Jon Packham
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View article: A retrospective observational study of effectiveness of sequential biologic and targeted synthetic DMARDs in psoriatic arthritis in the UK
A retrospective observational study of effectiveness of sequential biologic and targeted synthetic DMARDs in psoriatic arthritis in the UK Open
Objectives Evidence evaluating effectiveness of biologic and targeted synthetic DMARDs (b/tsDMARDs) in adults with PsA after exposure to three or more b/tsDMARDs is lacking. We aimed to evaluate response to sequential lines of b/tsDMARDs. …
View article: Sexual function in axial spondyloarthritis: a systematic review and meta-analysis
Sexual function in axial spondyloarthritis: a systematic review and meta-analysis Open
Objectives This systematic review and meta-analysis examined how axial spondyloarthritis (axSpA), and its specific disease features, impact sexual function. Methods Systematic review of medical literature databases PsycINFO, CINAHL, MEDLIN…
View article: P181 Fatigue and mood disturbance in axial spondyloarthritis: identifying distinct patient clusters from a UK dataset
P181 Fatigue and mood disturbance in axial spondyloarthritis: identifying distinct patient clusters from a UK dataset Open
Background/Aims Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the axial skeleton and peripheral joints typically causing symptoms of back pain, disrupted sleep and widespread pain and stiffness. This life-long, progr…
View article: OA18 Measuring fatigue in axial spondyloarthritis: refinement and evaluation of the electronic version of the Warwick Axial Spondyloarthritis Fatigue and Energy questionnaire
OA18 Measuring fatigue in axial spondyloarthritis: refinement and evaluation of the electronic version of the Warwick Axial Spondyloarthritis Fatigue and Energy questionnaire Open
Background/Aims Axial spondyloarthritis (axSpA) is a chronic inflammatory condition of the axial skeleton and peripheral joints. Though typified by back pain and stiffness, disrupted sleep and fatigue are commonly experienced and ranked as…
View article: E096 Sexual function in axial spondyloarthritis: a systematic review and meta-analysis
E096 Sexual function in axial spondyloarthritis: a systematic review and meta-analysis Open
Background/Aims Sexual function is crucial for fostering intimate relationships and enhancing quality of life. The impact of axial spondyloarthritis (axSpA) on sexual function remains unclear despite existing research, which has typically …
View article: E067 It’s important the doctor knows me and my arthritis: exploring the experiences and needs of young people attending an adult rheumatology service
E067 It’s important the doctor knows me and my arthritis: exploring the experiences and needs of young people attending an adult rheumatology service Open
Background/Aims Young adults living with Juvenile Inflammatory Arthritis (JIA) and Inflammatory Arthritis (IA) have evolving needs related to their biopsychosocial development. Little is known about the experiences and needs of young adult…
View article: P069 The acceptability of ePROMs in the routine care of patients with inflammatory arthritis and its variation across patient groups: a mixed-methods study
P069 The acceptability of ePROMs in the routine care of patients with inflammatory arthritis and its variation across patient groups: a mixed-methods study Open
Background/Aims Electronic patient-reported outcome measures (ePROMs) can facilitate innovative, holistic care for people with inflammatory arthritis (IA). The crucial first step in their implementation is understanding their feasibility a…
View article: Identifying axial spondyloarthritis flares using the Evaluation of Ankylosing Spondylitis Quality of Life (EASiQoL) patient-reported outcome measure via an online portal: the FASTER study protocol
Identifying axial spondyloarthritis flares using the Evaluation of Ankylosing Spondylitis Quality of Life (EASiQoL) patient-reported outcome measure via an online portal: the FASTER study protocol Open
Background People with axial spondyloarthritis (axSpA) frequently experience increases in symptoms (flares) related to pain, stiffness and fatigue. Despite frequent use of the term ‘flare’ within axSpA, it is poorly defined and characteris…
View article: Psoriatic Arthritis Priority Setting Partnership: patient- and clinician-informed considerations for future UK health service delivery
Psoriatic Arthritis Priority Setting Partnership: patient- and clinician-informed considerations for future UK health service delivery Open
Objectives Little is known about the ideal service delivery model and shortcomings in patient experiences in the NHS for patients with psoriatic arthritis (PsA). The objective of this work was to identify unmet needs perceived within the c…
View article: Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT
Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT Open
Background Longitudinal observational studies suggest that patients who present early to secondary care with psoriatic arthritis have a better outcome. Outcome needs to be measured including domains important to patients. Objectives To ide…
View article: Granulocyte-macrophage colony-stimulating factor neutralisation in patients with axial spondyloarthritis in the UK (NAMASTE): a randomised, double-blind, placebo-controlled, phase 2 trial
Granulocyte-macrophage colony-stimulating factor neutralisation in patients with axial spondyloarthritis in the UK (NAMASTE): a randomised, double-blind, placebo-controlled, phase 2 trial Open
Izana Bioscience, NIHR Oxford Biomedical Research Centre (BRC), NIHR Birmingham BRC, and Clinical Research Facility.
