Jon Olav Vik
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View article: A hierarchy of metabolite exchanges in metabolic models of microbial species and communities
A hierarchy of metabolite exchanges in metabolic models of microbial species and communities Open
The metabolic network of an organism can be analyzed as a constraint-based model. This analysis can be biased, optimizing an objective such as growth rate, or unbiased, aiming to describe the full feasible space of metabolic fluxes through…
View article: Evaluating sustainable feeds for aquaculture by simulating Atlantic salmon lipid metabolism
Evaluating sustainable feeds for aquaculture by simulating Atlantic salmon lipid metabolism Open
Atlantic salmon aquaculture is an important food source globally, but its sustainability is challenged by environmental impacts and the nutritional demands of farmed fish, particularly when it comes to fatty acids. Salmon feeds still rely …
View article: The genome regulatory landscape of Atlantic salmon liver through smoltification
The genome regulatory landscape of Atlantic salmon liver through smoltification Open
The anadromous Atlantic salmon undergo a preparatory physiological transformation before seawater entry, referred to as smoltification. Key molecular developmental processes involved in this life stage transition, such as remodeling of gil…
View article: Predicting microbial genome-scale metabolic networks directly from 16S rRNA gene sequences
Predicting microbial genome-scale metabolic networks directly from 16S rRNA gene sequences Open
Genome-scale metabolic models are key biotechnology tools that can predict metabolic capabilities and growth for an organism. In particular, these models have become indispensable for metabolic analysis of microbial species and communities…
View article: Effect of Dietary Cholesterol, Phytosterol, and Docosahexaenoic Acid on Astaxanthin Absorption and Retention in Rainbow Trout
Effect of Dietary Cholesterol, Phytosterol, and Docosahexaenoic Acid on Astaxanthin Absorption and Retention in Rainbow Trout Open
Astaxanthin (Ax) determines the flesh redness of a salmonid fish which is the most desirable quality indicator by consumers. Fish cannot synthesize Ax de novo, therefore, the only way to increase flesh redness is to increase dietary input …
View article: A hierarchy of metabolite exchanges in metabolic models of microbial species and communities
A hierarchy of metabolite exchanges in metabolic models of microbial species and communities Open
The metabolic network of an organism can be analyzed as a constraint-based model. This analysis can be biased, optimizing an objective such as growth rate, or unbiased, aiming to describe the full feasible space of metabolic fluxes through…
View article: The genome regulatory landscape of Atlantic salmon liver through smoltification
The genome regulatory landscape of Atlantic salmon liver through smoltification Open
The anadromous Atlantic salmon undergo a preparatory physiological transformation before seawater entry, referred to as smoltification. Key molecular developmental processes involved in this life stage transition, such as remodeling of gil…
View article: Effect of dietary cholesterol, phytosterol, and docosahexaenoic acid on astaxanthin absorption and retention in rainbow trout
Effect of dietary cholesterol, phytosterol, and docosahexaenoic acid on astaxanthin absorption and retention in rainbow trout Open
Astaxanthin (Ax) determines the flesh redness of a salmonid fish which is the most desirable quality indicator by consumers. Fish cannot synthesize Ax de novo , therefore the only way to increase flesh redness is to increase dietary input …
View article: Extracting functionally accurate context-specific models of Atlantic salmon metabolism
Extracting functionally accurate context-specific models of Atlantic salmon metabolism Open
Constraint-based models (CBMs) are used to study metabolic network structure and function in organisms ranging from microbes to multicellular eukaryotes. Published CBMs are usually generic rather than context-specific, meaning that they do…
View article: Extracting functionally accurate context-specific models of Atlantic salmon metabolism
Extracting functionally accurate context-specific models of Atlantic salmon metabolism Open
Constraint-based models (CBMs) are used to study metabolic network structure and function in organisms ranging from microbes to multicellular eukaryotes. Published CBMs are usually generic rather than context-specific, meaning that they do…
View article: Transcriptomics data integration for context-specific modeling of Atlantic salmon metabolism: functional evaluation of methods based on metabolic tasks
Transcriptomics data integration for context-specific modeling of Atlantic salmon metabolism: functional evaluation of methods based on metabolic tasks Open
Motivation Constraint-based models (CBMs) are used to study the metabolic networks of organisms ranging from microbes to multicellular eukaryotes. Published CBMs are usually generic rather than context-specific, meaning that they do not ca…
