Jon Laye
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View article: Tumour-Infiltrating Lymphocytes, Tumour Cell Density, and Response to Neoadjuvant Short-Course Radiotherapy in Rectal Cancer: A Translational Sub-Study from the MRC CR07 Clinical Trial
Tumour-Infiltrating Lymphocytes, Tumour Cell Density, and Response to Neoadjuvant Short-Course Radiotherapy in Rectal Cancer: A Translational Sub-Study from the MRC CR07 Clinical Trial Open
Background: Rectal cancer is common and frequently treated with neoadjuvant radiotherapy prior to surgery to reduce the risk of tumour recurrence. However, the therapeutic benefits and side effects of radiotherapy can vary between patients…
Deep-learning enabled combined measurement of tumour cell density and tumour infiltrating lymphocyte density as a prognostic biomarker in colorectal cancer Open
Background Within the colorectal cancer (CRC) tumour microenvironment, tumour infiltrating lymphocytes (TILs) and tumour cell density (TCD) are recognised prognostic markers. Measurement of TILs and TCD using deep-learning (DL) on haematox…
View article: Systemic Inflammation, the Peripheral Blood Transcriptome, and Primary Melanoma
Systemic Inflammation, the Peripheral Blood Transcriptome, and Primary Melanoma Open
Peripheral blood transcriptomes from 383 patients with newly diagnosed melanoma were subjected to differential gene expression analysis. The hypotheses were that impaired systemic immunity is associated with poorer prognosis (thicker tumor…
View article: Ulcerated melanoma: Systems biology evidence of inflammatory imbalance towards pro‐tumourigenicity
Ulcerated melanoma: Systems biology evidence of inflammatory imbalance towards pro‐tumourigenicity Open
Microscopic ulceration is an independent predictor of melanoma death. Here, we used systems biology to query the role of host and tumour‐specific processes in defining the phenotype. Albumin level as a measure of systemic inflammation was …
High-Resolution Copy Number Patterns From Clinically Relevant FFPE Material Open
Systematic tumour profiling is essential for biomarker research and clinically for assessing response to therapy. Solving the challenge of delivering informative copy number (CN) profiles from formalin-fixed paraffin embedded (FFPE) materi…
View article: β-Catenin–mediated immune evasion pathway frequently operates in primary cutaneous melanomas
β-Catenin–mediated immune evasion pathway frequently operates in primary cutaneous melanomas Open
Immunotherapy prolongs survival in only a subset of melanoma patients, highlighting the need to better understand the driver tumor microenvironment. We conducted bioinformatic analyses of 703 transcriptomes to probe the immune landscape of…