View article: How do patient reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients
How do patient reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients Open
International audience
View article: How do patient-reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients
How do patient-reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients Open
Objectives The AsseSSing Impact in pSoriatic Treatment (ASSIST) study investigated prescribing in routine PsA care and whether the patient-reported outcome—PsA Impact of Disease questionnaire (PsAID-12)—impacted treatment. This study also …
View article: British Axial Spondyloarthritis Inception Cohort (BAxSIC): a protocol for a multicentre real-world observational cohort study of early axial spondyloarthritis
British Axial Spondyloarthritis Inception Cohort (BAxSIC): a protocol for a multicentre real-world observational cohort study of early axial spondyloarthritis Open
Objectives Timely diagnosis remains a challenge in axial SpA (axSpA). In addition, data are scarce on the impact of diagnostic delay and disease progression in affected individuals. The British Axial Spondyloarthritis Inception Cohort (BAx…
View article: A meta-analysis and systematic review of the use of transition tools for patients transitioning from paediatric to adult rheumatology services
A meta-analysis and systematic review of the use of transition tools for patients transitioning from paediatric to adult rheumatology services Open
Objectives Transitioning from paediatric to adult care can be challenging, but transition tools are designed to increase successful rates of transfer. We aimed to conduct a meta-analysis and systematic review of the use of transition tools…
View article: Psoriatic arthritis: the role of self-reported non-adherence, non-trough drug levels, immunogenicity and conventional synthetic DMARD co-therapy in adalimumab and etanercept response
Psoriatic arthritis: the role of self-reported non-adherence, non-trough drug levels, immunogenicity and conventional synthetic DMARD co-therapy in adalimumab and etanercept response Open
Objective The aim of this study was to assess the relationship between self-reported non-adherence, non-trough drug levels, immunogenicity and conventional synthetic DMARD (csDMARD) co-therapy in TNF inhibitor (TNF-i) drug response in PsA.…
View article: Non-trough serum drug levels of adalimumab and etanercept are associated with response in patients with psoriatic arthritis
Non-trough serum drug levels of adalimumab and etanercept are associated with response in patients with psoriatic arthritis Open
Objectives Up to 40% of PsA patients experience first-line tumour necrosis factor inhibitors (TNF-i) failure. Lower serum drug levels (SDL) have been associated with lower response in autoimmune conditions. This study aimed to: (i) establi…
View article: An international multicentre analysis of current prescribing practices and shared decision-making in psoriatic arthritis
An international multicentre analysis of current prescribing practices and shared decision-making in psoriatic arthritis Open
Objectives Shared decision-making (SDM) is advocated to improve patient outcomes in PsA. We analysed current prescribing practices and the extent of SDM in PsA across Europe. Methods The ASSIST study was a cross-sectional observational stu…
View article: The comparative performance of three screening questionnaires for psoriatic arthritis in a primary care surveillance study
The comparative performance of three screening questionnaires for psoriatic arthritis in a primary care surveillance study Open
Objectives The objective of this study was to compare the performance of three PsA screening questionnaires in a primary care psoriasis surveillance study. Methods Participants with psoriasis, and not known to have PsA, were identified fro…
View article: Socioeconomic deprivation is associated with reduced response and lower treatment persistence with TNF inhibitors in rheumatoid arthritis
Socioeconomic deprivation is associated with reduced response and lower treatment persistence with TNF inhibitors in rheumatoid arthritis Open
Objective To investigate the association between socioeconomic deprivation and outcomes following TNF inhibitor (TNFi) treatment. Methods Individuals commencing their first TNFi in the British Society for Rheumatology Biologics Register fo…
View article: AB1147 THE COMPARATIVE PERFORMANCE OF THREE SCREENING QUESTIONNAIRES FOR PSORIATIC ARTHRITIS IN A PRIMARY CARE SURVEILLANCE PROGRAM
AB1147 THE COMPARATIVE PERFORMANCE OF THREE SCREENING QUESTIONNAIRES FOR PSORIATIC ARTHRITIS IN A PRIMARY CARE SURVEILLANCE PROGRAM Open
Background There are considerable delays in the diagnosis of psoriatic arthritis (PsA) and earlier diagnosis is likely to lead to better outcomes. Objectives The aim of this study was to compare the performance of three PsA screening quest…
View article: Cost-effectiveness of cognitive behavioural and personalized exercise interventions for reducing fatigue in inflammatory rheumatic diseases
Cost-effectiveness of cognitive behavioural and personalized exercise interventions for reducing fatigue in inflammatory rheumatic diseases Open
Objectives To estimate the cost-effectiveness of a cognitive behavioural approach (CBA) or a personalized exercise programme (PEP), alongside usual care (UC), in patients with inflammatory rheumatic diseases who report chronic, moderate to…
View article: P174 Psoriatic arthritis patients in the UK have a lower quality of life than patients in mainland Europe - an analysis from the ASSIST study
P174 Psoriatic arthritis patients in the UK have a lower quality of life than patients in mainland Europe - an analysis from the ASSIST study Open
Background/Aims Psoriatic arthritis (PsA) is a heterogeneous, multi-dimensional disease. Treatment pathways are not well defined and have to be tailored to the individual; however, little is known about the factors underpinning a decision …
View article: P178 Current prescribing practices in psoriatic arthritis - comparison between the UK and Europe
P178 Current prescribing practices in psoriatic arthritis - comparison between the UK and Europe Open
Background/Aims Psoriatic arthritis (PsA) is a multi-system disease with a range of management options. Treatment may vary by geographic location. We compared disease characteristics and prescribing practices in the UK and Europe in the po…