hospita…
View article: Characterization of pulmonary protein profiles in response to zinc oxide nanoparticles in mice: a 24-hour and 28-day follow-up study
Characterization of pulmonary protein profiles in response to zinc oxide nanoparticles in mice: a 24-hour and 28-day follow-up study Open
Chih-Hong Pan,1,2,* Kai-Jen Chuang,3,4,* Jen-Kun Chen,5 Ta-Chih Hsiao,6 Ching-Huang Lai,2 Tim P Jones,7 Kelly A BéruBé,8 Gui-Bing Hong,9 Kin-Fai Ho,10,11 Hsiao-Chi Chuang12,13 1Institute of Occupational Safety and Health, Council of Labor …