Jon R. Inglefield
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View article: Initial Experience with CD19/CD22 BiCistronic CAR T-Cells in Children and Young Adults with Recurrent or Refractory B-Cell Malignancies
Initial Experience with CD19/CD22 BiCistronic CAR T-Cells in Children and Young Adults with Recurrent or Refractory B-Cell Malignancies Open
Introduction: Single-antigen targeted CAR T-cells have great efficacy in B-cell acute lymphoblastic leukemia (B-ALL), but immune escape is a significant cause of relapse. Dual antigen targeting represents a potential mechanism to improve d…
View article: 2349. Natural Killer Cells and BNT162b2 mRNA Vaccine Reactogenicity and Durability
2349. Natural Killer Cells and BNT162b2 mRNA Vaccine Reactogenicity and Durability Open
Background Natural killer (NK) cells can both amplify and diminish immune responses to vaccination. Studies in humans and animals have observed NK cell activation within days after mRNA vaccination. In this study, we sought to determine if…
View article: Natural killer cells and BNT162b2 mRNA vaccine reactogenicity and durability
Natural killer cells and BNT162b2 mRNA vaccine reactogenicity and durability Open
Introduction Natural killer (NK) cells can both amplify and regulate immune responses to vaccination. Studies in humans and animals have observed NK cell activation within days after mRNA vaccination. In this study, we sought to determine …
View article: CD22 CAR T-cell associated hematologic toxicities, endothelial activation and relationship to neurotoxicity
CD22 CAR T-cell associated hematologic toxicities, endothelial activation and relationship to neurotoxicity Open
Background Hematologic toxicities, including coagulopathy, endothelial activation, and cytopenias, with CD19-targeted chimeric antigen receptor (CAR) T-cell therapies correlate with cytokine release syndrome (CRS) and neurotoxicity severit…
View article: Biomarkers of gut barrier dysfunction and risk of hepatocellular carcinoma in the <scp>REVEAL‐HBV</scp> and <scp>REVEAL‐HCV</scp> cohort studies
Biomarkers of gut barrier dysfunction and risk of hepatocellular carcinoma in the <span>REVEAL‐HBV</span> and <span>REVEAL‐HCV</span> cohort studies Open
Gut barrier dysfunction can result in the liver being exposed to an elevated level of gut‐derived bacterial products via portal circulation. Growing evidence suggests that systemic exposure to these bacterial products promotes liver diseas…
View article: CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR
CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR Open
Remission durability following single-antigen targeted chimeric antigen receptor (CAR) T-cells is limited by antigen modulation, which may be overcome with combinatorial targeting. Building upon our experiences targeting CD19 and CD22 in B…
View article: Phase I Clinical Trial of an Autologous Dendritic Cell Vaccine Against HER2 Shows Safety and Preliminary Clinical Efficacy
Phase I Clinical Trial of an Autologous Dendritic Cell Vaccine Against HER2 Shows Safety and Preliminary Clinical Efficacy Open
Background Despite recent advances, there is an urgent need for agents targeting HER2-expressing cancers other than breast cancer. We report a phase I study (NCT01730118) of a dendritic cell (DC) vaccine targeting HER2 in patients with met…
View article: Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells
Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells Open
Chimeric antigen receptor (CAR) T-cell toxicities resembling hemophagocytic lymphohistiocytosis (HLH) occur in a subset of patients with cytokine release syndrome (CRS). As a variant of conventional CRS, a comprehensive characterization of…
View article: Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses
Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses Open
Influenza hemagglutinin (HA) is considered a major protective antigen of seasonal influenza vaccine but antigenic drift of HA necessitates annual immunizations using new circulating HA versions. Low variation found within conserved non-HA …
View article: Consequences of hemophagocytic lymphohistiocytosis‐like cytokine release syndrome toxicities and concurrent bacteremia
Consequences of hemophagocytic lymphohistiocytosis‐like cytokine release syndrome toxicities and concurrent bacteremia Open
Serious bacterial infections (SBI) can lead to devastating complications with CD19 CAR T cells and cytokine release syndrome (CRS). Little is known about consequences of and risk factors for SBI with novel CAR T‐cell constructs or with CRS…
View article: Evaluation of the AV7909 Anthrax Vaccine Toxicity in Sprague Dawley Rats Following Three Intramuscular Administrations
Evaluation of the AV7909 Anthrax Vaccine Toxicity in Sprague Dawley Rats Following Three Intramuscular Administrations Open
AV7909 is a next-generation anthrax vaccine under development for post-exposure prophylaxis following suspected or confirmed Bacillus anthracis exposure, when administered in conjunction with the recommended antibacterial regimen. AV7909 c…