View article: SALARECON connects the Atlantic salmon genome to growth and feed efficiency
SALARECON connects the Atlantic salmon genome to growth and feed efficiency Open
Atlantic salmon ( Salmo salar ) is the most valuable farmed fish globally and there is much interest in optimizing its genetics and rearing conditions for growth and feed efficiency. Marine feed ingredients must be replaced to meet global …
View article: SALARECON connects the Atlantic salmon genome to growth and feed efficiency
SALARECON connects the Atlantic salmon genome to growth and feed efficiency Open
Atlantic salmon ( Salmo salar ) is the most valuable farmed fish globally and there is much interest in optimizing its genetics and rearing conditions for growth and feed efficiency. Marine feed ingredients must be replaced to meet global …
View article: Diet and Life Stage-Associated Lipidome Remodeling in Atlantic Salmon
Diet and Life Stage-Associated Lipidome Remodeling in Atlantic Salmon Open
Salmon is an important source of long-chain highly unsaturated fatty acids (LC-HUFAs) such as 22:6n-3 [docosahexaenoic acid (DHA)]. In the present study, we conducted two identical experiments on salmon in freshwater (FW) and seawater (SW)…
View article: Comparative transcriptomics reveals domestication‐associated features of Atlantic salmon lipid metabolism
Comparative transcriptomics reveals domestication‐associated features of Atlantic salmon lipid metabolism Open
Domestication of animals imposes strong targeted selection for desired traits but can also result in unintended selection due to new domestic environments. Atlantic salmon ( Salmo salmar ) was domesticated in the 1970s and has subsequently…
View article: Targeted mutagenesis of Δ5 and Δ6 fatty acyl desaturases induce multiplex-mutagenesis and lipogenesis in Atlantic salmon (<i>Salmo salar</i>)
Targeted mutagenesis of Δ5 and Δ6 fatty acyl desaturases induce multiplex-mutagenesis and lipogenesis in Atlantic salmon (<i>Salmo salar</i>) Open
With declining wild fish populations, farmed Atlantic salmon ( Salmo salar ) has gained popularity as a source for healthy long-chain highly unsaturated fatty acids (LC-HUFA) including 20:5n-3 and 22:6n-3. However, the introduction of plan…
View article: Additional file 3 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar)
Additional file 3 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar) Open
(CSV 3 kb)
View article: Additional file 1 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar)
Additional file 1 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar) Open
(XLSX 608 kb)
View article: Additional file 2 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar)
Additional file 2 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar) Open
(CSV 61 kb)
View article: Comparative transcriptomics reveals domestication-associated features of Atlantic salmon lipid metabolism
Comparative transcriptomics reveals domestication-associated features of Atlantic salmon lipid metabolism Open
Domestication of Salmo salar has imposed strong selection for production traits since the 1970s. The domestication has also imposed a radical shift in diet. Whereas wild salmon eats invertebrates, crustaceans and fish, the dietary lipids i…
View article: Peer Review #2 of "Liver slice culture as a model for lipid metabolism in fish (v0.1)"
Peer Review #2 of "Liver slice culture as a model for lipid metabolism in fish (v0.1)" Open
Hepatic lipid metabolism is traditionally investigated in vitro using hepatocyte monocultures lacking the complex three-dimensional structure and interacting cell types essential liver function.Precision cut liver slice (PCLS) culture repr…
View article: Liver slice culture as a model for lipid metabolism in fish
Liver slice culture as a model for lipid metabolism in fish Open
Hepatic lipid metabolism is traditionally investigated in vitro using hepatocyte monocultures lacking the complex three-dimensional structure and interacting cell types essential liver function. Precision cut liver slice (PCLS) culture rep…
View article: Peer Review #1 of "Liver slice culture as a model for lipid metabolism in fish (v0.1)"
Peer Review #1 of "Liver slice culture as a model for lipid metabolism in fish (v0.1)" Open
Hepatic lipid metabolism is traditionally investigated in vitro using hepatocyte monocultures lacking the complex three-dimensional structure and interacting cell types essential liver function.Precision cut liver slice (PCLS) culture repr…
View article: Peer Review #2 of "Liver slice culture as a model for lipid metabolism in fish (v0.2)"
Peer Review #2 of "Liver slice culture as a model for lipid metabolism in fish (v0.2)" Open
Hepatic lipid metabolism is traditionally investigated in vitro using hepatocyte monocultures lacking the complex three-dimensional structure and interacting cell types essential liver function.Precision cut liver slice (PCLS) culture repr…